934-25 Video Densitometric Analysis of Intracoronary Ultrasound Images-Anatomopathologic Correlation

Londero, Hugo; Laguens, Rubén M.; Telayna, Juan Manuel; González, Pedro; Serna, Fernando A. de la; Wisner, Jorge N.; Magariños, Eduardo; Méndiz, Oscar

doi:10.1016/0735-1097(95)92090-r

Cited by 2 publications

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“…In previous in vivo or ex vivo studies, calcified and fibrous plaques were well identified by their hyperechoic appearance and homogeneous echocardiographic reflection (1-3,14 -16). However, discrimination between lipid-containing and mixed (fibro-lipidic plaque), labeled as a region of low-density in gray scale IVUS remains difficult to achieve (1,2,17). Besides, analysis of tissue behind a calcification is difficult of signal attenuation.…”

Section: Discussionmentioning

confidence: 97%

Accuracy of In Vivo Coronary Plaque Morphology Assessment

Nasu

Tsuchikane

Katoh

et al. 2006

Journal of the American College of Cardiology

450

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Section: Discussionmentioning

confidence: 97%

Accuracy of In Vivo Coronary Plaque Morphology Assessment

Nasu

Tsuchikane

Katoh

et al. 2006

Journal of the American College of Cardiology

450

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“…13,14 However, another study reported that IVUS could distinguish whether a plaque contained calcium, but this capacity was limited to discriminating between fibrous and fatty plaques. 15 From the findings of our study, we consider that the inflammatory infiltrate is one of the important factors that cause not only the mean echo levels but also the irregular pattern of the echo levels.…”

Section: Discussionmentioning

confidence: 99%

Atherosclerotic Plaque Characterization by Quantitative Analysis Using Intravascular Ultrasound

Okimoto

Imazu

Hayashi

et al. 2002

Circ J

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acrophages and lymphocytes play a prominent role in atherosclerotic plaque formation, progression and rupture, which are responsible for the majority of acute coronary syndromes. [1][2][3][4][5] Macrophages also play a pivotal role in the restenosis process following coronary intervention. 6,7 Therefore, the real-time evaluation in vivo of infiltrated atherosclerotic plaque is of prime importance.Intravascular ultrasound (IVUS), which provides realtime in vivo tomographic images, is a useful technique for evaluating the histological character of atherosclerotic plaque, 8,9 and many researchers have reported a relationship between the tissues that form plaque and the intravascular echo levels in vitro. [10][11][12] A recent study demonstrated that IVUS images of atherosclerotic lesions in patients could be accurately characterized by quantitative analysis using a computer system, 13,14 but infiltrated atherosclerotic plaque has not been evaluated in patients with coronary artery disease.The purpose of the present study was to determine whether plaque morphology, as defined by the quantitative analysis of IVUS images using a commercially available Circulation Journal Vol.66, February 2002 software program, was related to the immunohistochemical findings. MethodsBetween September 1994 and April 1995, from a total of 36 non-stented native coronary lesions in 32 patients with coronary artery disease treated with directional coronary atherectomy (DCA) at Akane Foundation Tsuchiya General Hospital, we selected for analysis 25 lesions in 25 patients who had had ultrasound guidance during the DCA procedure. Selection of lesions was based on good quality IVUS images and a lack of shadows caused by superficial calcium deposits. All patients gave informed consent.The indications for revascularization were based on spontaneous or induced evidence of myocardial ischemia. Acute coronary syndromes were defined as unstable angina and myocardial infarction. Unstable angina was defined as new onset angina, worsening effort angina or angina at rest. Myocardial infarction was defined as the occurrence of typical symptoms, electrocardiographic changes and creatine kinase elevation to twice the upper limit of normal.All patients were premedicated with aspirin and received heparin 10,000 IU during the procedure. Cardiac catheterization and intervention were performed according to standard techniques. When the operator considered the procedure to be completed, according to the angiographic findings, the atherocath was removed leaving the wire in place. Then, the samples of plaque were removed from the atherocath and sent for histopathological analysis. No major complications occurred in any of the 25 patients and revascularization

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934-25 Video Densitometric Analysis of Intracoronary Ultrasound Images-Anatomopathologic Correlation

Cited by 2 publications

References 0 publications

Accuracy of In Vivo Coronary Plaque Morphology Assessment

Accuracy of In Vivo Coronary Plaque Morphology Assessment

Atherosclerotic Plaque Characterization by Quantitative Analysis Using Intravascular Ultrasound

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