974. Dysregulation of Hypothalamic-Pituitary-Adrenal Axis and Sympathoadrenergic System is Associated with Posttraumatic Stress Disorder in Combat Veterans

Rhind, Shawn G.; Jetly, Rakesh; Richardson, Donald J.; Battista, A.; Lanius, Ruth A.

doi:10.1016/j.biopsych.2017.02.700

Cited by 3 publications

(2 citation statements)

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“…The role of the hypothalamic-pituitary-adrenal (HPA) axis and its endproduct cortisol in the precipitation of posttraumatic stress disorder (PTSD), is well-documented Yehuda (2000); Pitman (2012) In veteran PTSD patients, commonly hypocorticolism is measured for instance in e. g. the socalled 'cortisol awakening response', likely because of enhanced glucocorticoid feedback (Wingenfeld et al, 2015;Rhind et al, 2017;Rauch et al, 2020). However, the literature also presents data on significant increases in blood as well as hair cortisol levels of PTSD patients (Song et al, 2008;Steudte et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Biomarkers in PTSD-susceptible and resistant veterans with war experience of more than ten years ago: FOCUS ON cortisol, thyroid hormones, testosterone and GABA

Feklicheva

Boks

Kloet

et al. 2022

Journal of Psychiatric Research

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Section: Introductionmentioning

confidence: 99%

Biomarkers in PTSD-susceptible and resistant veterans with war experience of more than ten years ago: FOCUS ON cortisol, thyroid hormones, testosterone and GABA

Feklicheva

Boks

Kloet

et al. 2022

Journal of Psychiatric Research

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“…Different molecular and cellular aspects of the disorder have been studied and discussed in detail [5][6][7]. The significant role of several hormones, such as cortisol, in PTSD is introduced and emphasized [8][9][10]. Genome-wide studies about PTSD have provided valuable information about the mechanism of the disease [11,12].…”

Section: Introductionmentioning

confidence: 99%

Protein-Protein Interaction Network Analysis Revealed a New Prospective of Posttraumatic Stress Disorder

Tavirani¹,

Okhovatian²,

Rostami-Nejad³

et al. 2018

GMJ

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Background: Posttraumatic stress disorder (PTSD) is known by a number of mental disorders, including recurring memories of trauma, mental appalling, and escaping of sign that make them recall the trauma in question. Clinical interviews serve as the main diagnostic tool for PTSD. With respect to treatment, either pharmacotherapy or psychotherapy or a combination of both is used as a therapeutic method for PTSD. In this study, a number of crucial genes related to PTSD, which can be considered as biomarker candidates, were represented. Materials and Methods: The genes related to PTSD were extracted from the STRING database and organized in a protein-protein interaction network with the help of Cytoscape software version 3.6.0. The network was analyzed, and the important genes were introduced based on central indices. The biological processes related to the crucial genes were enriched via gene ontology using ClueGO. Results: From a total of 100 genes, 63 genes were extracted that formed the main connected component, and of these, 12 crucial genes¾POMC, BDNF, FOS, NR3C1, CRH, IL6, NPS, HTR1A, NPY, CREB1, CRHR1, and TAC1¾were introduced. Biological processes were classified into the regulation of corticosterone, regulation of behavior, response to fungus, multicellular organism response to stress, and associative learning. Conclusion: The introduced 12 crucial genes can be used as a biomarker panel related to PTSD and can be considered as a diagnostic reagent or drug target; however, more investigations are needed to use these genes as biomarkers.[GMJ.2018;7:e1137]

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Catecholamines in Post-traumatic Stress Disorder: A Systematic Review and Meta-Analysis

Pan

Kaminga

Wen

et al. 2018

Front. Mol. Neurosci.

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Studies on the association between post-traumatic stress disorder (PTSD) and levels of catecholamines have yielded inconsistent results. The aim of this study was to conduct a systematic review and meta-analysis to assess whether concentrations of the catecholamines dopamine, norepinephrine, and epinephrine are associated with PTSD. This study searched relevant articles in the following databases: PubMed, Embase, Web of Science, and Psyc-ARTICLES. Each database was searched from its inception to September, 2018. Data related to catecholamine concentrations were extracted for patients with PTSD and the controls to calculate standardized mean differences and to evaluate effect sizes. A meta-analysis was then performed to compare the concentration of each catecholamine between the two groups in blood and/or urine samples. Heterogeneity was quantified using I2 and its significance was tested using the Q statistics. Subgroup analyses of the types of controls, PTSD assessment tools, and assayed methods used in the studies were performed to explore sources of heterogeneity among studies. Random-effects models were used to combine results from selected studies. A total of 1,388 articles were identified, of which 27 were included in the final analysis. Heterogeneity was high; hence random-effects models were used to combine results of selected studies. Results revealed significantly higher norepinephrine levels in people with PTSD than in the controls [standardized mean difference (SMD) = 0.35, 95% confidence interval (CI): 0.13 to 0.57, p = 0.002]. No difference was found in dopamine and epinephrine concentrations between the two groups. Elevated norepinephrine levels may be an important indicator for PTSD.

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974. Dysregulation of Hypothalamic-Pituitary-Adrenal Axis and Sympathoadrenergic System is Associated with Posttraumatic Stress Disorder in Combat Veterans

Cited by 3 publications

References 0 publications

Biomarkers in PTSD-susceptible and resistant veterans with war experience of more than ten years ago: FOCUS ON cortisol, thyroid hormones, testosterone and GABA

Biomarkers in PTSD-susceptible and resistant veterans with war experience of more than ten years ago: FOCUS ON cortisol, thyroid hormones, testosterone and GABA

Protein-Protein Interaction Network Analysis Revealed a New Prospective of Posttraumatic Stress Disorder

Catecholamines in Post-traumatic Stress Disorder: A Systematic Review and Meta-Analysis

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