703 Gut-Homing CD4+ Lymphocytes Are Specifically Targeted in Cynomolgus Monkeys Dosed with Anti-Beta7 Antibodies

Fuh, Franklin; David, Clarissa; Hwang, Olivia; Gadkari, Shweta; Nguyen, Quyen; Takahashi, Chikara; Lutman, Jeffery; Pham, Khanh; Storn, Anahid; Howell, Kathleen; Berry, Karen; O’Byrne, Sharon; Danilenko, Dimitry M.; Gelzleichter, Thomas; Wang, Hong; Stefanich, Eric; Williams, Marna

doi:10.1016/s0016-5085(08)60465-5

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“…These data are consistent with the PD response of cynomolgus monkeys exposed to the dual α 4 β 7 and α E β 7 antagonist etrolizumab (rhuMAb Beta7). Etrolizumab also elevated the level of this same subset in the vasculature, ≈3–6‐fold over preexposure levels 8, 13…”

Section: Discussionmentioning

confidence: 99%

“…Natalizumab (Tysabri, Biogen Idec, Cambridge, MA)4 binds the α 4 chain independently of the associated β chain and antagonizes both the pleiotropic α 4 β 1 and the gut‐tropic α 4 β 7 integrin 5–7. Etrolizumab (rhuMAb beta7) binds the β 7 chain independently of the associated α chain and antagonizes both the α E β 7 and α 4 β 7 integrins 8. Vedolizumab (Millennium Pharmaceuticals, Cambridge, MA) is unique in that it antagonizes the gut‐tropic α 4 β 7 integrin exclusively 9.…”

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confidence: 99%

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Conserved MicroRNAs in Chinese hamster ovary cell lines

Johnson

Jacob

Nissom

et al. 2010

Biotech & Bioengineering

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MicroRNAs (miRNAs), a class of short (20-24 nt) non-coding RNAs that direct post-transcriptional repression of messenger RNAs, increasingly have been shown to play a key role in regulating cellular physiology. We investigated the prevalence of miRNAs in Chinese hamster ovary (CHO) cells by high-throughput sequencing. Six cDNA libraries of small RNAs from four CHO cell lines were constructed and sequenced by Illumina sequencing. Three hundred fifty distinct miRNA and miRNA* sequences were identified through homology with other species, including mouse, rat, and human. While the majority of the identified miRNAs appear to be expressed ubiquitously, many miRNAs were found to have a wide range of expression levels between cell lines. The identification of these miRNAs will facilitate investigations of their contribution to the hyperproductivity trait.

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confidence: 99%

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confidence: 99%