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Rosolen, Serge G.; Rigaudière, Florence; Saint-Macary, Gérard; Lachapelle, Pierre

doi:10.1023/a:1002445219981

Cited by 12 publications

(2 citation statements)

References 9 publications

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“…Previous studies of ERG using normal pig showed the a-wave implicit time (16.6 ms) in rod-cone response, b-wave implicit time (41.8–47.4 ms) in rod-cone response, a-wave implicit time (12.7–16.7 ms) in maximal rod-cone response, b-wave implicit time (36.0–45.0 ms) in maximal rod-cone response, a-wave implicit time (8.37–13.4 ms) in cone response, and b-wave implicit time (29.6–33.5 ms) in cone response. 33 , 34 , 59 , 60 The b-wave amplitude of 10.0 ERG in our study showed a smaller amplitude than that of 3.0 ERG.…”

Section: Discussioncontrasting

confidence: 58%

Normative Data of Axial Length, Retinal Thickness Measurements, Visual Evoked Potentials, and Full-Field Electroretinography in Female, Wild-Type Minipigs

Choi

Anh

et al. 2021

Trans. Vis. Sci. Tech.

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Purpose The purpose of this study was to present normative data of optical coherence tomography (OCT), electrophysiological, and ocular biometry parameters and their correlation in minipigs. Methods Eighty-eight eyes of 44 minipigs underwent full-field electroretinogram (ERG) recording and ocular biometry. However, 10 eyes of 6 minipigs were excluded because of poor OCT image quality. The thickness of the retinal sublayers was measured on a vertical line at 5 locations with a 1 mm interval from the disc margin to the dorsal periphery and at 10 locations on the visual streak. Visual evoked potentials (VEPs) were measured in 15 eyes of 8 minipigs. Results All minipigs were female with a mean age and axial length of 13.83 ± 10.56 months and 20.33 ± 0.88 mm, respectively. The implicit time of the a-wave and b-wave in scotopic 3.0 ERGs was longer than that in photopic 3.0 ERG. The implicit time of the n2-wave and p2-wave in VEP was 25.67 ± 7.41 ms and 52.96 ± 10.38 ms, respectively. The total retinal layer (TRL) and nerve fiber layer (NFL) became thinner near the periphery. The inner retinal sublayers near the visual streak were thicker than those at other locations. Central TRL and NFL thickness on visual streak was 223.06 ± 23.19 µm and 74.03 ± 13.93 µm, respectively. The temporal TRL and NFL on the visual streak were thicker than those on the nasal side. Conclusions The normative electrophysiological and OCT parameters used in our study can be used as reference data in further pig studies. Translational Relevance This study presents normative data of minipigs, which are adequate animal models for preclinical studies.

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Section: Discussioncontrasting

confidence: 58%

Normative Data of Axial Length, Retinal Thickness Measurements, Visual Evoked Potentials, and Full-Field Electroretinography in Female, Wild-Type Minipigs

Choi

Anh

et al. 2021

Trans. Vis. Sci. Tech.

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“…Previous studies also exist regarding ERG recordings from conscious animals such as yucatan micropigs [26], rats [32], and dogs [28]. The studies revealed that recording artifacts from blinks, eye, and head movements are frequent in the conscious dogs, which necessitate the averaging of the multiple responses in order to reduce the artifcact effect [17].…”

Section: Introductionmentioning

confidence: 99%

The determination of dark adaptation time using electroretinography in conscious Miniature Schnauzer dogs

Jeong

Park

et al. 2007

J Vet Sci

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The optimal dark adaptation time of electroretinograms (ERG's) performed on conscious dogs were determined using a commercially available ERG unit with a contact lens electrode and a built-in light source (LED-electrode). The ERG recordings were performed on nine healthy Miniature Schnauzer dogs. The bilateral ERG's at seven different dark adaptation times at an intensity of 2.5 cd·s/m2 was performed. Signal averaging (4 flashes of light stimuli) was adopted to reduce electrophysiologic noise. As the dark adaptation time increased, a significant increase in the mean a-wave amplitudes was observed in comparison to base-line levels up to 10 min (p < 0.05). Thereafter, no significant differences in amplitude occured over the dark adaptation time. Moreover, at this time the mean amplitude was 60.30 ± 18.47 µV. However, no significant changes were observed for the implicit times of the a-wave. The implicit times and amplitude of the b-wave increased significantly up to 20 min of dark adaptation (p < 0.05). Beyond this time, the mean b-wave amplitudes was 132.92 ± 17.79 µV. The results of the present study demonstrate that, the optimal dark adaptation time when performing ERG's, should be at least 20 min in conscious Miniature Schnauzer dogs.

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Steady-state electroretinograms and pattern electroretinograms in pigs

Janknecht¹,

Wesendahl²,

Feltgen³

et al. 2001

Graefe's Arch Clin Exp Ophthalmol

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It was possible to record ERGs and PERGs in pigs. However, the ERG amplitudes were small; PERG amplitudes were even smaller in both groups and cannot be reliably recorded. A problem for both ERG and PERG was the high intra-individual and interindividual variability. Therefore, only very extensive damage to the retina by vitrectomy or Er:YAG laser treatment might lead to a significant change in the ERG or PERG amplitudes.

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Cited by 12 publications

References 9 publications

Normative Data of Axial Length, Retinal Thickness Measurements, Visual Evoked Potentials, and Full-Field Electroretinography in Female, Wild-Type Minipigs

Normative Data of Axial Length, Retinal Thickness Measurements, Visual Evoked Potentials, and Full-Field Electroretinography in Female, Wild-Type Minipigs

The determination of dark adaptation time using electroretinography in conscious Miniature Schnauzer dogs

Steady-state electroretinograms and pattern electroretinograms in pigs

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