Titanium dioxide (TiO2 ) is a widely studied material and exists in three major crystal structures: rutile, brookite and anatase. Due to its advantages in high chemical and thermal stability, non-toxicity, high catalytic activity, resistance to corrosion, and high reactivity under ultraviolet light (<387 nm),it can be used in many applications such as photo catalysis, photovoltaics, sensors, hydrogen generators batteries, self-cleaning, electrochromic devices and also used in some biomedical application for site specific drug delivery . These applications in various fields depends not only on the properties of the TiO2 material but also it involves in modifying TiO2 structure and doping of other element on it which will show adverse impact in application of TiO2 with the surrounding environment. In this review, we are discussing about the synthesis, properties, and applications of titanium dioxide nanoparticle (TiO2 NP) in various fields.