Untitled

Abstract

Upper Aero digestive Tract (UADT) is the commonest site for the development of second cancer in females after primary cervical cancer. Glutathione S-transferase (GSTM1 and / or T1) null genotype modulates the risk of developing UADT cancer (primary as well as second cancer). The aim of this study was to evaluate the difference in GST null genotype frequencies in females with paired cancers in the UADT and genital region as compared to females with paired cancers in the UADT and non-genital region. Forty-nine females with a cancer in the UADT and another cancer (at all sites-genital and non-genital) were identified from a database of patients with multiple primary neoplasms and were analyzed for the GSTM1 and T1 genotype in addition to known factors such as age, tobacco habits, alcohol habits and family history of cancer. Frequencies of GSTM1 null, GSTT1 null, and either GSTM1/T1 null were higher in females with paired occurrence of cancer in the UADT and genital site (54%, 33% and 75% respectively) in comparison to females with paired occurrence of cancer in the UADT and non-genital sites (22%, 6% and 24% respectively). The significantly higher inherited frequency of either GSTM1/T1 null genotype in females with a paired occurrence of cancers in UADT and genital region (p = 0.01), suggests that these females are more susceptible to damage by carcinogens as compared to females who have UADT cancers in association with cancers at non-genital sites.

Case–control study and meta-analysis of SULT1A1 Arg213His polymorphism for gene, ethnicity and environment interaction for cancer risk

“…In contrast to the GST super family of enzymes that have been studied extensively for tobacco carcinogenesis (Nakajima et al, 1995;Cheng et al, 1999;Buch et al, 2002;Jhavar et al, 2004Jhavar et al, , 2005, other phase II metabolising enzymes such as the SULT have been less extensively studied (Hung et al, 2004;Dandara et al, 2006;Pachouri et al, 2006). There also has not been any collation of published data or a meta-analysis of case -control studies evaluating SULT enzyme in cancers.…”

“…However, it is possible that the variation is even larger if different Asian populations are taken in the study separately. We (Jhavar et al, 2004(Jhavar et al, , 2005 and others from India (Buch et al, 2002;Anantharaman et al, 2007) have reported a markedly lower frequency of GSTT1 null genotype in the Indian population as compared with that in the Japanese, Chinese and Korean population (Raimondi et al, 2006). Although marked geoethnic variation in the incidence of different cancers is attributed largely to the differences in carcinogenic exposure and diet, marked differences in the population frequency of the riskconferring genotype of some XMEs could also influence cancer risk.…”

Multiple Pathway-Based Genetic Variations Associated with Tobacco Related Multiple Primary Neoplasms

“…We have chosen a biologically enriched clinical model system of tobacco related multiple primary neoplasms (MPN-TRC). We had earlier hypothesized [5] , [10] , [15] , [16] that individuals who develop tobacco related MPN, represent a cohort of individuals with enhanced gene-environment and gene-gene interaction. Only recently, the unique biological and statistical utility of MPN in molecular epidemiological studies has been highlighted by others [6] .…”