6-Substituted l-Methylquinolinium-2-dithioacetic Acid Zwitterions: Antileukemia Activity

Carboxylic acid functionalized imidazolium salts: sequential formation of ionic, zwitterionic, acid-zwitterionic and lithium salt-zwitterionic liquid crystals

“…[40][41][42] Furthermore, deprotonation of acid functionalized imidazolium salts produces zwitterionic liquids (ZILs) [43][44][45][46][47] and zwitterionic liquid crystals (ZILCs). [48][49][50][51][52][53][54][55][56] ZILs are electronically neutral but carry formal positive and negative charges in a molecule that has attracted recent research interests, [57][58][59][60][61][62][63][64][65][66][67][68][69][70][71] especially in their application in ion transport. [72][73][74][75] Although the utilization of carboxylic acid and carboxylate functionalized imidazolium salts as taskspecific ILs and ZILs have been studied, 39,44,45,[76][77][78][79][80][81][82][83]…”

Synthesis and Antileukemic Activity of 2-(2-Methylthio-2-aminovinyl)-1-methylquinolinium Iodides

“…The official USP XX procedure for the analytical determination of this drug substance, both alone and in its pharmaceutical dosage form, is based on the reaction of I with excess silver nitrate, producing the silver acetylide and nitric acid (1,2). The official USP XX procedure for the analytical determination of this drug substance, both alone and in its pharmaceutical dosage form, is based on the reaction of I with excess silver nitrate, producing the silver acetylide and nitric acid (1,2).…”

“…A series of 6-substituted-1-methylquinolinium-2-dithioacetic acid zwitterions (I) (1,2) has shown appreciable antileukemic activity against P-388 lymphocytic leukemia in mice. An attempt to find compounds having better solubilities, in both water and organic solvents, led to the synthesis of the derived 2-bis(2-methylthio)vinyl-lmethylquinolinium iodides (11) (3).…”