8-Isoprostane F2α excretion is reduced in women by increased vegetable and fruit intake

Thompson, Henry J.; Heimendinger, Jerianne; Sedlacek, Scot; Haegele, Albert D.; Diker, Ann; O’Neill, Caitlin; Meinecke, Becky; Wolfe, Pamela; Zhu, Zongjian; Jiang, Weiqin

doi:10.1093/ajcn/82.4.768

Cited by 76 publications

(43 citation statements)

References 16 publications

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“…The decrease in the combination arm was statistically significant when the seven samples with very high readings on the ELISA were included, but those data were not used in the final model because these samples were above the limits of the calibration curve and therefore could not be quantified accurately. Other studies have shown that dietary or antioxidant interventions tend to be more effective on decreasing oxidative stress in individuals who have higher initial oxidative stress levels (48,49), and here, mean baseline levels were highest in the combination arm.…”

Section: Resultssupporting

confidence: 56%

Effects of High Fruit-Vegetable and/or Low-Fat Intervention on Breast Nipple Aspirate Fluid Micronutrient Levels

Djurić

Chen

Ren

et al. 2007

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: A change in diet is known to affect micronutrient levels in blood but to what extent diet can affect micronutrient levels in the breast is not yet well established. Methods: Healthy, premenopausal women with a family history of breast cancer were randomized across four diet arms for 1 year in a 2 Â 2 factorial design study: control, low-fat, high fruit-vegetable, and combination low-fat/high fruit-vegetable diets. Subjects were asked to collect breast nipple aspirate fluid (NAF) at 0, 6, and 12 months, and levels of micronutrients were measured in the fluid. Results: A total of 122 women were enrolled, 97 were retained for 12 months, and sufficient NAF for analysis was available from 59 women at baseline, 49 at 6 months, and 50 at 12 months. Repeated measures mixed-model ANOVA was used to model the data using cholesterol levels and lactation

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Section: Resultssupporting

confidence: 56%

Effects of High Fruit-Vegetable and/or Low-Fat Intervention on Breast Nipple Aspirate Fluid Micronutrient Levels

Djurić

Chen

Ren

et al. 2007

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…WATZL et al [12] demonstrated a significant reduction in plasma CRP following 4 weeks on a high-FV diet in healthy nonsmoking males, and a 2-yr Mediterranean-style dietary intervention in patients with metabolic syndrome significantly lowered serum levels of CRP, IL-6, IL-7 and IL-18 [32]. THOMPSON et al [13] reported a reduction in the excretion of 8-isoprostanes after an 8-week high-FV diet in healthy females. However, two recent intervention studies, a 2-month Mediterranean diet intervention [33] and a 2-month FV intervention [26], showed no effect of increased FV intake on circulating CRP, yet these studies were able to demonstrate significant improvements in measures of vascular function (flow-mediated dilatation and venous occlusion plethysmography, respectively), thus indicating that such biomarkers may be dissociated from true biological effects and, therefore, may be of limited use in dietary studies [31].…”

Section: Discussionmentioning

confidence: 99%

“…A 12-week period was chosen for this study as this has been shown to be sufficient time to ensure an increase in micronutrient status [11] in response to FV interventions, and also to induce changes in plasma C-reactive protein (CRP) and urinary isoprostanes [12,13]. Interleukin (IL)-8 has recently been shown to be responsive to 10-week dietary interventions (with bread [14] and cheese [15]).…”

Section: Methodsmentioning

confidence: 99%

Effect of fruit and vegetable intake on oxidative stress and inflammation in COPD: a randomised controlled trial

Baldrick¹,

Elborn²,

Woodside³

et al. 2011

Eur Respir J

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Epidemiological evidence supports a positive relationship between fruit and vegetable (FV) intake, lung function and chronic obstructive pulmonary disease (COPD). Increasing FV intake may attenuate the oxidative stress and inflammation associated with COPD.An exploratory randomised controlled trial to examine the effect of increased consumption of FV on oxidative stress and inflammation in moderate-to-severe COPD was conducted. 81 symptomatically stable patients with a habitually low FV intake (two or fewer portions of FV per day) were randomised to the intervention group (five or more portions of FV per day) or the control group (two or fewer portions of FV per day). Each participant received self-selected weekly home deliveries of FV for 12 weeks.75 participants completed the intervention. There was a significant between-group change in self-reported FV intake and biomarkers of FV intake (zeaxanthin (p50.034) and b-cryptoxanthin (p50.015)), indicating good compliance; post-intervention intakes in intervention and control groups were 6.1 and 1.9 portions of FV per day, respectively. There were no significant changes in biomarkers of airway inflammation (interleukin-8 and myeloperoxidase) and systemic inflammation (C-reactive protein) or airway and systemic oxidative stress (8-isoprostane).This exploratory study demonstrated that patients with moderate-to-severe COPD were able to comply with an intervention to increase FV intake; however, this had no significant effect on airway or systemic oxidative stress and inflammation.

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“…Investigators have reported that urinary levels of F 2 -isoprostane were significantly reduced among healthy women consuming 9e10 portions of fruit and vegetables daily for 8 weeks [38]. Since these investigators recruited non-smoking, medication-free volunteers from a womens' health group, extrapolation to the current cohort is difficult.…”

Section: Discussionmentioning

confidence: 99%

The effect of increased dietary fruit and vegetable consumption on endothelial activation, inflammation and oxidative stress in hypertensive volunteers

McCall¹,

McGartland²,

McKinley³

et al. 2011

Nutrition, Metabolism and Cardiovascular Diseases

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8-Isoprostane F2α excretion is reduced in women by increased vegetable and fruit intake

Abstract: A significant reduction in the excretion of 8-iso-PGF2alpha was induced by the run-in diet and the high-VF diet. The degree of reduction was related to the subject's baseline urinary concentration of 8-iso-PGF2alpha.

Cited by 76 publications

References 16 publications

Effects of High Fruit-Vegetable and/or Low-Fat Intervention on Breast Nipple Aspirate Fluid Micronutrient Levels

Effects of High Fruit-Vegetable and/or Low-Fat Intervention on Breast Nipple Aspirate Fluid Micronutrient Levels

Effect of fruit and vegetable intake on oxidative stress and inflammation in COPD: a randomised controlled trial

The effect of increased dietary fruit and vegetable consumption on endothelial activation, inflammation and oxidative stress in hypertensive volunteers

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