631 Transurethral water vapor therapy for BPH; initial clinical results of the first in man trial and Rezm™ I pilot study

Dixon, Crawford; Rijo, Cedano E.; Pacík, Dalibor; Vit, V.; Varga, Gabriel; Mynderse, Lance A.; Hanson, D.; Larson, Timothy S.

doi:10.1016/s1569-9056(13)61114-8

Cited by 2 publications

(2 citation statements)

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“…This thermal energy denatures the cell membranes immediately, causing instantaneous cell death. The first-in-man trial was a dose-ranging study 35 in which the energy delivered ranged from 190 to 289 calories per injection. In the Rezum I pilot study, all patients received the same dose of 208 calories per injection.…”

Section: Devices For Delivery Of Thermal Treatmentmentioning

confidence: 99%

Minimally invasive devices for treating lower urinary tract symptoms in benign prostate hyperplasia: technology update

Aoun

Marcelis

Roumeguère

2015

RRU

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Benign prostatic hyperplasia (BPH) represents a spectrum of related lower urinary tract symptoms (LUTS). The cost of currently recommended medications and the discontinuation rate due to side effects are significant drawbacks limiting their long-term use in clinical practice. Interventional procedures, considered as the definitive treatment for BPH, carry a significant risk of treatment-related complications in frail patients. These issues have contributed to the emergence of new approaches as alternative options to standard therapies. This paper reviews the recent literature regarding the experimental treatments under investigation and presents the currently available experimental devices and techniques used under local anesthesia for the treatment of LUTS/BPH in the vast majority of cases. Devices for delivery of thermal treatment (microwaves, radiofrequency, high-intensity focused ultrasound, and the Rezum system), mechanical devices (prostatic stent and urethral lift), fractionation of prostatic tissue (histotripsy and aquablation), prostate artery embolization, and intraprostatic drugs are discussed. Evidence for the safety, tolerability, and efficacy of these “minimally invasive procedures” is analyzed.

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Section: Devices For Delivery Of Thermal Treatmentmentioning

confidence: 99%

Minimally invasive devices for treating lower urinary tract symptoms in benign prostate hyperplasia: technology update

Aoun

Marcelis

Roumeguère

2015

RRU

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“…The Rezum System was reported to achieve effective, rapid, controlled, prostatic ablation with a procedure time of less than 5 min, clinically relevant improvements in IPSS, QoL, Qmax, and PVR at 6 months, and without reports of urinary incontinence, erectile dysfunction, or ejaculatory dysfunction as a consequence of treatment [20]. Combined results of a 15 patient first-in-man dose-ranging trial and a 15 patient Rezum I (pilot) study were presented at the 2013 European Association of Urology Congress.…”

Section: Rezummentioning

confidence: 99%

What's truly minimally invasive in benign prostatic hyperplasia surgery?

Chung

Woo²

2014

Current Opinion in Urology

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Urolift appears to be a well tolerated and effective minimally invasive treatment for lower urinary tract symptoms due to BPH in men who wish to preserve sexual function or who are not suitable for invasive surgery. Further studies will confirm the currently mixed results regarding intraprostatic botulinum toxin or ethanol injections. Rezum, Histotripsy, and Aquablation are experimental treatments under investigation.

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631 Transurethral water vapor therapy for BPH; initial clinical results of the first in man trial and Rezm™ I pilot study

Cited by 2 publications

References 0 publications

Minimally invasive devices for treating lower urinary tract symptoms in benign prostate hyperplasia: technology update

Minimally invasive devices for treating lower urinary tract symptoms in benign prostate hyperplasia: technology update

What's truly minimally invasive in benign prostatic hyperplasia surgery?

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