99mTc-cystine: A faster excreting99mTc-glucoheptanoate analogue

Chattopadhyay, M.; Jalan, K. N.; Pal, Amit; Banerjee, Sumanta

doi:10.1016/s0969-8051(88)80012-x

Cited by 2 publications

(6 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, it is not possible to extend this method to prepare 99m Tc cysteine where the presence of a large amount of cysteine with respect to this isotope of technetium is unavoidable because of the low concentration of the tracer (10 -8 M) used for such preparation. However, under the above condition the disulfide (cystine) can be used to produce the desired cysteine complex of 99m Tc in nearly quantitative yield …”

Section: Discussionmentioning

confidence: 99%

“…In view of these findings we reasoned that it would be more appropriate to use cystine as the starting material for the preparation of technetium cysteinate because cystine can readily undergo metal-induced disulfide cleavage and this would exclude the presence of excess thiolate in the reaction mixture. 99m Tc−cysteine prepared in this way has been found to interact with renal tubular transport protein and proved to be a valuable radiopharmaceutical for clinical evaluation of renal patients …”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Oxorhenium(V) and Oxotechnetium(V) Complexes of Cysteine

et al. 1998

View full text Add to dashboard Cite

Earlier attempts to obtain technetium complexes with cysteine always resulted in the formation of a product contaminated with polymeric species. A pure product, which could be chemically characterized and adopted for radiopharmaceutical preparation, has now been obtained by using cystine as the precursor of cysteine. This method has been extended to prepare the corresponding rhenium chelate, isolated as the tetraphenylphosphonium salt [Ph(4)P](+)[{ReO(Cys)(2)}(-){HReO(Cys)(2)}].4H(2)O. The X-ray crystal structure of this compound revealed the presence of both neutral and anionic chelated species. In [HReO(Cys)(2)], the cysteine carboxylate moiety is unidentatedly bound to rhenium, while the carboxylic acid of the second cysteine remains as free COOH. The coordination environment around rhenium in the anionic species [ ReO(Cys)(2)(-)] is similar, the only difference being that the uncoordinated carboxylate moiety is present as a COO(-) anion. The thiolate, amine coordination of the ligand with the metal is present in both the chelate units. The compound crystallized in an orthorhombic system with the space group P2(1)2(1)2(1), and having four formula units in each cell. The crystal data are a = 9.700(2) Å, b = 12.836(3) Å, and c = 36.228(3) Å. The rhenium chelate has been structurally correlated with the technetium chelates through comparable spectroscopic and chromatographic data. The technetium-99m analogue of this rhenium chelate exhibited renal tubular transport and renal retention, which makes this radiopharmaceutical useful for evaluation of the clinical status of renal patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Oxorhenium(V) and Oxotechnetium(V) Complexes of Cysteine

et al. 1998

View full text Add to dashboard Cite

show abstract

“…7 The previous results show very good properties of Tc-99m cystine complex for evaluation of renal function in animals, 7-9 normal volunteers, chronic renal failure patients, and transplant patients. 10 Tc-99m cystine and Re-186 cystine isolated in milligram quantities and characterized by x-ray crystallography in our laboratory, clearly explains the renal properties and mechanism of the tubular secretion of Tc-99m cystine as a hippurate analog and its retention in the kidney like organomercurials.…”

Section: Discussionmentioning

confidence: 81%

“…10 Tc-99m MAG3 kits have been purchased from Mallinckrodt Medical BV, Petten, Holland and have been prepared by a standard method reported in the literature. [7][8][9] Subjects All subjects, volunteers, and patients gave informed consent and were selected from amongst kidney donors (normal volunteers) and patients referred for radionuclide evaluation of renal function. Eleven subjects with normal renal function (determined by intravenous pyelogram, ultrasound blood chemistry, and DTPA study) consisted of the group representing normal volunteers (10 men and 1 woman aged 20 -46 years).…”

Section: Radiopharmaceutical Preparationmentioning

confidence: 99%

See 1 more Smart Citation

Comparative Evaluation of Tc-99m Cystine and Tc-99m MAG3 in Normals and Patients With Renal Functional Impairment

Misra

Pradhan²,

Kyle³

et al. 2009

Clinical Nuclear Medicine

View full text Add to dashboard Cite

Tc-99m cystine has been proved to be a good renal agent in animals for morphologic as well as the functional status of the kidney. In this study, we compared Tc-99m cystine with Tc-99m mercaptoacetyltriglycine, which is used for evaluation of renal function in normal patients, and those with various degrees of renal functional impairment. The clearance values and static images are compared with Tc-99m mercaptoacetyltriglycine. The results show that Tc-99m cystine has good radiopharmaceutical characteristics suitable for evaluation of both renal function as well as morphology.

show abstract

99mTc-cystine: A faster excreting99mTc-glucoheptanoate analogue

Cited by 2 publications

References 2 publications

Oxorhenium(V) and Oxotechnetium(V) Complexes of Cysteine

Oxorhenium(V) and Oxotechnetium(V) Complexes of Cysteine

Comparative Evaluation of Tc-99m Cystine and Tc-99m MAG3 in Normals and Patients With Renal Functional Impairment

Contact Info

Product

Resources

About