8 Non-invasive methods for termination of second trimester pregnancy

Bygdeman, M.

doi:10.1016/s0950-3552(05)80231-7

Cited by 4 publications

(3 citation statements)

References 24 publications

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“…Prostaglandins and their analogues have become the predominant means of terminating second trimester pregnancy (Bygdeman 1990). Bowers et al (1989) have reported a series of 13 critically ill women in the late second trimester, six of whom had hypertensive or cardiac disorders.…”

Section: Discussionmentioning

confidence: 99%

Cardiogenic pulmonary oedema: presentation of pre‐eclampsia exacerbated by prostaglandin abortifacients

Levy

Hinshaw

Knox

et al. 1994

BJOG

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Section: Discussionmentioning

confidence: 99%

Cardiogenic pulmonary oedema: presentation of pre‐eclampsia exacerbated by prostaglandin abortifacients

Levy

Hinshaw

Knox

et al. 1994

BJOG

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“…The efficacy of RU 486 for cervical ripening and labor induction in the mid [3] or third [4,5] trimesters of pregnancy with live or dead fetuses has been reported [6]. We chose to associate RU 486 with prostaglandins in order to lower the doses of prostaglandins and minimize side effects [7], The combi nation of a laminaria tent with a prostaglandin E analogue has been reported to be effective in the midtrimester [7], Atienza et al [ 1 ] found only a modest effect on the course of abortion in cases of previous cesarean section when using a laminaria tent before amnioinfusions of prosta glandins. Our 13 % frequency of cesarean section for failed cervical dilatation reflects an excessive morbidity in comparison to that reported by Atienza et al [ 1 ].…”

Section: Discussionmentioning

confidence: 99%

Late Vaginal Induced Abortion after a Previous Cesarean Birth Potential for Uterine Rupture

Boulot

Hoffet

Bachelard

et al. 1993

Gynecol Obstet Invest

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This descriptive study was conducted to evaluate the risk of uterine rupture in cases of late vaginal induced abortions among women with previous cesarean sections. 23 women were referred at a mean gestational age of 23.9 (SD 6.9) weeks of gestation after one or two cesarean sections. Indications for terminating the pregnancy were maternal diseases in 4 cases and fetal anomalies in 19 cases. RU 486 and/or prostaglandins were used for cervical ripening and to induce labor. Vaginal birth was obtained in 20 cases (86.9%) with an average duration of 72 (SD 52) h. Cesarean section was performed in the remaining 3 women because no cervical dilation could be obtained. One uterine rupture occurred and was treated with conservation of the uterus. Late termination of pregnancy in such cases can be achieved without cesarean section with a high success rate.

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“…Prostaglandin E2 (PGE2) and its analogues have been used therapeutically for their stimulant actions on the pregnant human uterus for some 25 years (Bygdeman et al, 1968;Bygdeman, 1990). The work of Senior and colleagues (1993) clearly indicates that PGE analogues contract human myometrial smooth muscle by activating prostanoid EP3receptors.…”

Section: Introductionmentioning

confidence: 99%

Potent contractile actions of prostanoid EP₃‐receptor agonists on human isolated pulmonary artery

Qian

Jones

Chan

et al. 1994

British J Pharmacology

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1In 13 of 15 experiments, prostaglandin E2 (PGE2) and sulprostone (a prostanoid EPI/EP3-receptor agonist) contracted isolated rings of human pulmonary artery at low concentrations () 5 and > 0.5 nM respectively). Tissue was obtained from patients undergoing surgery mainly for carcinoma of the lung. Characterization of the receptors involved was complicated by loss of sensitivity to the contractile PGE action over the experimental period. In contrast, contractile responses to KCI, phenylephrine and the specific thromboxane (TP-) receptor agonist, U-46619, did not decrease with time. 2 The relative contractile potencies for seven PGE analogues, measured during the first few hours after setting up the preparations, were as follows: sulprostone > misoprostol = gemeprost > PGE2 > GR 63799X> 17-phenyl-w-trinor PGE2 1 1 1-deoxy PGE1. This ranking indicates that an EP3-receptor is involved. 3 The contractile action of sulprostone was not blocked by the TP-receptor antagonists, EP 169 and GR 32191, and the EPI-receptor antagonist, AH 6809.4 In two experiments, PGE2 (50 nM) reduced basal tone and sulprostone was a weak contractile agent.Phenylephrine-induced tone was also inhibited by PGE2 (EC50 = 5-20 nM), 1 1-deoxy PGEI and butaprost (a selective EP2-receptor agonist); the latter prostanoids were about 2 and 4 times less potent than PGE2 respectively. Interactions with phenylephrine were different in experiments where PGE2 alone was contractile: PGE2 induced contraction superimposed on the phenylephrine response and 11-deoxy PGE, induced either further contraction or had no effect. Butaprost produced relaxation at high concentrations; this may not be an EP2 action since preparations were highly sensitive to relaxant actions of prostacyclin (IP-) receptor agonists (cicaprost and TEI-9063). 5 The study has shown that in the majority of experiments on the human isolated pulmonary artery, the contractile EP3 system outweighed the relaxant EP2 system. However, in two experiments the reverse was true. It is not clear to what extent these differences are due to disease processes affecting the tissues. The findings are discussed in relation to the adverse cardiovascular responses occasionally encountered during treatment of postpartum haemorrhage with sulprostone, and more generally to the clinical use of EP-receptor agonists in man.

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8 Non-invasive methods for termination of second trimester pregnancy

Cited by 4 publications

References 24 publications

Cardiogenic pulmonary oedema: presentation of pre‐eclampsia exacerbated by prostaglandin abortifacients

Cardiogenic pulmonary oedema: presentation of pre‐eclampsia exacerbated by prostaglandin abortifacients

Late Vaginal Induced Abortion after a Previous Cesarean Birth Potential for Uterine Rupture

Potent contractile actions of prostanoid EP₃‐receptor agonists on human isolated pulmonary artery

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8 Non-invasive methods for termination of second trimester pregnancy

Cited by 4 publications

References 24 publications

Cardiogenic pulmonary oedema: presentation of pre‐eclampsia exacerbated by prostaglandin abortifacients

Cardiogenic pulmonary oedema: presentation of pre‐eclampsia exacerbated by prostaglandin abortifacients

Late Vaginal Induced Abortion after a Previous Cesarean Birth Potential for Uterine Rupture

Potent contractile actions of prostanoid EP3‐receptor agonists on human isolated pulmonary artery

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Product

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Potent contractile actions of prostanoid EP₃‐receptor agonists on human isolated pulmonary artery