824 WHITE BLOOD CELL CHANGES &amp; INCIDENCE OF FEVER AFTER MATERNAL TREATMENT WITH GLUCOCORTICOIDS

Wong, Yuk-Cheung; Taeusch, H W

doi:10.1203/00006450-197804001-00829

Cited by 7 publications

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“…. androgens and estrogens have a limited affinity Following steroid injection a transient increase ^ Ofs j[ dditionally> the mat ernalm WBC count has been observed m mothers ^> * ^ ^ § b ut not in their infants [68]. However, we have ^ factor ^ ch^ ^ ^ of observed some rare leukemoid reactions in a…”

Section: Steroids and Immunitymentioning

confidence: 70%

Review article

1986

Journal of Perinatal Medicine

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Section: Steroids and Immunitymentioning

confidence: 70%

Review article

1986

Journal of Perinatal Medicine

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“…Since then dexamethasone (DEX) has been used in similar antepartum therapy studies which confirmed acceleration of fetal lung mat uration [Caspi et al, 1976[Caspi et al, , 1980. The observation of acute and chronic side effects associated with synthetic glucocorticoid administration to humans or animal models [Wong and Taeusch, 1978;Reinisch et al. 1978;Carson et al, 1973;Gandelman and Guerriero, 1982] coupled with the fact that in some instances RDS developed in spite of glucocorticoid therapy [Caspi et al, 1980] has provoked concern regarding the use of these drugs for RDS treatment.…”

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confidence: 99%

Transplacental Metabolism of Dexamethasone and Cortisol in the Late Gestational Age Rhesus Monkey (Macaca mulatta)

Althaus¹,

Bailey²,

Leakey³

et al. 1986

Dev Pharmacol Ther

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The synthetic glucocorticoid dexamethasone (DEX) and endogenous cortisol were compared in 2 groups of pregnant monkeys of gestational age 143-148 days. In group I, a fetal intraplacental vein and a maternal femoral vessel were catheterized. 3H- Cortisol and 14C-DEX were administered intravenously along with 0.2 mg/kg unlabelled DEX to the mother. Blood and tissue samples were collected to 3 h and urine and feces to 96 h. In group II, 4 of the 7 animals were predosed with DEX 10 mg/kg s.c. for 3 days prior to surgery. The fetus was removed by cesarean section and the in situ placenta was perfused via the umbilical arteries at 15 ml/min X 8 min with 3H-cortisol/14C-DEX in Hanks’ balanced salt solution. Samples were taken from the umbilical vein and uterine vein. In group I, HPLC analysis of paired maternal and fetal plasma samples taken at 10, 20. 60. 120 and 180 min after dosing indicated that the F/M DEX ratio was significantly greater than the F/M cortisol ratio. In fetal lung and liver tissues analyzed, less than 2% of the cortisol remained unmetabolized by 3 h, whereas ≥ 76% DEX remained as parent compound. There was no significant difference between the percentage of DEX (83 ± 7%) and cortisol (73 ± 3%) recovery in maternal urine and feces. In group II, HPLC analysis of paired umbilical vein and uterine vein samples at 2, 4 and 8 min showed that by 8 min 24% of cortisol was converted to cortisone by the uteroplacenta, but only 2.5% of DEX was converted to a metabolite. In DEX-pretreated animals both uterine vein and umbilical vein samples indicated an increase in cortisol to cortisone conversion. A significant increase in DEX metabolism was evident in the uterine vein samples but not the umbilical vein. These data indicate that the fetus is exposed to a higher proportion of DEX than cortisol and that the uteroplacenta plays a larger role in cortisol than in DEX metabolism. In addition, these data suggest that DEX pretreatment enhances the ability of the uteroplacenta to convert cortisol to cortisone.

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Antenatal Glucocorticoid Therapy: Clinical Effects

Ballard¹

1986

Hormones and Lung Maturation

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824 WHITE BLOOD CELL CHANGES & INCIDENCE OF FEVER AFTER MATERNAL TREATMENT WITH GLUCOCORTICOIDS

Cited by 7 publications

References 0 publications

Review article

Review article

Transplacental Metabolism of Dexamethasone and Cortisol in the Late Gestational Age Rhesus Monkey (Macaca mulatta)

Antenatal Glucocorticoid Therapy: Clinical Effects

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