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Сухих, Г. Т.; Malaitsev, V. V.; Bogdanova, I. M.; Dubrovina, I. V.

doi:10.1023/a:1015560831444

Cited by 26 publications

(10 citation statements)

References 45 publications

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“…The ability to leave the tissue niche, circulate in the bloodflow and, getting into certain environment, to differentiate in the appropriate direction is the most important functional characteristics of stem cells [1,10]. Methods of pharmacological mobilization of hemopoietic precursors (stimulation of their release into the blood from depot) are described [15,17].…”

Section: Smentioning

confidence: 99%

Creation of experimental models and study of the regeneratory potential of stem cells on these models

Gol'dberg¹,

Дыгай²,

Жданов³

et al. 2007

Bull Exp Biol Med

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Mobilization of mesenchymal stem cells and their more mature descendants, their differentiation into tissue-specific precursors, and the possibility of pharmacological stimulation of these processes were studied on models of some prevalent diseases. It was found that the development of any pathological process was associated with more or less pronounced activation of primitive and more differentiated mesenchymal precursors in the bone marrow, their mobilization into the peripheral blood, and increase in the content of regional precursors in organs exposed to pathogenic factors. Additional stimulation of stem cells with granulocytic colony-stimulating factor usually led to earlier or more pronounced increase in the content of mesenchymal progenitors in the bone marrow and peripheral blood. The content of tissue-specific and then fibroblast precursors in the regenerating organs also increased. This was paralleled by a decrease in the volume of developing connective tissue and degree of infiltration in these organs, while the percentage of tissue-specific structures increased.

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Section: Smentioning

confidence: 99%

Creation of experimental models and study of the regeneratory potential of stem cells on these models

Gol'dberg¹,

Дыгай²,

Жданов³

et al. 2007

Bull Exp Biol Med

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show abstract

“…Mesenchymal SC are spindleshaped cells with irregular processes demonstrating positive reaction for CD13 + , CD29 + , CD44 + , and CD71 + markers and negative reaction for CD3 -, CD14 -, CD15 -, CD33 -, CD34 -, CD38 -, CD45 -, and HLA-DR markers [26,117]. These cells differ from hemopoietic SC by CD34 -marker.…”

Section: Stem Cells -Facultative or Obligate Proliferative Reserve Ofmentioning

confidence: 99%

Whether Modern Cell Technologies Can Break Down Biological Limitations of Tissue-Specific Regeneration of the Myocardium

2005

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The paper reviews modern concepts of physiological and reparative regeneration of the myocardium as a highly specific and highly differentiated tissue system. Special attention was given to evaluation of the proliferative potential of cardiomyocytes, in particular, to the existence of a population of resident cardiac stem cells in the myocardium. Modern approaches to replenishment of massive cardiomyocyte loss via transplantation and transdifferentiation of adult and embryonic stem cells are discussed and the possibilities of using cell technologies for induction of tissue-specific regeneration of the myocardium are analyzed.

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“…These are mainly the so-called "regional stem cells", retained in organs during the postnatal period and ensuring physiological and reparative regeneration. During alteration they migrate to the zone of injury, divide and maturate, forming the appropriate tissue cells; that is, due to these cells the tissues are restored by restitution [5,8]. Though under common conditions and in vitro the regional precursors develop only into cells of the organ from which they were isolated, many scientists consider them multipotent.…”

mentioning

confidence: 99%

“…Regional stem cells of muscles, epidermis, intestinal epithelium, liver, etc. are also multipotent [2,5,12].…”

mentioning

confidence: 99%

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Modern Views on the Problem of Stem Cells and Potentialities of Their Use in Medicine

2005

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Untitled

Cited by 26 publications

References 45 publications

Creation of experimental models and study of the regeneratory potential of stem cells on these models

Creation of experimental models and study of the regeneratory potential of stem cells on these models

Whether Modern Cell Technologies Can Break Down Biological Limitations of Tissue-Specific Regeneration of the Myocardium

Modern Views on the Problem of Stem Cells and Potentialities of Their Use in Medicine

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