60 Fluticasone propionate treatment for seasonal allergic rhinitis is safe and effective in adults and adolescents

LaForce, Craig; Dockhorn, Robert J.; Findlay, Steven R.; Meltzer, E.O.; Nathan, Robert A.; Stricker, William E.; Weakley, S; Beam, Joel W.; Rogenes, Paula R.

doi:10.1016/0091-6749(91)91343-r

Cited by 20 publications

(18 citation statements)

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“…For children between the ages of 4-11 years, half the dose is recommended. Side effects are similar to those of the other inhaled corticosteroids described above (LaForce et al, 1994).…”

Section: Fluticasone Propionatesupporting

confidence: 64%

Treatment of Allergic Rhinitis: Anticholinergics, Glucocorticotherapy, Leukotriene Antagonists, Omalizumab and Specific-Allergen Immunotherapy

Palomo¹,

Bobolea²,

Gonzalez³

et al. 2012

Otolaryngology

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“…For children between the ages of 4-11 years, half the dose is recommended. Side effects are similar to those of the other inhaled corticosteroids described above (LaForce et al, 1994).…”

Section: Fluticasone Propionatesupporting

confidence: 64%

Treatment of Allergic Rhinitis: Anticholinergics, Glucocorticotherapy, Leukotriene Antagonists, Omalizumab and Specific-Allergen Immunotherapy

Palomo¹,

Bobolea²,

Gonzalez³

et al. 2012

Otolaryngology

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“…MFNS was associated with a significant reduction in total nasal symptom scores (standardized mean difference (SMD), −0.49; 95% confidence interval (CI), −0.60 to −0.38; P<0.00001), total nonnasal symptom scores (−0.30; 95% CI, −0.43 to −0.18; P<0.00001), and rhinorrhea (SMD, −0.44; 95% CI, −0.66 to −0.21; P=0.0001), as well as the other individual nasal symptoms evaluated [46]. Specifically with regard to rhinorrhea, a number of individual clinical trials, as well as several meta-analyses, support the efficacy of INS for relief of this particularly bothersome AR symptom (Table 4) [46][47][48][49][50][51][52][53][54][55][56][57][58][59][60][61][62].…”

Section: Clinical Efficacy Of Ins For Rhinorrhea In Armentioning

confidence: 79%

“…This reduction was apparent within 36 h of treatment initiation and was maintained for the duration of treatment [54].…”

Section: Seasonal Allergic Rhinitismentioning

confidence: 83%

Intranasal Steroids in the Treatment of Allergy-Induced Rhinorrhea

Nathan¹

2010

Clinic Rev Allerg Immunol

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While nasal congestion has been identified as one of the most bothersome and prevalent symptoms of allergic rhinitis, it is underappreciated that many patients find rhinorrhea also to be bothersome. Rhinorrhea as a symptom of allergic rhinitis virtually never occurs alone; about 97% of patients with allergic rhinitis suffer from at least two symptoms, a finding that underscores the advantage of treating a broad range of symptoms with a single medication. Along with sneezing and nasal obstruction, rhinorrhea is a classic acute symptom of allergic rhinitis; it appears as a late-phase symptom as well. In this review, the characterization and epidemiology of rhinorrhea, the pathophysiology of rhinorrhea in allergic rhinitis, the roles played by mediators in early- and late-phase rhinorrhea, the prevalence and impact of this symptom, and the efficacy and safety of available treatment options are all discussed in context of relevant literature. A review of the clinical studies assessing the efficacy of intranasal corticosteroids (INS) for rhinorrhea is presented. Many clinical studies and several meta-analyses conclusively demonstrate that, in addition to being safe and well-tolerated, INS are more effective than other agents (including oral and intranasal antihistamines) across the spectrum of AR symptoms, including rhinorrhea and nasal congestion.

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“…The antirhinitis effect of f1uticasone 200~g once daily and beclomethasone l68~g twice daily were equal in 2 studies, [66,67] while another 2 large multicentre studies showed a better effect of f1uticasone 200~g twice daily than of beclomethasone l68~g [68] …”

Section: Efficacymentioning

confidence: 98%