9.4T Magnetic Resonance Imaging of the Mouse Circle of Willis Enables Serial Characterization of Flow-Induced Vascular Remodeling by Computational Fluid Dynamics

Tutino, Vincent M.; Rajabzadeh-Oghaz, Hamidreza; Chandra, Anusha Ramesh; Gutierrez, Liza; Schweser, Ferdinand; Preda, Marilena; Chien, Aichi; Vakharia, Kunal; Ionita, Ciprian N.; Siddiqui, Adnan H.; Kolega, John

doi:10.2174/1567202616666181127165943

Cited by 8 publications

(14 citation statements)

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“…Taking into account that several morphologic variations of the ACoA were described in humans, [ 94 ] and that atherosclerotic stenosis of the ICA can trigger flow increase in the ACoA and possibly precipitate flow‐induced vessel remodeling, [ 28,80,81 ] we suggest that certain anatomical configurations and/or altered hemodynamic conditions of the ACoA could lead to suboptimal functioning of the forebrain sensory CVO.…”

Section: Acoa Is a Special Vascular Niche That Facilitates Sensoric Fmentioning

confidence: 92%

“…[ 12,28,29 ] Atherosclerotic stenosis is a slow progressing pathologic process which theoretically gives blood vessels enough time to adapt to an increased flow and remodel accordingly. [ 26,79–81 ] Endothelial mechanoceptors transduce the perceived increase in blood flow into intracellular signaling. [ 80,82,83 ] This triggers reorganization of adhesion proteins in the basement membrane.…”

Section: Acoa Does Not Contribute To Cerebral Circulation Under Physimentioning

confidence: 99%

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The circle of Willis revisited: Forebrain dehydration sensing facilitated by the anterior communicating artery

et al. 2020

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We hypothesize that threat of dehydration provided selection pressure for the evolutionary emergence and persistence of the anterior communicating artery (ACoA – the inter‐arterial connection that completes the Circle of Willis) in early amniotes. The ACoA is a hemodynamically insignificant artery, but, as we argue in this paper, its privileged position outside the blood‐brain barrier gives it a crucial sensing function for the osmolarity of the blood against the background of the rest of the brain, which efficiently protects itself from dehydration. Till now, the questions of why the ACoA evolved, and what its physiological function is, have remained unsatisfactorily answered. The traditional view—that the ACoA serves as a collateral source of vascularization in case of arterial stenosis—is anthropocentric, and not in accordance with principles of natural selection that apply more generally. Diseases underlying arterial stenosis are associated with aging and the human lifestyle, so this cannot explain why the ACoA formed hundreds of millions of years ago and persisted in amniotes to this day. The peculiar hemodynamic properties of the ACoA could be selected traits that allowed for more efficient forebrain detection of dehydration and complex behavioral responses to water loss, a major advantage in the survival of early amniotes. This hypothesis also explains insufficient hydration often seen in elderly humans.

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Section: Acoa Is a Special Vascular Niche That Facilitates Sensoric Fmentioning

confidence: 92%

Section: Acoa Does Not Contribute To Cerebral Circulation Under Physimentioning

confidence: 99%

The circle of Willis revisited: Forebrain dehydration sensing facilitated by the anterior communicating artery

et al. 2020

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“…[ 155 ] 2017 X Surgical Rabbits Saccular X Tutino V.M. [ 156 ] 2018 X Endogenous Mice Saccular X X Greim-Kuczewski K. [ 157 ] 2018 X Surgical Rabbits Saccular X Marotta T.R. [ 158 ] 2018 X Surgical Rabbits Saccular X Li Z.F.…”

Section: Methodsmentioning

confidence: 99%

Imaging of intracranial aneurysms in animals: a systematic review of modalities

et al. 2023

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Intracranial aneurysm (IA) animal models are paramount to study IA pathophysiology and to test new endovascular treatments. A number of in vivo imaging modalities are available to characterize IAs at different stages of development in these animal models. This review describes existing in vivo imaging techniques used so far to visualize IAs in animal models. We systematically searched for studies containing in vivo imaging of induced IAs in animal models in PubMed and SPIE Digital library databases between 1 January 1945 and 13 July 2022. A total of 170 studies were retrieved and reviewed in detail, and information on the IA animal model, the objective of the study, and the imaging modality used was collected. A variety of methods to surgically construct or endogenously induce IAs in animals were identified, and 88% of the reviewed studies used surgical methods. The large majority of IA imaging in animals was performed for 4 reasons: basic research for IA models, testing of new IA treatment modalities, research on IA in vivo imaging of IAs, and research on IA pathophysiology. Six different imaging techniques were identified: conventional catheter angiography, computed tomography angiography, magnetic resonance angiography, hemodynamic imaging, optical coherence tomography, and fluorescence imaging. This review presents and discusses the advantages and disadvantages of all in vivo IA imaging techniques used in animal models to help future IA studies finding the most appropriate IA imaging modality and animal model to answer their research question.

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“…In fact, only a few studies use them other than as IA detection tools, for instance to detect macrophage infiltration or to perform CFD analysis on 3DRA images ( 77 , 99 ). To the best of our knowledge, only 2 studies managed to follow aneurysmal remodeling in mice over 3 months using really high-field MRI (9,4T) ( 100 , 101 ). Regarding IA's hemodynamics, Doppler ultrasound imaging can be used to measure blood flow velocity in rabbit models of internal carotid aneurysm ( 99 , 102 , 103 ).…”

Section: Inflammation Imagingmentioning

confidence: 99%

Imaging Modalities for Intracranial Aneurysm: More Than Meets the Eye

Maupu

Lebas

Boulaftali

2022

Front. Cardiovasc. Med.

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Intracranial aneurysms (IA) are often asymptomatic and have a prevalence of 3 to 5% in the adult population. The risk of IA rupture is low, however when it occurs half of the patients dies from subarachnoid hemorrhage (SAH). To avoid this fatal evolution, the main treatment is an invasive surgical procedure, which is considered to be at high risk of rupture. This risk score of IA rupture is evaluated mainly according to its size and location. Therefore, angiography and anatomic imaging of the intracranial aneurysm are crucial for its diagnosis. Moreover, it has become obvious in recent years that several other factors are implied in this complication, such as the blood flow complexity or inflammation. These recent findings lead to the development of new IA imaging tools such as vessel wall imaging, 4D-MRI, or molecular MRI to visualize inflammation at the site of IA in human and animal models. In this review, we will summarize IA imaging techniques used for the patients and those currently in development.

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9.4T Magnetic Resonance Imaging of the Mouse Circle of Willis Enables Serial Characterization of Flow-Induced Vascular Remodeling by Computational Fluid Dynamics

Cited by 8 publications

References 0 publications

The circle of Willis revisited: Forebrain dehydration sensing facilitated by the anterior communicating artery

The circle of Willis revisited: Forebrain dehydration sensing facilitated by the anterior communicating artery

Imaging of intracranial aneurysms in animals: a systematic review of modalities

Imaging Modalities for Intracranial Aneurysm: More Than Meets the Eye

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