634 Angiotensin II Regulates the Expression of Monocyte Chemoattractant Protein- 1 in Pancreatic Cancer Cells

Chehl, Navdeep; Chipitsyna, Galina; Gong, Qiaoke; Yeo, Charles J.; Arafat, Hwyda A.

doi:10.1016/s0016-5085(09)64048-8

Cited by 4 publications

(4 citation statements)

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“…In addition, Nigella sativa had beneficial properties in some cases of nephrotoxicity based on biochemical renal function parameters (Dollah et al, 2013;Mousavi, 2015). tokines against viral pathogens (Ahmad et al, 2013), inhibitory effect on cytokine production or activation (Boskabady et al, 2011;Keyhanmanesh et al, 2010;Salem, 2005;Terzi et al, 2010), combines pro-apoptotic and inflammatory mechanisms of action (Chehl et al 2009) and mainly works by suppressing type 2 cytokines and secreting mucus from the airways (Azimi et al, 2016). Nigella sativa oil has an immune response to A. hydrophila in A. testudineus (Khatun et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Therapeutic effect of Nigella sativa oil and ciprofloxacin against bacterial infection based on interleukin 1β expression and kidney histopathological alterations in Oreochromis niloticus

Hal

El‐Barbary

2021

Aquaculture Research

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The study evaluated the effect of Nigella sativa oil (NSO) and ciprofloxacin (CFX) on Oreochromis niloticus infected with Aeromonas hydrophila and Pseudomonas fluorescens through kidney function, histopathological changes of kidney and relative expression of interleukin 1β (IL‐1β) in fish organs. The studied fish were divided into four groups based on supplemented diets; each group was divided into three subgroups based on the type of the infection. The results showed increased levels of urea in all infected A. hydrophila and P. fluorescens groups while serum creatinine levels decreased in treated infected subgroups compared to controls. NSO and CFX treatments led to less histological damages in the kidney of infected groups despite the derangement of serum urea and creatinine levels. The up‐regulation of IL‐1β expression was varied based on the type of bacterial infection. After the bacterial infection, NSO led to down‐regulation of IL‐1β expression except in the kidney and gill in P. fluorescens infected subgroups while CFX led to up‐regulation of IL‐1β expression in most studied organs. A positive correlation was observed between serum urea levels and IL‐1β expression levels in the kidney, gill and liver while a negative correlation was observed between serum creatinine values and IL‐1β expression levels in the kidney and muscle. All the studied treatment modalities are effective in augmenting immune response and control of infections.

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Section: Discussionmentioning

confidence: 99%

Therapeutic effect of Nigella sativa oil and ciprofloxacin against bacterial infection based on interleukin 1β expression and kidney histopathological alterations in Oreochromis niloticus

Hal

El‐Barbary

2021

Aquaculture Research

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“…TQ can be utilised as an anti-proliferative, pro-apoptotic, anti-angiogenic, and anti-angiogenic agent, as well as a cell cycle arrest inducer, according to the molecular signals (Majdalawieh and Fayyad, 2016;ElKhoely et al, 2015). TQ induced apoptosis and inhibited growth in pancreatic cancer cells, according to previous research (Chehl et al, 2009). Others looked at whether TQ had an inhibitory effect on malignant cell growth in a variety of cell types (Chen et al, 2012).…”

Section: Research Articlementioning

confidence: 99%

Thymoquinone Crosstalks with DR5 to Sensitize TRAIL Resistance and Stimulate ROS-Mediated Cancer Apoptosis

Abdrabou

El-Salam²,

Sharada

et al. 2021

Asian Pac J Cancer Prev

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Human breast cancer MCF-7 and MDA-MB-231 cell lines provide suitable models for in vitro treatment of breast cancer. Ovarian estrogens are required for the onset and progression of human breast cancer. The MCF-7 breast cancer cell line possesses efficient oestrogen receptors (ER), but the MDA-MB-231 human breast cancer cell line lacks ER and is unresponsive to ER and anti-ER (Ren et al., 2018).There are numerous community therapies for various malignancies that prevent cancer proliferation by

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“…In Africa and Asia, these seeds were also used as a folk medicine to treat some diseases (Sutton et al, 2014). Thymoquinone (TQ, 2-methyl-5-isopropyl-1,4-benzoquinone), one of the functional constituents of the essential oil of Nigella sativa seeds, exhibits various pharmaceutical activities including anti-tumor, anti-inflammatory, anti-allergic, antidiabetic, antimicrobial, and hepatoprotective effects (Chehl et al, 2009;Aziz et al, 2011;Forouzanfar et al, 2014;Abdelrazek et al, 2018;Noorbakhsh et al, 2018;Yang et al, 2015). In addition, TQ was reported to be able to inhibit biofilm formation by some pathogenic bacteria including Cronobacter sakazakii (Shi et al, 2017), Pseudomonas aeruginosa (Chakraborty et al, 2021), Vibrio parahaemolyticus (Guo et al, 2019), and Listeria monocytogenes (Liu et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Inactivation Effect of Thymoquinone on Alicyclobacillus acidoterrestris Vegetative Cells, Spores, and Biofilms

et al. 2021

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Alicyclobacillus acidoterrestris (A. acidoterrestris), a spore-forming bacterium, has become a main challenge and concern for the juices and acid beverage industry across the world due to its thermo-acidophilic characteristic. Thymoquinone (TQ) is one of the active components derived from Nigella sativa seeds. The objective of this study was to investigate antibacterial activity and associated molecular mechanism of TQ against A. acidoterrestris vegetative cells, and to evaluate effects of TQ on A. acidoterrestris spores and biofilms formed on polystyrene and stainless steel surfaces. Minimum inhibitory concentrations of TQ against five tested A. acidoterrestris strains ranged from 32 to 64 μg/mL. TQ could destroy bacterial cell morphology and membrane integrity in a concentration-dependent manner. Field-emission scanning electron microscopy observation showed that TQ caused abnormal morphology of spores and thus exerted a killing effect on spores. Moreover, TQ was effective in inactivating and removing A. acidoterrestris mature biofilms. These findings indicated that TQ is promising as a new alternative to control A. acidoterrestris and thereby reduce associated contamination and deterioration in the juice and acid beverage industry.

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634 Angiotensin II Regulates the Expression of Monocyte Chemoattractant Protein- 1 in Pancreatic Cancer Cells

Cited by 4 publications

References 0 publications

Therapeutic effect of Nigella sativa oil and ciprofloxacin against bacterial infection based on interleukin 1β expression and kidney histopathological alterations in Oreochromis niloticus

Therapeutic effect of Nigella sativa oil and ciprofloxacin against bacterial infection based on interleukin 1β expression and kidney histopathological alterations in Oreochromis niloticus

Thymoquinone Crosstalks with DR5 to Sensitize TRAIL Resistance and Stimulate ROS-Mediated Cancer Apoptosis

Inactivation Effect of Thymoquinone on Alicyclobacillus acidoterrestris Vegetative Cells, Spores, and Biofilms

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