∆9‑tetrahydrocannabinol inhibits epithelial‑mesenchymal transition and metastasis by targeting matrix metalloproteinase‑9 in endometrial cancer

Zhang, Yingzhi; Wei, Zheng; Shen, Kewei; Sui, Weiwei

doi:10.3892/ol.2018.8407

Cited by 21 publications

(15 citation statements)

References 32 publications

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“…NF-κβ is one of the key regulators of inflammation and tumor metastasis, survival, invasion, angiogenesis, and chemoresistance [ 86 ]. Cannabinoids also curtail tumor invasion and metastasis by inhibiting the secretion of matrix metalloproteinase (MMP)-2 [ 84 , 87 ] and MMP-9 [ 84 , 88 ], while increasing the tissue inhibitors of MMP-1 (TIMP-1) [ 89 ]. THC induces autophagy-mediated cell death as a result of stimulating the p8-regulated pathway.…”

Section: Discussionmentioning

confidence: 99%

Cannabinoid Combination Induces Cytoplasmic Vacuolation in MCF-7 Breast Cancer Cells

2020

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This study evaluated the synergistic anti-cancer potential of cannabinoid combinations across the MDA-MB-231 and MCF-7 human breast cancer cell lines. Cannabinoids were combined and their synergistic interactions were evaluated using median effect analysis. The most promising cannabinoid combination (C6) consisted of tetrahydrocannabinol, cannabigerol (CBG), cannabinol (CBN), and cannabidiol (CBD), and displayed favorable dose reduction indices and limited cytotoxicity against the non-cancerous breast cell line, MCF-10A. C6 exerted its effects in the MCF-7 cell line by inducing cell cycle arrest in the G2 phase, followed by the induction of apoptosis. Morphological observations indicated the induction of cytoplasmic vacuolation, with further investigation suggesting that the vacuole membrane was derived from the endoplasmic reticulum. In addition, lipid accumulation, increased lysosome size, and significant increases in the endoplasmic reticulum chaperone protein glucose-regulated protein 78 (GRP78) expression were also observed. The selectivity and ability of cannabinoids to halt cancer cell proliferation via pathways resembling apoptosis, autophagy, and paraptosis shows promise for cannabinoid use in standardized breast cancer treatment.

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Section: Discussionmentioning

confidence: 99%

Cannabinoid Combination Induces Cytoplasmic Vacuolation in MCF-7 Breast Cancer Cells

2020

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“…There are currently very limited options for treatment of aggressive endometrial cancer, and it has been shown that cannabinoid receptors are highly expressed in endometrial cancer tissues. THC treatment of endometrial cancer cells decreased cell viability and motility as a result of inhibiting the epithelial-mesenchymal transition and decreasing metalloproteinase-9 gene expression [132]. ATP-binding cassette (ABC) transporters are highly implicated in the resistance of cancers to anti-cancer drugs.…”

Section: Endometrial and Cervical Cancersmentioning

confidence: 99%

Anti-Cancer Potential of Cannabinoids, Terpenes, and Flavonoids Present in Cannabis

Tomko

Whynot

Ellis

et al. 2020

Cancers

162

139

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In recent years, and even more since its legalization in several jurisdictions, cannabis and the endocannabinoid system have received an increasing amount of interest related to their potential exploitation in clinical settings. Cannabinoids have been suggested and shown to be effective in the treatment of various conditions. In cancer, the endocannabinoid system is altered in numerous types of tumours and can relate to cancer prognosis and disease outcome. Additionally, cannabinoids display anticancer effects in several models by suppressing the proliferation, migration and/or invasion of cancer cells, as well as tumour angiogenesis. However, the therapeutic use of cannabinoids is currently limited to the treatment of symptoms and pain associated with chemotherapy, while their potential use as cytotoxic drugs in chemotherapy still requires validation in patients. Along with cannabinoids, cannabis contains several other compounds that have also been shown to exert anti-tumorigenic actions. The potential anti-cancer effects of cannabinoids, terpenes and flavonoids, present in cannabis, are explored in this literature review.

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“…They found that THC inhibited endometrial cancer cell proliferation and migration by a decreased expression of matrix metalloproteinase-9 but not matrix metalloproteinase-2. The same effects could be detected after matrix metalloproteinase-9 silencing [116]. More recently, the involvement of THC and CBD in endometrial cancer was investigated in 2 model cell lines, i.e., Ishikawa and Hec50co cells [117].…”

Section: The Ecs In Gynecological Disorders and Cancermentioning

confidence: 82%

“…The effects of pCB, such as THC, on endometrial cancer progression was recently evaluated by Zhang et al [116]. They found that THC inhibited endometrial cancer cell proliferation and migration by a decreased expression of matrix metalloproteinase-9 but not matrix metalloproteinase-2.…”

Section: The Ecs In Gynecological Disorders and Cancermentioning

confidence: 99%

Cannabinoids in Gynecological Diseases

Luschnig

Schicho

2019

Med Cannabis Cannabinoids

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The endocannabinoid system (ECS) is a multifunctional homeostatic system involved in many physiological and pathological conditions. The ligands of the ECS are the endocannabinoids, whose actions are mimicked by exogenous cannabinoids, such as phytocannabinoids and synthetic cannabinoids. Responses to the ligands of the ECS are mediated by numerous receptors like the classical cannabinoid receptors (CB1 and CB2) as well as ECS-related receptors, e.g., G protein-coupled receptors 18 and 55 (GPR18 and GPR55), transient receptor potential ion channels, and nuclear peroxisome proliferator-activated receptors. The ECS regulates almost all levels of female reproduction, starting with oocyte production through to parturition. Dysregulation of the ECS is associated with the development of gynecological disorders from fertility disorders to cancer. Cannabinoids that act at the ECS as specific agonists or antagonists may potentially influence dysregulation and, therefore, represent new therapeutic options for the therapy of gynecological disorders.

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∆9‑tetrahydrocannabinol inhibits epithelial‑mesenchymal transition and metastasis by targeting matrix metalloproteinase‑9 in endometrial cancer

Cited by 21 publications

References 32 publications

Cannabinoid Combination Induces Cytoplasmic Vacuolation in MCF-7 Breast Cancer Cells

Cannabinoid Combination Induces Cytoplasmic Vacuolation in MCF-7 Breast Cancer Cells

Anti-Cancer Potential of Cannabinoids, Terpenes, and Flavonoids Present in Cannabis

Cannabinoids in Gynecological Diseases

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