99mTc-TRODAT-1 SPECT study in early Parkinson's disease and essential tremor

Wang, J.; Jiang, Yuping; Liu, X.-D.; Chen, Z.-P.; Long, Yang; Liu, C.-J.; Xiang, Jing-De; Su, Hui-Lin

doi:10.1111/j.1600-0404.2005.00517.x

Cited by 33 publications

(13 citation statements)

References 26 publications

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“…The reduced dopaminergic uptake pattern differed between the studies. Alternatively, the majority of DAT-SPECT and DOPA-PET studies did not show any deviations in striatal uptake in a total of 168 essential tremor patients (Brooks et al, 1992; Breit et al, 2006; Antonini et al, 2001; Doepp et al, 2008; Wang et al, 2005; Asenbaum et al, 1998; Benamer et al, 2000; Di et al, 2012; Isaias et al, 2010; Roselli et al, 2010; Parkinson study group, 2000). The two largest amongst these studies, with groups of 27 and 32 essential tremor patients, included patients fulfilling the clinical criteria and without any signs of parkinsonism (Asenbaum et al, 1998; Benamer et al, 2000).…”

Section: Resultsmentioning

confidence: 95%

“…Most scintigraphic studies looking into the basal ganglia found no dopaminergic deficits in essential tremor (Antonini et al, 2001; Asenbaum et al, 1998; Benamer et al, 2000; Breit et al, 2006; Brooks et al, 1992; Doepp et al, 2008; Isaias and Antonini, 2010; Wang et al, 2005) while two studies measured slight abnormalities (Gerasimou et al, 2012; Isaias et al, 2008). One study reported iron accumulation in the basal ganglia (Novellino et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

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Neuroimaging essentials in essential tremor: A systematic review

Sharifi

Nederveen

Booij

et al. 2014

NeuroImage: Clinical

129

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BackgroundEssential tremor is regarded to be a disease of the central nervous system. Neuroimaging is a rapidly growing field with potential benefits to both diagnostics and research. The exact role of imaging techniques with respect to essential tremor in research and clinical practice is not clear. A systematic review of the different imaging techniques in essential tremor is lacking in the literature.MethodsWe performed a systematic literature search combining the terms essential tremor and familial tremor with the following keywords: imaging, MRI, VBM, DWI, fMRI, PET and SPECT, both in abbreviated form as well as in full form. We summarize and discuss the quality and the external validity of each study and place the results in the context of existing knowledge regarding the pathophysiology of essential tremor.ResultsA total of 48 neuroimaging studies met our search criteria, roughly divided into 19 structural and 29 functional and metabolic studies. The quality of the studies varied, especially concerning inclusion criteria. Functional imaging studies indicated cerebellar hyperactivity during rest and during tremor. The studies also pointed to the involvement of the thalamus, the inferior olive and the red nucleus. Structural studies showed less consistent results.Discussion and conclusionNeuroimaging techniques in essential tremor give insight into the pathophysiology of essential tremor indicating the involvement of the cerebellum as the most consistent finding. GABAergic dysfunction might be a major premise in the pathophysiological hypotheses. Inconsistencies between studies can be partly explained by the inclusion of heterogeneous patient groups. Improvement of scientific research requires more stringent inclusion criteria and application of advanced analysis techniques. Also, the use of multimodal neuroimaging techniques is a promising development in movement disorders research. Currently, the role of imaging techniques in essential tremor in daily clinical practice is limited.

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Section: Resultsmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Neuroimaging essentials in essential tremor: A systematic review

Sharifi

Nederveen

Booij

et al. 2014

NeuroImage: Clinical

129

View full text Add to dashboard Cite

show abstract

“…6 In addition to FP-CIT, the availability of DAT binding sites can also be measured with other tracers, such as iodine-123-beta-carbomethoxy-3 beta-(4-iodophenyltropane) (b)CIT or [99mTc]TRODAT-1. [7][8][9][10][11][12] To analyze DAT-SPECT images three different methods are available, that is, the visual assessment, the region of interest (ROI) approach, and the voxel-based analysis. We summarize the characteristics of the named methods to analyze DAT-SPECT images and review their potential for various clinical and experimental indications.…”

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confidence: 99%

Dopamine transporter SPECT: How to remove subjectivity?

