8. Low-Intensity Pulsed Ultrasound (LIPUS) Treatment for the Patient With Bone Reconstruction by the Masquelet Technique Using RIA

Niikura, Takahiro; S, Yang Lee; Iwakura, Tomohiro; Kurosaka, Masahiro

doi:10.1097/01.bot.0000489981.32706.91

Cited by 6 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Low-intensity pulsed ultrasound (LIPUS) is a form of physical therapy primarily recognized for its non-thermal effects, which are advantageous for tissue healing. Extensive research has demonstrated its efficacy in promoting bone healing, 8 treating soft tissue injuries, 9 and restoring ovarian function in cases of failure. 10 11 The mechanism by which LIPUS alleviates premature ovarian failure is through the inhibition of apoptosis in ovarian granulosa cells.…”

Section: Introductionmentioning

confidence: 99%

Effects of insonification on repairing the renal injury of diabetic nephropathy rats

Xiao,

Wu,

Deng

et al. 2024

BMJ Open Diab Res Care

View full text Add to dashboard Cite

IntroductionProlonged hyperglycemia in diabetes mellitus can result in the development of diabetic nephropathy (DN) and increase the susceptibility to kidney failure. Low-intensity pulsed ultrasound (LIPUS) is a non-invasive modality that has demonstrated effective tissue repair capabilities. The objective of this study was to showcase the reparative potential of LIPUS on renal injury at both animal and cellular levels, while also determining the optimal pulse length (PL).Research design and methodsWe established a rat model of DN, and subsequently subjected the rats’ kidneys to ultrasound irradiation (PL=0.2 ms, 10 ms, 20 ms). Subsequently, we assessed the structural and functional changes in the kidneys. Additionally, we induced podocyte apoptosis and evaluated its occurrence following ultrasound irradiation.ResultsFollowing irradiation, DN rats exhibited improved mesangial expansion and basement membrane thickening. Uric acid expression increased while urinary microalbumin, podocalyxin in urine, blood urea nitrogen, and serum creatinine levels decreased (p<0.05). These results suggest that the optimal PL was 0.2 ms. Using the optimal PL further demonstrated the reparative effect of LIPUS on DN, it was found that LIPUS could reduce podococyte apoptosis and alleviate kidney injury. Metabolomics revealed differences in metabolites including octanoic acid and seven others and western blot results showed a significant decrease in key enzymes related to lipolysis (p<0.05). Additionally, after irradiating podocytes with different PLs, we observed suppressed apoptosis (p<0.05), confirming the optimal PL as 0.2 ms.ConclusionsLIPUS has been demonstrated to effectively restore renal structure and function in DN rats, with an optimal PL of 0.2 ms. The mechanism underlying the alleviation of DN by LIPUS is attributed to its ability to improve lipid metabolism disorder. These findings suggest that LIPUS may provide a novel perspective for future research in this field.

show abstract

Section: Introductionmentioning

confidence: 99%

Effects of insonification on repairing the renal injury of diabetic nephropathy rats

Xiao,

Wu,

Deng

et al. 2024

BMJ Open Diab Res Care

View full text Add to dashboard Cite

show abstract

“…Whether antibiotics should be included remains greatly debated 12 , 13 . Many studies have recommended the use of antibiotic-loaded PMMA cement during the first stage of Masquelet 14 – 16 . Additionally, a systematic review and a meta-analysis have also suggested that the antibiotic-loaded PMMA cement might prevent repeated surgeries for bone grafting 17 .…”

Section: Introductionmentioning

confidence: 99%

Effects of PMMA spacer loaded with varying vancomycin concentrations on bone regeneration in the Masquelet technique

Xie

Fan

et al. 2022

Sci Rep

View full text Add to dashboard Cite

Whether antibiotics should be included remains greatly debated in Masquelet technique. This study intended to determine the effect of polymethyl methacrylate (PMMA) spacer loaded with different vancomycin concentrations on bone defect repair. Hollow cylindrical spacers consisting of PMMA and varying vancomycin concentrations (0, 1, 2, 4, 6, 8, and 10 g) were prepared. Critical bone defects of rabbits were created at the radial shaft, and spacers were implanted and subsequently intramedullary fixed with retrograde Kirschner’s wires (n = 4 for each vancomycin concentration). After 4 weeks, the induced membranes were opened and cancellous allografts were implanted into the defects. Eight weeks post-operatively, the results of X-ray, histology, and micro-CT revealed that some cortical bone was formed to bridge the gap and the bone marrow cavity was formed over time. Quantitatively, there was more new bone formation in the groups with a relatively lower vancomycin concentration (1–4 g) compared with that in the groups with a higher vancomycin concentration (6–10 g). Our findings suggested that PMMA spacers loaded with relatively lower vancomycin concentrations (1–4 g) did not interfere with new bone formation, whereas spacers loaded with relatively higher vancomycin concentrations (6–10 g) had negative effects on bone formation.

show abstract

Mechanisms of the Masquelet technique to promote bone defect repair and its influencing factors

Wu,

Bao,

Wang

et al. 2024

Chinese Journal of Traumatology

View full text Add to dashboard Cite

8. Low-Intensity Pulsed Ultrasound (LIPUS) Treatment for the Patient With Bone Reconstruction by the Masquelet Technique Using RIA

Abstract: LIPUS may be used as an adjuvant therapy for a patient treated by the Masquelet technique using RIA.

Cited by 6 publications

References 0 publications

Effects of insonification on repairing the renal injury of diabetic nephropathy rats

Effects of insonification on repairing the renal injury of diabetic nephropathy rats

Effects of PMMA spacer loaded with varying vancomycin concentrations on bone regeneration in the Masquelet technique

Mechanisms of the Masquelet technique to promote bone defect repair and its influencing factors

Contact Info

Product

Resources

About