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Herpes virus ICP47 and US11 suppression of CTL activity adapted for use in gene therapy

“…MoMLV transduction into lymphocytes can be difficult to achieve [23][24][25]. To determine if TALL-104 or NK-92 cells could be transduced, two vectors encoding humanized, red-shifted green fluorescent protein (eGFP) were used [26].…”

“…Without peptide, immature class I MHC molecules are retained in the ER and do not get displayed on the cell surface. HCMV uses at least five proteins to interrupt the presentation of class I MHC on the cell surface [23]. One of the more effective proteins is encoded by the USl 1 gene [24,25].…”