70-year legacy of the Framingham Heart Study

Andersson, Charlotte; Johnson, Andrew D.; Benjamin, Emelia J.; Levy, Daniel; Vasan, Ramachandran S.

doi:10.1038/s41569-019-0202-5

Cited by 205 publications

(134 citation statements)

References 197 publications

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“…However, except for renal artery stenosis, there were statistically significant differences in the distribution of risk factors compared between groups(P < 0.01). These results are consistent with those of the Framingham Heart Study [16,17]. The result of Framingham Heart Study showed the relative risk of coronary heart disease in obese women increased by 64% and was statistically significant differences compared with a 46% increase in men.…”

Section: Discussionsupporting

confidence: 90%

“…(16) It was recorded as renal artery stenosis that the patients with high blood pressure and with one or bilateral renal artery blood vessel diameter sten-osis≥50% by renal artery color ultrasound or by CT renal artery vascular imaging or by invasive renal artery angiography or by undergoing renal artery stent implantation. (17) It was recorded as hypothyroidism that patient suffered from hypothyroidism and was taking thyroid hormone therapy or plasma thyroxine level was lower than the normal level, and thyrotrophin was elevated at the same time. (18) It was recorded as an autoimmune disease that patient suffered from autoimmune disease in the past week and was taking related drugs treatment.…”

Section: The Judging Criteria For Risk Factorsmentioning

confidence: 99%

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The characteristics of risk factors in Chinese young women with acute coronary syndrome

Liu

Zhou

et al. 2020

BMC Cardiovasc Disord

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Background In recent years, the prevalence rate of acute coronary syndrome (ACS) in Chinese young women has been increasing significantly, becoming one of the main causes of death in young females. A matter of constant concern is what is the characteristics and differences in risk factors between young women with ACS and without ACS. This study aimed to investigate the characteristics and difference of risk factors in Chinese young women with ACS and to provide references for ACS prevention and treatment. Methods A 1:1 case-control study was conducted to evaluate risk factors of 415 young females with ACS (ACS group) who underwent PCI treatment and 415 young females without ACS (control group) who were hospitalized and confirmed by coronary angiography to exclude coronary heart disease from January 2010 to August 2016. The average age of the cases in groups was respectively (40.77 ± 4.02) and (40.57 ± 4.01) years-old (P > 0.05). Results The risk factors in ACS group were overweight (64.10%), hypertension (49.88%), hyperlipidemia (40.72%), diabetes (23.37%), depression or anxiety (16.63%), gynecological diseases (16.39%), Hyperuricemia (14.94%), family history of early-onset CHD (14.94%), hyperhomocysteinemia (11.33%), hypothyroidism (9.64%), hypercholesterolemia (8.43%) and high C-reactive protein (7.47%), and were significant difference (P < 0.01) compared with that of the control group. The average number of risk factors per case in ACS group was significantly more than that of control groups (P < 0.01). Regression analysis showed that hyperlipidemia, hyperhomocysteinemia, overweight (obesity), high CRP, hypertension, hypothyroidism, gynecological diseases, depression or anxiety, cardiac insufficiency, hypercholesterolemia, diabetes, oral contraceptives, family history of early-onset CHD, and autoimmune diseases were independent risk factors (P < 0.01). The bivariate correlation analysis between CRP level and age was r = − 0.158 (P < 0.01). The result showed the younger ACS patient is the higher serum CRP. Conclusion The independent risk factors of ACS in young women are hyperlipidemia, hyperhomocysteinemia, overweight, high CRP, hypertension, hypothyroidism, gynecological diseases, depression or anxiety, cardiac insufficiency, hypercholesterolemia, diabetes, oral contraceptives, family history of early-onset CHD, and autoimmune diseases. The co-existence of multiple risk factors is the main cause suffering from ACS in young women.

