1999
DOI: 10.2307/3434629
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8-Hydroxy-2 prime -Deoxyguanosine, A Major Mutagenic Oxidative DNA Lesion, and DNA Strand Breaks in Nasal Respiratory Epithelium of Children Exposed to Urban Pollution

Abstract: Southwest metropolitan Mexico City children are repeatedly exposed to high levels of a complex mixture of air pollutants, including ozone, particulate matter, aldehydes, metals, and nitrogen oxides. We explored nasal cell 8-hydroxy-2'-deoxyguanosine (8-OHdG), a major mutagenic lesion producing G-->T transversion mutations, using an immunohistochemical method, and DNA single strand breaks (ssb) using the single cell gel electrophoresis assay as biomarkers of oxidant exposure. Nasal biopsies from the posterior i… Show more

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Cited by 7 publications
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“…8 Levels of 8-oxo-dG can also be readily quantified by immunohistochemical techniques. This method has been used to identify levels of 8-oxo-dG in nasal biopsies of children in Mexico exposed to high levels of air pollutants 9 as well as in oral mucosal cells in smokers versus nonsmokers.…”
mentioning
confidence: 99%
“…8 Levels of 8-oxo-dG can also be readily quantified by immunohistochemical techniques. This method has been used to identify levels of 8-oxo-dG in nasal biopsies of children in Mexico exposed to high levels of air pollutants 9 as well as in oral mucosal cells in smokers versus nonsmokers.…”
mentioning
confidence: 99%