76 Does supplemental protein and rumen-protected methionine improve performance and digestibility during late-gestation in beef cows?

Collins, Madeline; Shoveller, Anna K.; Mandell, I. B.; Lawson, Kaitlyn V J; Lievre, Michaela K S; Wood, Katharine M

doi:10.1093/jas/skz258.156

Cited by 3 publications

(4 citation statements)

References 69 publications

(159 reference statements)

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“…Methionine hydroxy analog supplementation during late gestation did not affect calf birth weight, which agrees with other studies in beef heifers ( Moriel et al, 2020 ) and cows ( Clements et al, 2017 ; Collins et al, 2019 ; Palmer et al, 2020 ). Periconceptional MHA supplementation did not affect calf birth weight ( Silva et al, 2021 ), but RPMet supplementation for 90 d prior to calving ( Moisá et al, 2019 ) tended to increase calf birth weight in primiparous females.…”

Section: Discussionsupporting

confidence: 91%

“…Glucose concentration was not affected by dietary treatment, agreeing with previous MHA supplementation in B. indicus -influenced beef heifers ( Moriel et al, 2020 ) and early lactating dairy cows ( Michelotti et al, 2021 ). Collins et al (2019) observed greater serum glucose during late gestational RPMet supplementation in beef cows; however, Palmer et al (2020) noted peripartum MHA supplementation resulted in lower glucose in lactation. Socha et al (2008) reported that glucose was not affected by methionine infusions during peak or mid lactation; however, a quadratic increase was observed during early lactation.…”

Section: Discussionmentioning

confidence: 93%

“…Methionine hydroxy analog supplementation at 15 g/d for approximately the last 60 d of gestation and first 30 d of lactation did not affect maternal BW or BCS in B. indicus -influenced heifers ( Moriel et al, 2020 ) or cows ( Palmer et al, 2020 ) grazing bahiagrass pastures. Studies in crossbred beef cows supplemented with MHA during late gestation ( Collins et al, 2019 ) or during the periconceptional period ( Silva et al, 2021 ) also reported no changes in maternal BW. The consistent lack of effects on maternal performance due to MHA supplementation, even in our M30 treatment that provided at least 50% more MHA than the previous studies, would suggest that a physiologically impactful dose was not reached or that cattle were not methionine deficient in those studies.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of peripartum supplementation of methionine hydroxy analogue on beef cow–calf performance

Redifer

Loy

Youngs

et al. 2023

Translational Animal Science

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The objective was to evaluate the effects of peripartum supplementation of a methionine hydroxy analogue (MHA) to primiparous, spring-calving beef females on dam and progeny performance. Angus heifers (n = 60) were blocked by expected parturition date, stratified by body weight (BW) and body condition score (BCS), and randomized to 1 of 15 pens. Pens were randomly assigned to 1 of 3 dietary treatments: a basal diet supplemented with 0 (M0), 15 (M15), or 30 (M30) g·animal-1·d-1MHA (provided as MFP feed supplement, Novus International Inc., St. Charles, MO). Diets were fed from 45 ± 13 (SD) d pre-calving through 81 ± 13 d postpartum (DPP), after which all cow-calf pairs were managed as a single group on pasture until weaning (199 ± 13 DPP). Dam BW, BCS, and blood samples were taken at 6 predetermined timepoints. Progeny data was collected at birth, 2 intermediate timepoints, and at weaning. Milk samples were collected for composition analysis at 7 ± 2 DPP and at 55 ± 5 DPP. Serial progesterone samples were analyzed to establish resumption of cyclicity, and ultrasonography was performed at 55 ± 5 DPP to evaluate ovarian function. Cows were bred via artificial insemination at 82 ± 13 DPP and subsequently exposed to bulls for a 55-d breeding season. Pen was the experimental unit, and preplanned orthogonal contrasts were tested (linear effect and M0 vs. M15 + M30). Dam BW and BCS were not affected by treatment (P ≥ 0.29) throughout the study. Week 1 milk fat concentration increased linearly (P = 0.05) and total solids tended to increase linearly (P = 0.07) as MHA increased; however, no other milk components were affected (P ≥ 0.16). Treatment did not affect (P ≥ 0.16) dam reproductive parameters or progeny performance from birth until weaning. Post-calving, circulating methionine equivalents tended to linearly increase (P = 0.10) with increasing MHA supplementation. At breeding, plasma urea N linearly decreased (P = 0.03) with increased supplementation of MHA, and plasma non-esterified fatty acids were less (P = 0.04) in MHA-supplemented dams compared with dams receiving no MHA. Maternal circulating glucose, glutathione peroxidase, and thiobarbituric acid-reactive substances were not affected (P ≥ 0.15) by treatment at any point. These data indicate that peripartum supplementation of MHA may increase milk fat composition shortly after calving, but MHA supplementation did not improve progeny growth or dam reproductive performance in the current study.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of peripartum supplementation of methionine hydroxy analogue on beef cow–calf performance

Redifer

Loy

Youngs

et al. 2023

Translational Animal Science

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“…Maternal AA supply during late gestation affects neonatal calf performance and immune responses ( 12 , 53 , 61 ), which agrees with the results from the current study. Nutrients in the diets of pregnant dairy cows are repartitioned toward colostrum production or fetal growth ( 62 ). Supplying RPM to pre-calving dairy cows affects fetal programming via changes in placental metabolism ( 63 ), and RPL may follow the exact mechanism.…”

Section: Discussionmentioning

confidence: 99%

Maternal Supply of Ruminally-Protected Lysine and Methionine During Close-Up Period Enhances Immunity and Growth Rate of Neonatal Calves

Wang

Elsaadawy

et al. 2021

Front. Vet. Sci.