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Section: Discussionsupporting

confidence: 90%

Section: The Judging Criteria For Risk Factorsmentioning

confidence: 99%

The characteristics of risk factors in Chinese young women with acute coronary syndrome

Liu

Zhou

et al. 2020

BMC Cardiovasc Disord

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“…Many prospective cohort studies have described traditional risk factors for incident coronary heart disease (CHD) 1) . In 1961, the Framingham Heart Study, the first well-designed large-scale cardiovascular cohort study, identified major risk factors for CHD, including high blood pressure, high cholesterol level, and left ventricular hypertrophy.…”

Section: See Article Vol 27: 669-682mentioning

confidence: 99%

Small-Dense Low-Density Lipoprotein Cholesterol: A Subclinical Marker for the Primary Prevention of Coronary Heart Disease

Kokubo

Watanabe

Higashiyama

et al. 2020

JAT

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“…In this regard, the Framingham Heart Study is the first and the longest longitudinal transgenerational cohort study that began in 1948 and is ongoing now. During the last decade, in a framework of the Framingham Heart Study, detailed cohort profiles have been created using omics technologies such as whole-genome sequencing, DNA methylation analysis, transcriptome analysis, high-throughput proteomics and metabolomics, and microbiome studies [35].…”

Section: здравоохранение ориентированное на улучшение здоровья местнmentioning

confidence: 99%

“…В этом отношении показательным является Фрамингемское исследование сердечно-сосудистых заболеваний -первое и самое длительное продольное трансгенерационное когортное исследование, начавшееся в 1948 г. и продолжающееся до сих пор. В течение последнего десятилетия в рамках Фрамингемского исследования создают углубленные профили когорт, используя омиксные технологии, такие как полногеномное секвенирование, анализ метилирования ДНК, транскриптомный анализ, высокопроизводительная протеомика и метаболомика и исследования микробиома [35].…”

Section: Social Factors and Cardiovascular Predictorsunclassified

Emerging trends and challenges of population-based cardiology

Анфиногенова¹,

Трубачева²,

Серебрякова³

et al. 2020

SMJ

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Научно-исследовательский институт кардиологии, Томский национальный исследовательский медицинский центр Российской академии наук, 634012, Российская Федерация, Томск, ул. Киевская, 111а Аннотация Целью статьи является обзор зарубежной литературы относительно современных трендов и вызовов в области эпидемиологии сердечно-сосудистых заболеваний (ССЗ), включая появление новых факторов риска. Рассмотрено трансформирующее влияние омиксных технологий на эпидемиологию, сильные и слабые стороны метаэпидемиологии, а также роль мобильных технологий и электронных медицинских карт в укреплении здоровья населения. Отмечена важность преемственности между результатами эпидемиологических исследований и программами, ориентированными на улучшение здоровья местного населения. Авторы делают вывод, что изменение образа жизни людей в индустриальном обществе, глобализация, процессы миграции, бурное развитие технологий и промышленности сопровождаются трансформацией старых и появлением новых факторов риска ССЗ, требующих последовательного изучения и контроля. Революционные изменения в области биомедицинских технологий и эпидемиологических методов находят отражение в расширении международной терминологии. Учитывая, что новые термины рождаются на стыке трансформирующих направлений науки, авторы считают необходимым обновление и расширение российской терминологии в области эпидемиологии и смежных дисциплин наряду с внедрением новых биомедицинских подходов. Ключевые слова: сердечно-сосудистые заболевания, эпидемиология, омиксные технологии, новые подходы, факторы риска. Конфликт интересов: авторы заявляют об отсутствии конфликта интересов. Прозрачность финансовой деятельности: никто из авторов не имеет финансовой заинтересованности в представленных материалах или методах.

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70-year legacy of the Framingham Heart Study

Cited by 205 publications

References 197 publications

The characteristics of risk factors in Chinese young women with acute coronary syndrome

The characteristics of risk factors in Chinese young women with acute coronary syndrome

Small-Dense Low-Density Lipoprotein Cholesterol: A Subclinical Marker for the Primary Prevention of Coronary Heart Disease

Emerging trends and challenges of population-based cardiology

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