68Ga–Prostate-Specific Membrane Antigen PET–Positive Paget Bone Disease With Metastatic Prostatic Carcinoma

Engur, Ceren Ozge; Turoğlu, Halil Turgut; Özgüven, Salih; Tanıdır, Yılören; Erdıl, Tanju Yusuf

doi:10.1097/rlu.0000000000003198

Cited by 7 publications

(9 citation statements)

References 12 publications

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“…Bone is one of the most common sites of recurrence in prostate cancer 1 . 68 Ga-PSMA uptake by benign bone entities, including healing fractures, osteoarthritis, fibrous dysplasia, and Paget disease, has been documented, posing a diagnostic dilemma on 68 Ga-PSMA PET/CT and creating the potential for false-positive results 2–8 . The intense uptake in our patient’s SI joints is unusual as the intensity of PSMA uptake tends to be higher in malignant bone lesions than in benign pathologies, which usually demonstrate mild to moderate activity 9 .…”

mentioning

confidence: 74%

Spurious Uptake on 68Ga–Prostate-Specific Membrane Antigen PET/CT Due to Ankylosing Spondylitis; A Rare Pitfall in Imaging of Biochemical Recurrence of Prostate Cancer

2021

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Bone is one of the most common sites of prostate cancer recurrence, and 68Ga–prostate-specific membrane antigen (PSMA) uptake by benign bone entities poses a diagnostic dilemma. We describe the case of a 60-year-old man with recurrence in a small presacral node on 68Ga-PSMA PET/CT. Of note, the images also demonstrated bilateral asymmetrical sacroiliac joint uptake. A history of ankylosing spondylitis was subsequently elicited, confirming the radiographic suspicion of sacroiliitis, therefore confirming the nonmalignant nature of 68Ga-PSMA uptake related to sacroiliitis rather than osseous recurrence from prostate carcinoma. 68Ga-PSMA uptake may indicate angioneogenesis in sacroiliitis and consequently may be helpful in assessing disease activity and therapy response.

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confidence: 74%

Spurious Uptake on 68Ga–Prostate-Specific Membrane Antigen PET/CT Due to Ankylosing Spondylitis; A Rare Pitfall in Imaging of Biochemical Recurrence of Prostate Cancer

2021

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“…9,39 Additionally, ex vivo images of tumors and healthy organs harvested from mice 8 h post injection showed that 4WJ-X-EGFR apt nanoparticles strongly accumulated in tumors, with low or no accumulation in the liver or other organs. 5 Prostate-specific membrane antigen (PSMA) was detected in prostate cancer cells and the neovasculature of different kinds of malignant neoplasms, including breast, 429 brain, 430,431 lung, 430 and other cancers 432 but not in normal vascular endothelium. Our previous study demonstrated ligand− receptor binding of RNA nanoparticles with PSMA aptamers (Figure 30C) and PSMA-RNA nanoparticle displaying EVs.…”

Section: Rna Nanoparticles Functionalized With Targeting Groups As Ac...mentioning

confidence: 99%

“…Prostate-specific membrane antigen (PSMA) was detected in prostate cancer cells and the neovasculature of different kinds of malignant neoplasms, including breast, brain, , lung, and other cancers but not in normal vascular endothelium. Our previous study demonstrated ligand–receptor binding of RNA nanoparticles with PSMA aptamers (Figure C) and PSMA-RNA nanoparticle displaying EVs.…”

Section: Active Delivery Of Therapeutics By Rna Nanoparticles To Dise...mentioning

confidence: 99%

Thermostability, Tunability, and Tenacity of RNA as Rubbery Anionic Polymeric Materials in Nanotechnology and Nanomedicine—Specific Cancer Targeting with Undetectable Toxicity

Binzel

Burns

et al. 2021

Chem. Rev.

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RNA nanotechnology is the bottom-up self-assembly of nanometer-scale architectures, resembling LEGOs, composed mainly of RNA. The ideal building material should be (1) versatile and controllable in shape and stoichiometry, (2) spontaneously self-assemble, and (3) thermodynamically, chemically, and enzymatically stable with a long shelf life. RNA building blocks exhibit each of the above. RNA is a polynucleic acid, making it a polymer, and its negative-charge prevents nonspecific binding to negatively charged cell membranes. The thermostability makes it suitable for logic gates, resistive memory, sensor set-ups, and NEM devices. RNA can be designed and manipulated with a level of simplicity of DNA while displaying versatile structure and enzyme activity of proteins. RNA can fold into single-stranded loops or bulges to serve as mounting dovetails for intermolecular or domain interactions without external linking dowels. RNA nanoparticles display rubber- and amoeba-like properties and are stretchable and shrinkable through multiple repeats, leading to enhanced tumor targeting and fast renal excretion to reduce toxicities. It was predicted in 2014 that RNA would be the third milestone in pharmaceutical drug development. The recent approval of several RNA drugs and COVID-19 mRNA vaccines by FDA suggests that this milestone is being realized. Here, we review the unique properties of RNA nanotechnology, summarize its recent advancements, describe its distinct attributes inside or outside the body and discuss potential applications in nanotechnology, medicine, and material science.

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“…The prostate-specific antigen (PSA) was spotted in prostate cancer cells and the neovasculature of many types of malicious neoplasms, such as breast cancer [88], lung [89], and some other tumor cells [90]. One study reported ligand-receptor relation of RNA NPs with PSA aptamers.…”

Section: Prostate Cancermentioning

confidence: 99%

Novel Perspectives towards RNA-Based Nano-Theranostic Approaches for Cancer Management

et al. 2021

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In the fight against cancer, early diagnosis is critical for effective treatment. Traditional cancer diagnostic technologies, on the other hand, have limitations that make early detection difficult. Therefore, multi-functionalized nanoparticles (NPs) and nano-biosensors have revolutionized the era of cancer diagnosis and treatment for targeted action via attaching specified and biocompatible ligands to target the tissues, which are highly over-expressed in certain types of cancers. Advancements in multi-functionalized NPs can be achieved via modifying molecular genetics to develop personalized and targeted treatments based on RNA interference. Modification in RNA therapies utilized small RNA subunits in the form of small interfering RNAs (siRNA) for overexpressing the specific genes of, most commonly, breast, colon, gastric, cervical, and hepatocellular cancer. RNA-conjugated nanomaterials appear to be the gold standard for preventing various malignant tumors through focused diagnosis and delivering to a specific tissue, resulting in cancer cells going into programmed death. The latest advances in RNA nanotechnology applications for cancer diagnosis and treatment are summarized in this review.

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68Ga–Prostate-Specific Membrane Antigen PET–Positive Paget Bone Disease With Metastatic Prostatic Carcinoma

Cited by 7 publications

References 12 publications

Spurious Uptake on 68Ga–Prostate-Specific Membrane Antigen PET/CT Due to Ankylosing Spondylitis; A Rare Pitfall in Imaging of Biochemical Recurrence of Prostate Cancer

Spurious Uptake on 68Ga–Prostate-Specific Membrane Antigen PET/CT Due to Ankylosing Spondylitis; A Rare Pitfall in Imaging of Biochemical Recurrence of Prostate Cancer

Thermostability, Tunability, and Tenacity of RNA as Rubbery Anionic Polymeric Materials in Nanotechnology and Nanomedicine—Specific Cancer Targeting with Undetectable Toxicity

Novel Perspectives towards RNA-Based Nano-Theranostic Approaches for Cancer Management

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