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The objective of this study was to evaluate the effect of supplying ruminally-protected lysine (RPL), methionine (RPM), or the two in combination (RPML) to transition dairy cows on the immunity and performance of their offspring. Eighty heifer calves (n = 20 calves per group) were assigned to four treatments based on their dam diet; basal diet (CON), a basal diet with lysine [RPL, 0.33% of dry matter (DM)], a basal diet with methionine (RPM, 0.16% DM), or with the combination (RPML). Calves were fed colostrum from their dams within 2 h of birth. Calves were then fed milk only (d 2–22), a combination of milk and milk replacer (d 23–25), and milk replacer (d 25–60). Starter feed was fed to the calves twice daily after liquid feeding. Calves blood samples were collected after calving on 0, 12, 24, and 48 h and 5 and 7 d after birth. Data were analyzed by SAS software v9.4. Providing ruminally-protected amino acids (RPAA) to transition cows improved colostrum quality compared to the CON (Brix; P < 0.01). Serum total protein concentrations were higher in calves from supplemented cows than in calves from unsupplemented cows (P < 0.01). Calves born to dams in the RPM, RPL, and RPML groups had higher plasma immunoglobulin G (IgG) concentrations 0, 12, 24, and 48 h and 7 d after birth than those born to dams in the CON group (P < 0.05). The percentage of calves with adequate passive immunity transfer was increased with RPM and RPL or the two in combination (P < 0.01). However, there was no difference in the percentage of calves with adequate passive immunity transfer between the RPM and RPL groups (P = 0.21). Calves from cows that receive supplemental RPAA have a greater average daily gain (ADG) than those born to cows in the CON group (P < 0.01). These results indicate that maternal supplementation with RPM or RPL or the two in combination during the periparturient period could be an alternative strategy to improve the performance of calves, especially in accelerated growth programs in calves.

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Disrupted one-carbon metabolism in heifers negatively affects their health and physiology

Crouse,

Trotta,

Freetly

et al. 2024

Journal of Animal Science

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The objective of this study was to determine the dose-dependent response of one-carbon metabolite (OCM: methionine, choline, folate, and vitamin B12) supplementation on heifer dry matter intake on fixed gain, organ mass, hematology, cytokine concentration, pancreatic and jejunal enzyme activity, and muscle hydrogen peroxide production. Angus heifers (n = 30; BW = 392.6 ± 12.6 kg) were individually fed and assigned to one of five treatments: 0XNEG: Total mixed ration (TMR) and saline injections at d 0 and 7 of the estrous cycle, 0XPOS: TMR, rumen protected methionine (MET) fed at 0.08% of the diet dry matter, rumen protected choline (CHOL) fed at 60 g/d, and saline injections at d 0 and 7, 0.5X: TMR, MET, CHOL, 5-mg B12, and 80-mg folate injections at d 0 and 7, 1X: TMR, MET CHOL, 10-mg vitamin B12, and 160-mg folate at d 0 and 7, and 2X: TMR, MET, CHOL, 20-mg vitamin B12, and 320-mg folate at d 0 and 7. All heifers were estrus synchronized but not bred, and blood samples were collected on d 0, 7, and at slaughter (d 14) during which tissues were collected. By design, heifer ADG did not differ (P = 0.96). Spleen weight and uterine weight were affected cubically (P = 0.03) decreasing from 0XPOS to 0.5X. Ovarian weight decreased linearly (P < 0.01) with increasing folate and B12 injection. Hemoglobin and hematocrit percentage were decreased (P < 0.01) in the 0.5X treatment compared with all other treatments. Plasma glucose, histotroph protein, and pancreatic α-amylase were decreased (P ≤ 0.04) in the 0.5X treatment. Heifers on the 2X treatment had greater pancreatic α-amylase compared with 0XNEG and 0.5X treatment. Interleukin-6 in plasma tended (P = 0.08) to be greater in the 0XPOS heifers compared with all other treatments. Lastly, 0XPOS-treated heifers had reduced (P ≤ 0.07) hydrogen peroxide production in muscle compared with 0XNEG heifers. These data imply that while certain doses of OCM do not improve whole animal physiology, OCM supplementation doses that disrupt one-carbon metabolism, such as that of the 0.5X treatment, can induce a negative systemic response that result in negative effects in both the dam and the conceptus during early gestation. Therefore, it is necessary to simultaneously establish an optimal OCM dose that increases circulating concentrations for use by the dam and the conceptus, while avoiding potential negative side effects of a disruptive OCM, to evaluate the long-term impacts of OCM supplementation of offspring programming.

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76 Does supplemental protein and rumen-protected methionine improve performance and digestibility during late-gestation in beef cows?

Cited by 3 publications

References 69 publications

Evaluation of peripartum supplementation of methionine hydroxy analogue on beef cow–calf performance

Evaluation of peripartum supplementation of methionine hydroxy analogue on beef cow–calf performance

Maternal Supply of Ruminally-Protected Lysine and Methionine During Close-Up Period Enhances Immunity and Growth Rate of Neonatal Calves

Disrupted one-carbon metabolism in heifers negatively affects their health and physiology

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