883 Urinary Levels of Brain Derived Neurotrophic Factor (Bdnf) in Women With Overactive Bladder (Oab) Syndrome Correlate With the Severity of Symptoms

Antunes-Lopes, Tiago; Pinto, Rui; Carvalho-Barros, Sérgio; Diniz, Paulo; Martins-Silva, Carlos; Cruz, Célia Duarte; Cruz, Francisco

doi:10.1016/s1569-9056(11)60867-1

Cited by 15 publications

(10 citation statements)

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“…A number of urinary and imaging biomarkers, including urinary nerve growth factor, urinary brain-derived neurotrophic factor, urinary prostaglandin E2, bladder wall thickness, and estimated bladder weight, have been shown to be associated with LUTD status [6][7][8]. Nonetheless, their diagnostic role in clinical practice remains to be determined because of lack of specificity for LUTD subtypes and lack of reproducibility [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

The role of serum C-reactive protein in women with lower urinary tract symptoms

2012

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Section: Introductionmentioning

confidence: 99%

The role of serum C-reactive protein in women with lower urinary tract symptoms

2012

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“…Another clinical study proved that BDNF/creatinine decreased as a result of treatment with cholinergic blocking agents. What is particularly interesting is that the drop in BDNF/creatinine correlated with a decrease in urinary urgency, which was not observed in the case of NGF/creatinine [3].…”

Section: Bdnfmentioning

confidence: 90%

Novel biomarkers of overactive bladder syndrome

et al. 2017

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The social aspect of overactive bladder syndrome (OAB) and the lack of objective diagnostic methods for this syndrome have spurred research into its potential biomarkers which can constitute useful diagnostic tools, while also allowing the evaluation of the intensity of clinical symptoms and the efficacy of implemented pharmacotherapy in OAB patients. Due to the complex etiopathogenesis of this syndrome, the researchers are seeking biomarkers connected with inflammation or nerve growth. The aim of this review was to analyse the latest literature data regarding potential biomarkers in OAB. The most promising opportunities are connected with the diagnostic use of the nerve growth factor (NGF), the brain derived neurotrophic factor (BDNF), C-reactive protein (CRP), prostaglandins and cytokines. Despite the most promising results to date having been obtained with regards to neurotrophic factors, it seems that, at the moment, none of these meets the criteria for becoming an isolated OAB marker. It is also suggested that the combined use of several biomarkers will facilitate obtaining the appropriate level of specificity and selectivity to allow their use in clinical practice.

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“…На моделях животных показана ключевая роль МНФ в формировании гиперчувствитель-ности детрузора при циститах [40,41].…”

Section: мочевые биомаркерыunclassified

“…На фоне терапии концентрация МНФ в моче значительно уменьшалась до нормы, что позволяет рассматривать МНФ как потенциальный биомаркер ГМП [41,42]. Не-обходимо проведение дальнейших крупных исследова-ний.…”

Section: мочевые биомаркерыunclassified

Novelty in the diagnosis of overactive bladder

Amirova¹,

Балан²,

Kovaleva³

et al. 2015

Ross. vestn. akush.-ginekol.

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Увеличение продолжительности жизни населения влечет за собой повышение частоты развития заболева-ний, ассоциированных с возрастом, в том числе гиперак-тивного мочевого пузыря (ГМП). По данным последних эпидемиологических исследований, распространенность симптомов ГМП составляет 7-27% среди мужчин и 9-43% среди женщин [1].Показано, что частота развития ГМП у женщин со-ставляет 20-30% в репродуктивном возрасте, 30-40% в перименопаузе и ранней постменопаузе, а в пожилом воз-расте достигает 50%. Установлено, что пациенты редко обращаются за медицинской помощью, а среди обратив-шихся только 2% получают адекватную терапию [2]. «Золотым стандартом» в диагностике ГМП и гипер-активности детрузора является комплексное уродинами-ческое исследование, однако инвазивность, трудоем-кость и дороговизна метода зачастую являются прегра-дой для масштабного скрининга населения с целью улуч-шения качества доступной медицинской помощи. Со-временные исследования посвящены определению воз-можностей использования неинвазивных биомаркеров для выявления симптомов ГМП, оценки эффективности лечения и прогнозирования исхода заболевания. Подоб-ные методики включают ультразвуковую оценку толщи-ны стенки мочевого пузыря и толщины детрузора, опре-деление параметров сывороточных (С-реактивный бе-

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883 Urinary Levels of Brain Derived Neurotrophic Factor (Bdnf) in Women With Overactive Bladder (Oab) Syndrome Correlate With the Severity of Symptoms

Cited by 15 publications

References 0 publications

The role of serum C-reactive protein in women with lower urinary tract symptoms

The role of serum C-reactive protein in women with lower urinary tract symptoms

Novel biomarkers of overactive bladder syndrome

Novelty in the diagnosis of overactive bladder

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