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Inclusion of molybdenocene dichloride (Cp2MoCl2) in 2-hydroxypropyl- and trimethyl-β-cyclodextrin: Structural and biological properties

“…Raman spectra were recorded on a Bruker RFS 100/S FT-Raman system, using a Nd:YAG laser, 1064 nm excitation (50 mW at the sample position) and a InGaAs detector. Room-temperature solid-state 13 m = 3586m, 3519m, 3099m, 2979s, 2930s, 2895sh, 2831s, 2072w, 1641w, 1460m, 1403w, 1366m, 1321m, 1304m, 1256sh, 1230m, 1195m, 1162vs, 1143vs, 1108vs, 1089vs, 1065vs, 1038vs, 1021sh, 970s, 952m, 910m, 856m, 831m, 808sh, 755m, 705m, 668w, 600sh, 558m, 468w. Raman (cm À1 ): 3124m, 3119m, 3102m, 2977s, 2929s, 2894s, 2829s, 1449m, 1118s, 1061w, 974w, 417w, 414w, 343m, 328vs, 290m, 260w, 211w, 194m, 170sh, 163m, 154m, 129w, 84m.…”

“…Raman (cm À1 ): 3124m, 3119m, 3102m, 2977s, 2929s, 2894s, 2829s, 1449m, 1118s, 1061w, 974w, 417w, 414w, 343m, 328vs, 290m, 260w, 211w, 194m, 170sh, 163m, 154m, 129w, 84m. 13 : m = 3379vs, 3118sh, 2968m, 2928s, 2887sh, 1648m, 1460m, 1423m, 1370m, 1335m, 1300m, 1244m, 1156vs, 1123sh, 1082vs, 1033vs, 947s, 850sh, 840m, 818sh, 757m, 705m, 610m, 581m. Raman (cm À1 ): 3367m, 3122s, 2930vs, 2901vs, 1454s, 1382m, 1326s, 1248m, 1117vs, 1079s, 940m, 931m, 839m, 590w, 475w, 411w, 405w, 346sh, 341s, 325vs, 290m, 259w, 206w, 194m, 161m, 154m, 84vs.…”

“…Raman (cm À1 ): 3367m, 3122s, 2930vs, 2901vs, 1454s, 1382m, 1326s, 1248m, 1117vs, 1079s, 940m, 931m, 839m, 590w, 475w, 411w, 405w, 346sh, 341s, 325vs, 290m, 259w, 206w, 194m, 161m, 154m, 84vs. 13 …”

“…Recently, b-cyclodextrin (b-CD) encapsulation of Cp 2 TiCl 2 [13] and Cp 2 MoCl 2 [14] was described. CD inclusion compounds are interesting for pharmaceutical use owing to the enhanced solubility, stability and bioavailability of the drug molecules [15,16].…”

22 Ti Anti‐Tumor Titanium Drugs

“…55 Complex formation between -cyclodextrin and Cp 2 Ti IV Cl 2 has been proven in solution. 67 The encapsulation of Cp 2 Ti IV Cl 2 in -cyclodextrin yields inclusion complexes interesting for pharmaceutical use, owing to the increased aqueous solubility of the drug, better oral absorption, and enhanced chemical and physical stability with respect to oxidation by air, sensitivity to light, rate of disproportionation or polymerization and acidic conditions. 51 An interesting new approach involving heterobimetallic complexes containing platinum linked to titanium by an organic ligand with hard and soft donors has recently been published.…”