Scherfler

Nocker

2009

Movement Disorders

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Clinical criteria enable accurate and reliable diagnosis of parkinsonian syndromes when cardinal clinical features are fully developed. Single photon emission computed tomography (SPECT) investigating the striatal dopamine transporter (DAT) status have been suggested to increase the diagnostic accuracy in uncertain parkinsonian syndromes such as isolated tremor symptoms not fulfilling essential tremor criteria, as well as drug-induced, vascular and psychogenetic parkinsonism. Several approaches for the analysis of the striatal DAT distribution have been tested for their ability to analyze and quantify SPECT images. Visual assessment of DAT binding and semiquantitative analysis using region of interests have been recommended by Nuclear Medicine Associations to be incorporated in the routine work-up of DAT-SPECT. Besides these observer dependent approaches, fully automated image-analysis techniques have been validated in the clinical setting. Their potential as tools to improve the diagnostic accuracy in patients presenting with parkinsonian features is reviewed here.

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“…Studies of ( 99m Tc)‐TRODAT‐1 have also shown significantly reduced striatal uptake in PD compared to non‐degenerative causes of Parkinsonism, such as essential tremor, vascular Parkinsonism and drug‐induced Parkinsonism . However, PD cannot be reliably distinguished from atypical Parkinsonian syndromes (which are also characterised by dopaminergic degeneration), such as multiple system atrophy, corticobasal degeneration and progressive supranuclear palsy .…”

Section: Discussionmentioning

confidence: 99%

Clinical utility of (^99mTc)‐TRODAT‐1 scans to differentiate Parkinsonian syndromes: case studies and commentary

Wong

Veitch

Schembri

2018

Internal Medicine Journal

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The differential diagnosis of Parkinsonian syndromes is challenging, especially in the elderly as they often have complex presentations. Nuclear imaging modalities can increase diagnostic accuracy. Single-photon emission tomography (SPECT) using the ligand ( Tc)-TRODAT-1 is used overseas but is yet to be approved in Australia. Three pilot cases of clinically unclear Parkinsonian syndromes from the Royal North Shore Hospital Aged Care Department who underwent ( Tc)-TRODAT-1 scans are described. From experience overseas, the ( Tc)-TRODAT-1 scan has clinical utility in the differential diagnosis of Parkinsonian syndromes. ( Tc)-TRODAT-1 has a lower cost and greater availability than other ligands. Our initial scan findings are largely consistent with the clinical picture, but low specific binding can affect scan interpretation. ( Tc)-TRODAT-1 is a potential tool in the differential diagnosis of Parkinsonian syndromes. Further experience regarding its effect on patient outcomes and cost effectiveness is required before routine clinical use can be recommended.

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99mTc-TRODAT-1 SPECT study in early Parkinson's disease and essential tremor

Abstract: 99mTc-TRODAT-1 SPECT can detect the dysfunction of nigrostriatal system in patients with early PD and provided a feasible tool to help differentiate early PD from ET.

Cited by 33 publications

References 26 publications

Neuroimaging essentials in essential tremor: A systematic review

Neuroimaging essentials in essential tremor: A systematic review

Dopamine transporter SPECT: How to remove subjectivity?

Clinical utility of (^99mTc)‐TRODAT‐1 scans to differentiate Parkinsonian syndromes: case studies and commentary

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99mTc-TRODAT-1 SPECT study in early Parkinson's disease and essential tremor

Abstract: 99mTc-TRODAT-1 SPECT can detect the dysfunction of nigrostriatal system in patients with early PD and provided a feasible tool to help differentiate early PD from ET.

Cited by 33 publications

References 26 publications

Neuroimaging essentials in essential tremor: A systematic review

Neuroimaging essentials in essential tremor: A systematic review

Dopamine transporter SPECT: How to remove subjectivity?

Clinical utility of (99mTc)‐TRODAT‐1 scans to differentiate Parkinsonian syndromes: case studies and commentary

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Clinical utility of (^99mTc)‐TRODAT‐1 scans to differentiate Parkinsonian syndromes: case studies and commentary