8-Methoxyneorautenol and radical scavenging flavonoids from Erythrina abyssinica

Yenesew, Abiy; Twinomuhwezi, Hannington; Kiremire, Bernard T.; Mbugua, Martin N.; Gitu, Peter M.; Heydenreich, Matthias; Peter, Martin G.

doi:10.4314/bcse.v23i2.44963

Cited by 18 publications

(16 citation statements)

References 12 publications

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“…This plant species finds extensive application in traditional medicine and is used in the preparation of health tonics by the Maasai community of East Africa [31,32]. In addition, this plant is shown to be rich in flavonoids, a group of natural products known to be efficacious in the management of NAFLD and other metabolic syndrome conditions [33][34][35][36].…”

Section: Discussionmentioning

confidence: 99%

“…In addition, fifteen pterocarpan derivatives which possess inhibitory effects on protein tyrosine phosphatase 1B (PTP1B) have been isolated from the stem bark of this plant species [33,38].…”

Section: Discussionmentioning

confidence: 99%

“…The freeze-dried extracts of Erythrina abyssinica had significant protective effects against the development of NAFLD in this study and show potential as a prophylactic against the development of this condition. These beneficial actions can be attributed to the rich variety of chemical compounds found in this plant species which have been shown to have positive effects in metabolic syndromes, cardiovascular disease and other conditions associated with aging [33,35,38,41,55].…”

Section: Discussionmentioning

confidence: 99%

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Hepatoprotective effects ofErythrina abyssinicaLam Ex Dc against Non Alcoholic Fatty Liver Disease in Sprague Dawley Rats

Yenesew

et al. 2019

Preprint

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Background: Non-alcoholic fatty liver disease (NFLD) is the hepatic manifestation of the metabolic syndrome recognized as the most prevalent chronic liver disease across all age groups. NFLD is strongly associated with obesity, insulin resistance, hypertension and dyslipidemia. Extensive research efforts are geared, through pharmacological approach, towards preventing or reversing this. Erythrina abyssinica Lam ex DC is an indigenous tree used widely used in traditional medicine, including for the treatment of liver related diseases, and has been shown to possess hypoglycemic, anti-oxidant, antimicrobial and anti-plasmodia effects. The present study is aimed at establishing the effects of E. abyssinica on the development of Non-alcoholic fatty liver disease induced by a high-fat and high-sugar diet in rats, in-vivo model. (40) were randomly divided into five groups: positive control (pioglitazone), Negative control (high fat/high sugar diet), low test dose (200 mg/kg), high test dose (400 mg/kg) and normal group (standard chow pellets and fresh water). Methods: Forty ratsThe inhibitory effect of the stem bark extract of E. abyssinica on the development of NAFLD was evaluated by chronic administration the herb extracts to rats on a high-fat/high-sugar diet.Biochemical indices of hepatic function including serum lipid profile, serum aspartate transaminase and alanine transaminase levels were then determined. Histological analysis of liver samples was carried out to quantify the degree of steato-hepatitis. Liver weights were taken and used to determine the hepatic index. The data was analyzed using one-way ANOVA, and Tukey's post-hoc tests were done in cases of significance. Histology data was analyzed using Kruskal-Wallis and Dunn's post-hoc test was done in cases of significance. Significance was set at p<0.05. Results:The freeze dried extract of E. abyssinica had significant effects on fasting blood glucose [5.43 ± 0.17 (HF/HSD) vs 3.8 ± 0.15 (E 400 mg/kg) vs 4.54 ± 0.09 (E 200 mg/kg) vs. 4.16 ± 0.13 (PIOG) vs. 2.91 ± 0.16 (normal control): P value < 0.0001], and insulin sensitivity [329.4 ± 13.48 mmol/L · min (HF/HSD) vs. 189.8 ± 12.11 mmol/L · min (E 400 mg/kg) vs. 233.8 ± 6.55 mmol/L · min (E 200 mg/kg) vs. 211.1 ± 7.35 mmol/L · min (PIOG) vs. 142.9 ± 11.94 mmol/L · min: P value < 0.0001],The extract had significant effects on hepatic indices including, hepatic triglycerides (P value < 0.0001), liver weights (P value < 0.0001), liver weight-body weight ratio (P value < 0.0001), serum ALT levels (P value < 0.0001), serum AST (P value < 0.0017), serum total cholesterol (P value < 0.0001), serum triglycerides (P value < 0.0001), and serum LDL-cholesterol (P value < 0.0001). The extracts however showed no significant effects on HDL-cholesterol (P value = 0.4759).Histological analysis showed that the extract appears to possess protective effects against steatosis, inflammation and hepatic ballooning, with the high dose (400mg/kg) being more hepatoprotective. Conclusion:The freeze dried stem bark extract of Eryth...

