7-Keto-8-Aminopelagonic Acid Synthase as a Potential Herbicide Target

Hwang, In Taek; Dong-Hee, Lee; Park, No‐Joong

doi:10.5772/13438

Cited by 3 publications

(1 citation statement)

References 61 publications

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“…However, discovering a chemical structure that could enter the pest, be transported within it, inhibit a key target, get away from detoxification, and also be modified to allow it to fulfill increasing regulatory criteria with respect to environmental compatibility has been required. The structure-based approach uses only appropriate target proteins instead of the entire plant for in vivo testing [2]. In order to perform a structurebased assay, it is necessary to determine a potent target and to have a thorough understanding of the mechanism of action of the target.…”

Section: Introductionmentioning

confidence: 99%

Binding Mode Identification for 7-keto-8-Aminopelargonic Acid Synthase (AtKAPAS) Inhibitors

Kang¹,

Choi²,

Hwang³

2015

Herbicides, Physiology of Action, and Safety

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In this study, we determined the D structure of Arabidopsis thaliana KAPAS by homology modeling. We then investigated the binding mode of compounds obtained from the in-house library using computational docking methods. From the flexible docking study, we achieved high dock scores for the active compounds denoted in this study as compound and compound . Thus, we highlight the flexibility of specific residues, Lys and Phe , when used in active sites.

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Section: Introductionmentioning

confidence: 99%