90Y bremsstrahlung emission computed tomography using gamma cameras

Ito, Shigeki; Kurosawa, Hiroyuki; Kasahara, Hiroyuki; Teraoka, Satomi; Ariga, Eiji; Deji, Shizuhiko; Hirota, Mitsutomo; Saze, Takuya; Minamizawa, Takao; Nishizawa, Kunihide

doi:10.1007/s12149-009-0233-9

Cited by 33 publications

(22 citation statements)

References 16 publications

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“…The rise in the spectrum of about 150 keV reflects the penetration of the septa of the collimators by higher energy. The same phenomenon has been previously reported in 32 P, 90 Y, and 89 Sr BS measurements with a gamma camera [9–11, 13, 15, 27]. Although the maximum energies of 32 P and 90 Y are different (1.7 MeV vs. 2.27 MeV), their BS spectra appear to be similar.…”

Section: Discussionsupporting

confidence: 85%

Technical Considerations of Phosphorous-32 Bremsstrahlung SPECT Imaging after Radioembolization of Hepatic Tumors: A Clinical Assessment with a Review of Imaging Parameters

Pirayesh

Amoui

Akhlaghpoor

et al. 2014

Radiology Research and Practice

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Background. Bremsstrahlung (BS) imaging during radioembolization (RE) confirms the deposition of radiotracer in hepatic/extrahepatic tumors. The aim of this study is to demonstrate 32P images and to optimize the imaging parameters. Materials and Methods. Thirty-nine patients with variable types of hepatic tumors, treated with the intra-arterial injection of 32P, were included. All patients underwent BS SPECT imaging 24–72 h after tracer administration, using low energy high resolution (LEHR) (18 patients) or medium energy general purpose (MEGP) (21 patients) collimators. A grading scale from 1 to 4 was used to express the compatibility of the 32P images with those obtained from CT/MRI. Results. Although the image quality obtained with the MEGP collimator was visually and quantitatively better than with the LEHR (76% concordance score versus 71%, resp.), there was no statistically significant difference between them. Conclusion. The MEGP collimator is the first choice for BS SPECT imaging. However, if the collimator change is time consuming (as in a busy center) or an MEGP collimator is not available, the LEHR collimator could be practical with acceptable images, especially in a SPECT study. In addition, BS imaging is a useful method to confirm the proper distribution of radiotherapeutic agents and has good correlation with anatomical findings.

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Section: Discussionsupporting

confidence: 85%

Technical Considerations of Phosphorous-32 Bremsstrahlung SPECT Imaging after Radioembolization of Hepatic Tumors: A Clinical Assessment with a Review of Imaging Parameters

Pirayesh

Amoui

Akhlaghpoor

et al. 2014

Radiology Research and Practice

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“…Medium-energy (MEGP) and high-energy general purpose (HEGP) collimators were mounted for the 90 Y and 166 Ho measurements, to reduce collimator penetration of high-energy photons. The energy window settings for 90 Y Bremsstrahlung imaging vary between institutions, ranging from small windows with a relatively low central energy [23], [24], to intermediate [5], [6] and broad energy windows [4], [7], [25]–[27]. Although it is generally believed that a wide energy window is required to maintain sufficient sensitivity, no consensus exists on the optimal central energy and window width.…”

Section: Methodsmentioning

confidence: 99%

Quantitative Evaluation of Scintillation Camera Imaging Characteristics of Isotopes Used in Liver Radioembolization

et al. 2011

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BackgroundScintillation camera imaging is used for treatment planning and post-treatment dosimetry in liver radioembolization (RE). In yttrium-90 (90Y) RE, scintigraphic images of technetium-99m (99mTc) are used for treatment planning, while 90Y Bremsstrahlung images are used for post-treatment dosimetry. In holmium-166 (166Ho) RE, scintigraphic images of 166Ho can be used for both treatment planning and post-treatment dosimetry. The aim of this study is to quantitatively evaluate and compare the imaging characteristics of these three isotopes, in order that imaging protocols can be optimized and RE studies with varying isotopes can be compared.Methodology/Principal FindingsPhantom experiments were performed in line with NEMA guidelines to assess the spatial resolution, sensitivity, count rate linearity, and contrast recovery of 99mTc, 90Y and 166Ho. In addition, Monte Carlo simulations were performed to obtain detailed information about the history of detected photons. The results showed that the use of a broad energy window and the high-energy collimator gave optimal combination of sensitivity, spatial resolution, and primary photon fraction for 90Y Bremsstrahlung imaging, although differences with the medium-energy collimator were small. For 166Ho, the high-energy collimator also slightly outperformed the medium-energy collimator. In comparison with 99mTc, the image quality of both 90Y and 166Ho is degraded by a lower spatial resolution, a lower sensitivity, and larger scatter and collimator penetration fractions.Conclusions/SignificanceThe quantitative evaluation of the scintillation camera characteristics presented in this study helps to optimize acquisition parameters and supports future analysis of clinical comparisons between RE studies.

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“…Later, the same group proved that this image could be quantified and thus be useful for post SIRT dosimetry [57]. With our scanner (General Electric; Discovery D690) we consider that for the amount of Sirsphere (1-3 GBq) injected, each bed position acquisition must at least last 30 minutes in order to obtain acceptable results ( Figure 11).…”

Section: Y Positron Emission Tomographymentioning

confidence: 99%

New Imaging Techniques for 90Y Microsphere Radioembolization

Vouche¹,

Vanderlinden²,

Delatte³

et al. 2011

J Nucl Med Radiat Ther

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Adequate patient selection and treatment planning is crucial for a safe and cost-effective administration of selective internal radiotherapy (SIRT) of malignant liver disease using 90 Y-labelled microspheres. It requires the implementation of multimodality imaging, integrating metabolic, functional and structural characteristics. A multidisciplinary approach is a prerequisite for SIRT, bringing together the knowhow and expertise of radiologists, nuclear medicine physicians, medical physicists, imaging engineers, and radiotherapists. This review discusses the available radiologic (CT/MRI) and nuclear (SPECT/PET) imaging modalities and their specific utility in the different diagnostic phases related to SIRT: wholebody and intrahepatic pre-treatment disease staging, CT and MRI-based angiography, liver-lung shunt assessment, treatment simulation, predictive dosimetry, post-treatment imaging, and SIRT response assessment.

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90Y bremsstrahlung emission computed tomography using gamma cameras

Abstract: (90)Y BECT imaging can be used for patient assessment without modifying current treatment procedures.

Cited by 33 publications

References 16 publications

Technical Considerations of Phosphorous-32 Bremsstrahlung SPECT Imaging after Radioembolization of Hepatic Tumors: A Clinical Assessment with a Review of Imaging Parameters

Technical Considerations of Phosphorous-32 Bremsstrahlung SPECT Imaging after Radioembolization of Hepatic Tumors: A Clinical Assessment with a Review of Imaging Parameters

Quantitative Evaluation of Scintillation Camera Imaging Characteristics of Isotopes Used in Liver Radioembolization

New Imaging Techniques for 90Y Microsphere Radioembolization

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