Untitled

Nabi, Ghulam

doi:10.1023/a:1021315130481

Cited by 15 publications

(5 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…CDC is located in the renal medulla and originates from the epithelial cells of Bellini collecting ducts [1]. Because of its unique biological and pathologic characteristics that are different from the other renal cell carcinomas, it’s considered to be an independent histological type.…”

Section: Discussionmentioning

confidence: 99%

“…Collecting duct carcinoma (CDC) is a type of kidney cancer that originates in the duct of Bellini of the kidney and also known by several synonyms like Bellini duct carcinoma, medullary renal carcinoma, distal renal tubular carcinoma and distal nephron carcinoma [1,2]. CDC is an unusual variant of renal cell carcinoma and accounts for about 1% of all renal cell carcinomas.…”

Section: Introductionmentioning

confidence: 99%

“…CDC is an unusual variant of renal cell carcinoma and accounts for about 1% of all renal cell carcinomas. CDC is differentiated from other renal cell carcinomas by its characteristic location, typical histological appearance and poor prognosis [1]. CDC metastasizes to regional lymph nodes in approximately 80% of cases, to the lung or adrenal gland in 25% and to the liver in 20% [3].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

RETRACTED ARTICLE: Collecting duct carcinoma of the kidney: a clinicopathological study of five cases

et al. 2013

View full text Add to dashboard Cite

ObjectiveTo investigate the clinicopathological features of collecting duct carcinoma (CDC) and improve its diagnosis and treatment.MethodsA retrospective analysis was performed with clinical data including follow-up results of five patients with CDC.ResultsA total of 5 cases, including 4 males and 1 female, were included in this analysis with the average age 54 years (range 42 to 65). Patients mainly suffered from lumbar pain, hematuria, abdominal mass and low grade fever. Four patients underwent radical nephrectomy while another received palliative nephrectomy. Lymph node metastasis occurred in 3 cases and renal hilum fat metastasis happened to 2 other cases. Tumors was located in the renal medulla and presented invasive growth. They had a tubulopapillary architecture with the hobnail-shaped cells protruding into the glandular lumen, and were accompanied by interstitial fibrosis and dysplasia of epithelial cells in collecting ducts adjacent to the tumors. One tumor was staged at AJCC II, two at AJCC III and two at AJCC IV. Postoperative interferon immunotherapy was applied in 2 cases. Patients were followed up for 5 to 18 months and the average survival time was 10 months.ConclusionThe CDC exhibits special clinicopathological features, high degree of malignancy and poor prognosis. The diagnosis depends on the histopathological examination. Early detection and early surgical treatment are still the main methods to improve the prognosis of patients with CDC.Virtual SlidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/3702794279387989

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

RETRACTED ARTICLE: Collecting duct carcinoma of the kidney: a clinicopathological study of five cases

et al. 2013

View full text Add to dashboard Cite

show abstract

“…The prognostic relevance was determined by establishing a disease-specific risk model that considered tumor size, metastasis, grade, and lymph vessel infiltration [8]. To date, no reports have documented that patients with localized CDC who are treated by nephron-sparing renal surgery or radical nephrectomy have favorable outcomes and that as a result, surgery could be a curative treatment option [21,22]. Unfortunately, the number of localized CDCs in the present study is small (n=7), and the mean follow-up is rather short (28.3 months), but a 100% CSS of two patients after five years has been calculated.…”

Section: Discussionmentioning

confidence: 99%

Collecting Duct Carcinomas Represent a Unique Tumor Entity Based on Genetic Alterations

et al. 2013

View full text Add to dashboard Cite

Collecting duct carcinoma (CDC) is a rare renal neoplasm that is associated with poor prognosis due to its highly aggressive course and limited response to immuno- or chemotherapy. Histologically, CDC is defined as a subtype of renal cell carcinomas, but in some cases, it is difficult to differentiate from urothelial carcinomas (UC). Therefore the aim of this study was to determine genetic alterations of CDC in comparison to that of urothelial carcinomas of the upper urinary tract (UUT-UC) to clarify the histological origin of this rare tumor entity. Twenty-nine CDC samples were obtained from seven different German centers and compared with twenty-six urothelial carcinomas of the upper urinary tract. Comparative genomic hybridization (CGH) was used to investigate the genetic composition of patients’ tumors and allowed the detection of losses and gains of DNA copy numbers throughout the entire genome. The clinical data were correlated with CGH results. CGH analysis of CDC revealed DNA aberrations in many chromosomes. DNA losses were more frequently observed than gains, while high-level amplifications were not detected. The mean frequency of CDC chromosomal aberrations (4.9/case) was slightly lower than that in UUT-UC (5.4/case). Recurrent CDC DNA losses occurred at 8p (n=9/29), 16p (9/29), 1p (n=7/29) and 9p (n=7/29), and gains occurred in 13q (n=9/29). In contrast to CDC, the most frequently detected UUT-UC DNA aberration was a loss at 9q (n=13/26). DNA losses at 9q, 13q and 8q as well as gains at 8p showed significant variations in UUT-UC compared to CDC. There was no correlation between the patients’ clinical course and the presence or absence of these recurrent genetic alterations. CDCs are characterized by a different genetic pattern compared to UUT-UC. Regarding the published data on renal cell carcinoma, we conclude that CDC appears to be a unique entity among kidney carcinomas.

show abstract

“…На сегодняшний день в литературе описано около 400 случаев карциномы протоков Bellini [9]. Таким образом, из-за редкости данного заболевания и недостаточной клинической осведомленности установленного протокола диагностики и лечения не существует [11]. С целью расширения представлений и систематизации имеющейся информации мы описали наше клиническое наблюдение пациента с обнаруженной на ранней стадии карциномой протоков Bellini, а также провели литературный обзор, посвящённый данному подтипу ПКР.…”

Section: Introductionunclassified

Collecting duct (Bellini duct) renal cell carcinoma: a clinical case and literature review

Sorokin,

Sinitsyn,

Kharlova

et al. 2024

Vestn. Urol.

View full text Add to dashboard Cite

A rare subtype of renal cell carcinoma (RCC) is Bellini collecting duct carcinoma, also known as medullary renal carcinoma or distal nephron carcinoma, which accounts for 0.4-2.0% of all RCC cases. This subtype has the poorest prognosis of all RCC subtypes, typically presenting as a low-grade tumor at the pT3 or higher stage. Consequently, many patients have distant metastases at diagnosis and 60% develop metastases following radical treatment. There have been approximately 400 literature-reported cases of Bellini ductal carcinoma to date. We present a case report of a patient with early-stage Bellini duct cancer and a literature review of published reports on this condition.

show abstract

Untitled

Abstract: 40 worldwide reported cases of Bellini duct carcinoma were found. We analyzed their salient pathological, diagnostic and management strategies. A simplistic approach and a clinical algorithm has been suggested to enable their rapid identification, diagnosis and management.

Cited by 15 publications

References 20 publications

RETRACTED ARTICLE: Collecting duct carcinoma of the kidney: a clinicopathological study of five cases

RETRACTED ARTICLE: Collecting duct carcinoma of the kidney: a clinicopathological study of five cases

Collecting Duct Carcinomas Represent a Unique Tumor Entity Based on Genetic Alterations

Collecting duct (Bellini duct) renal cell carcinoma: a clinical case and literature review

Contact Info

Product

Resources

About