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Hepatoprotective effects ofErythrina abyssinicaLam Ex Dc against Non Alcoholic Fatty Liver Disease in Sprague Dawley Rats

Yenesew

et al. 2019

Preprint

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“…Other plant species referred to for use in the treatment of trachoma include: Abrus precatorius L. [35], Calpurnia aurea [36], Dodonaea viscosa Linn. [37], Erythrina abyssinica [38], Erythrina indica [39], Jatropha curcas [40], Primula auriculata [41], and Tinospora smilacina Benth. [35].…”

Section: Ethnobotanical and Traditional Medicine As Drug Leadsmentioning

confidence: 99%

Natural Products for the Treatment of Trachoma and Chlamydia trachomatis

Potroz

Cho

2015

Molecules

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Abstract:The neglected tropical disease (NTD) trachoma is currently the leading cause of eye disease in the world, and the pathogenic bacteria causing this condition, Chlamydia trachomatis, is also the most common sexually transmitted pathogenic bacterium. Although the serovars of this bacterial species typically vary between ocular and genital infections there is a clear connection between genital C. trachomatis infections and the development of trachoma in infants, such that the solutions to these infections are closely related. It is the unique life cycle of the C. trachomatis bacteria which primarily leads to chronic infections and challenges in treatment using conventional antibiotics. This life cycle involves stages of infective elementary bodies (EBs) and reproductive reticulate bodies (RBs). Most antibiotics only target the reproductive RBs and this often leads to the need for prolonged therapy which facilitates the development of drug resistant pathogens. It is through combining several compounds to obtain multiple antimicrobial mechanisms that we are most likely to develop a reliable means to address all these issues. Traditional and ethnobotanical medicine provides valuable resources for the development of novel formulations and treatment regimes based on synergistic and multi-compound therapy. In this review we intend to summarize the existing literature on the application of natural compounds for controlling trachoma and inhibiting chlamydial bacteria and explore the potential for the development of new treatment modalities.

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“…Flavonoids, the main constituents present in many plant extracts, act as powerful free radical scavengers [17]. Many studies demonstrated positive correlation between antioxidant activity and phenolic content of plant extracts [18].…”

Section: Discusssionmentioning

confidence: 99%

Activity guided isolation of chemical constituents from the biologically active methanol extract of Euphorbia schimperi C. Presl

Ahmed¹,

e-Alam²,

Mothana³

et al. 2018

Bull. Chem. Soc. Eth.

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ABSTRACT. In this study we investigated the chemical constituents of bioactive methanol extract of Euphorbia schimperi C. Presl. For this the methanol extract was fractionated into 20, 40, 60, 80% MeOH in CHCl3, and 100% MeOH fractions respectively by vacuum liquid chromatography. Excision wound surface of the animals were topically treated with these fractions at a dose of 100 mg/kg body weight for twenty days. Povidone-iodine ointment was used as a reference drug. Wound contraction measurement and period of epithelialization were used to assess the effect of fractions on wound repairing. The 100% MeOH fraction treated animals achieved significant (p < 0.001) value by showing 100% wound contraction and minimum period of epithelization (17.75±0.47) on the 20 th day as compared to standard drug treated animals on the same day. The active 100% MeOH fraction was subjected to various chromatographic techniques led to the isolation of miquelianin (1), kaempferol 3-O-glucuronide (2) and quercitrin (3). Compounds (1-3) were isolated from this plant for the first time.

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8-Methoxyneorautenol and radical scavenging flavonoids from Erythrina abyssinica

Cited by 18 publications

References 12 publications

Hepatoprotective effects ofErythrina abyssinicaLam Ex Dc against Non Alcoholic Fatty Liver Disease in Sprague Dawley Rats

Hepatoprotective effects ofErythrina abyssinicaLam Ex Dc against Non Alcoholic Fatty Liver Disease in Sprague Dawley Rats

Natural Products for the Treatment of Trachoma and Chlamydia trachomatis

Activity guided isolation of chemical constituents from the biologically active methanol extract of Euphorbia schimperi C. Presl

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