75 years of bovine viral diarrhea virus: Current status and future applications of the use of directed antivirals

Newcomer, Benjamin W.

doi:10.1016/j.antiviral.2021.105205

Cited by 10 publications

(2 citation statements)

References 91 publications

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“…Pestiviruses remain a source of major financial and production losses in the livestock industry worldwide, making their eradication an important objective of veterinary research (Newcomer, 2021). Vaccines approved for pestiviruses are mostly live attenuated vaccines.…”

Section: Discussionmentioning

confidence: 99%

Rice‐produced classical swine fever virus glycoprotein E2 with herringbone‐dimer design to enhance immune responses

Yang

et al. 2023

Plant Biotechnology Journal

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SummaryPestiviruses, including classical swine fever virus, remain a concern for global animal health and are responsible for major economic losses of livestock worldwide. Despite high levels of vaccination, currently available commercial vaccines are limited by safety concerns, moderate efficacy, and required high doses. The development of new vaccines is therefore essential. Vaccine efforts should focus on optimizing antigen presentation to enhance immune responses. Here, we describe a simple herringbone‐dimer strategy for efficient vaccine design, using the classical swine fever virus E2 expressed in a rice endosperm as an example. The expression of rE2 protein was identified, with the rE2 antigen accumulating to 480 mg/kg. Immunological assays in mice, rabbits, and pigs showed high antigenicity of rE2. Two immunizations with 284 ng of the rE2 vaccine or one shot with 5.12 μg provided effective protection in pigs without interference from pre‐existing antibodies. Crystal structure and small‐angle X‐ray scattering results confirmed the stable herringbone dimeric conformation, which had two fully exposed duplex receptor binding domains. Our results demonstrated that rice endosperm is a promising platform for precise vaccine design, and this strategy can be universally applied to other Flaviviridae virus vaccines.

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Section: Discussionmentioning

confidence: 99%

Rice‐produced classical swine fever virus glycoprotein E2 with herringbone‐dimer design to enhance immune responses

Yang

et al. 2023

Plant Biotechnology Journal

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“…The Pestivirus genus also contains more animal pathogens, such as the border disease virus (BDV) and the classical swine fever virus (CSFV) [2]. Not only can cows be the host of BVDV, but pigs, sheep, goats and other wild and domestic ruminants can also be infected [3]. BVDV causes teratogenesis, abortion, early embryonic death, immune system and respiratory disorders in cows, resulting in acute infections of immunocompetent cattle, giving rise to a mortality rate ranging from approximately 20 to 30% [4] and an estimated economical loss of approximately 10 and 40 million dollars per million calvings.…”

Section: Introductionmentioning

confidence: 99%

Benzimidazole-2-Phenyl-Carboxamides as Dual-Target Inhibitors of BVDV Entry and Replication

Ibba

Riu

Delogu

et al. 2022

Viruses

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Bovine viral diarrhea virus (BVDV), also known as Pestivirus A, causes severe infection mostly in cattle, but also in pigs, sheep and goats, causing huge economical losses on agricultural farms every year. The infections are actually controlled by isolation of persistently infected animals and vaccination, but no antivirals are currently available to control the spread of BVDV on farms. BVDV binds the host cell using envelope protein E2, which has only recently been targeted in the research of a potent and efficient antiviral. In contrast, RdRp has been successfully inhibited by several classes of compounds in the last few decades. As a part of an enduring antiviral research agenda, we designed a new series of derivatives that emerged from an isosteric substitution of the main scaffold in previously reported anti-BVDV compounds. Here, the new compounds were characterized and tested, where several turned out to be potent and selectively active against BVDV. The mechanism of action was thoroughly studied using a time-of-drug-addition assay and the results were validated using docking simulations.

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Development of an indirect ELISA for the serologic detection of bovine viral diarrhea virus based on E2 antigen sub-genotypes 1b, 1e, and 1d

Manrique-Suárez,

Gutiérrez,

Hidalgo-Gajardo

et al. 2024

Trop Anim Health Prod

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75 years of bovine viral diarrhea virus: Current status and future applications of the use of directed antivirals

Cited by 10 publications

References 91 publications

Rice‐produced classical swine fever virus glycoprotein E2 with herringbone‐dimer design to enhance immune responses

Rice‐produced classical swine fever virus glycoprotein E2 with herringbone‐dimer design to enhance immune responses

Benzimidazole-2-Phenyl-Carboxamides as Dual-Target Inhibitors of BVDV Entry and Replication

Development of an indirect ELISA for the serologic detection of bovine viral diarrhea virus based on E2 antigen sub-genotypes 1b, 1e, and 1d

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