776 CO2-Insufflation During Single Balloon-Enteroscopy: a Randomized European Multicenter Trial

Lenz, Philipp; Meister, Tobias; Manno, Mauro; Pennazio, Marco; Conigliaro, Rita; Lebkücher, Sven; Ullerich, Hansjoerg; Schmedt, Andre; Floer, Martin; Beyna, Tors﻿ten; Lenze, Frank; Domagk, Dirk

doi:10.1016/j.gie.2013.04.125

Cited by 4 publications

(7 citation statements)

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“…It is well known that carbon dioxide (CO2) is absorbed faster in the body than air and is also rapidly excreted through the lungs, except in cases of pulmonary dysfunction. Therefore, CO2 insufflation is expected to reduce the pain and abdominal discomfort associated with endoscopic examination and therapy [18][19][20][21][22][23][24][25] . Perforation and major bleeding are severe complications of ESD.…”

Section: Introductionmentioning

confidence: 99%

Safety and efficacy of carbon dioxide insufflation during gastric endoscopic submucosal dissection

Takada

Araki

Onogi

et al. 2015

WJG

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Section: Introductionmentioning

confidence: 99%

Safety and efficacy of carbon dioxide insufflation during gastric endoscopic submucosal dissection

Takada

Araki

Onogi

et al. 2015

WJG

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“…5 Lenz et al reported abdominal pain was reduced in the CO 2 group at 1 and 3 h after the procedure, but only reached statistical significance at 1 h after the anal procedure. 7 Hirai et al reported that VAS at 1 h after the procedure tended to be lower in the CO 2 group, but without any significant difference. 6 Li et al reported there was no significant difference between CO 2 group and air group.…”

Section: Discussionmentioning

confidence: 94%

“…7,17 A prospective European multicenter study reported the procedure failure in five of 35 patients (14%). 18 Mehdizadeh et al reported that the technical failure rate was 16%.…”

Section: Discussionmentioning

confidence: 99%

“…However, there was also significant heterogeneity among the trial results (I 2 ¼ 79.2%, p ¼ 0.008). Although Domagk et al 5 and Li et al 8 excluded cases with previous abdominal surgery or narrow strictures in proximal jejunum, Lenz et al 7 included patients with previous abdominal surgery. Lenz et al 7 reported that the oral insertion depth was significantly lower in patients with previous abdominal surgery than in patients without such a history.…”

Section: Intubation Depthmentioning

confidence: 99%

“…5 However, other studies produced inconsistent results. [6][7][8] The number of patients enrolled in some trials has been too few to achieve statistically conclusive results. We proposed that systematically pooling data from all published reports might provide a better understanding of the efficacy of CO 2 insufflation for balloon-assisted enteroscopy.…”

Section: Introductionmentioning

confidence: 99%

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Effects of carbon dioxide insufflation in balloon‐assisted enteroscopy: A systematic review and meta‐analysis

et al. 2016

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Background and aim: The efficacy of CO 2 insufflation during balloon-assisted enteroscopy remains controversial. This study aimed to perform a systematic review with meta-analysis of randomized controlled trials (RCTs) in which CO 2 insufflation was compared with air insufflation in balloon-assisted enteroscopy. Methods: PubMed, the Cochrane library, and the Igaku-Chuo-Zasshi database were searched to identify RCTs eligible for inclusion in the systematic review. Data from the eligible studies were combined to calculate the pooled odds ratios (ORs) or weighted mean differences (WMDs) with 95% confidence intervals (CIs). Results: Four RCTs (461 patients) were identified. Compared with air insufflation, CO 2 insufflation significantly increased intubation depth of oral enteroscopy (WMD: 55.2, 95% CI: 10.77-99.65, p ¼ 0.015). However, there was significant heterogeneity. The intubation depth of anal enteroscopy showed no significant difference between the CO 2 group and the air group. CO 2 insufflation significantly reduced abdominal pain compared with air insufflation (WMD: À2.463, 95% CI: À4.452 to À0.474, p ¼ 0.015), without significant heterogeneity. The PaCO 2 or end-tidal CO 2 level showed no significant difference between the CO 2 group and air group. Conclusions: Compared with air insufflation, CO 2 insufflation during balloon-assisted enteroscopy caused less postprocedural pain without CO 2 retention.

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Capsule endoscopy and deep enteroscopy

Gerson

2013

Gastrointestinal Endoscopy

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776 CO2-Insufflation During Single Balloon-Enteroscopy: a Randomized European Multicenter Trial

Cited by 4 publications

References 0 publications

Safety and efficacy of carbon dioxide insufflation during gastric endoscopic submucosal dissection

Safety and efficacy of carbon dioxide insufflation during gastric endoscopic submucosal dissection

Effects of carbon dioxide insufflation in balloon‐assisted enteroscopy: A systematic review and meta‐analysis

Capsule endoscopy and deep enteroscopy

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