(9βH)-Pimaranes and Derivatives from the Tuber of <i>Icacina trichantha</i>

Zhao, Ming; Onakpa, Monday M.; Santarsiero, Bernard D.; Chen, Wei‐Lun; Szymulanska-Ramamurthy, Karina M.; Swanson, Steven M.; Burdette, Joanna E.; Che, Chun‐Tao

doi:10.1021/acs.jnatprod.5b00688

Cited by 25 publications

(38 citation statements)

References 9 publications

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“…37 It was found to be potently cytotoxic in all cases in the present study (Tables 3 and 6). Hence, (+)-strebloside ( 5 ) exhibits a broad spectrum of action toward both human solid tumor and leukemic cells.…”

Section: Resultssupporting

confidence: 55%

Cardiac Glycoside Constituents of Streblus asper with Potential Antineoplastic Activity

et al. 2016

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Three new (1–3) and two known (4 and 5) cytotoxic cardiac glycosides were isolated and characterized from a medicinal plant, Streblus asper, collected in Vietnam, with six new and one known derivatives (5a–5g) synthesized from (+)-strebloside (5). A preliminary structure-activity relationship study indicated that the C-19 formyl and C-5 and C-14 hydroxy groups and C-3 sugar unit play important roles in the mediation of the cytotoxicity of (+)-strebloside (5) against HT-29 human colon cancer cells. When evaluated in NCr nu/nu mice implanted intraperitoneally with hollow fibers facilitated with either MDA-MB-231 human breast or OVCAR3 human ovarian cancer cells, (+)-strebloside (5) showed significant cell growth inhibitory activity in both cases, in the dose range 5–30 mg/kg.

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Section: Resultssupporting

confidence: 55%

Cardiac Glycoside Constituents of Streblus asper with Potential Antineoplastic Activity

et al. 2016

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“…are a rich source of diterpenoids with (9βH)-17norpimarane and (9bH)-pimarane structures, the latest being a very rare structural class. 17-hydroxyicacinol (07), icacinol (08), and humirianthol (09), as well as two (9bH)-17-norpimaranes, humirianthenolide C (10) and icacenone (11), and the icacinlactones A-G (12-18) exhibited cytotoxic activity against MDA-MB-435 in the low micromolar range with humirianthenolide C being the most potent of all, [44][45][46].…”

Section: Pimaranesmentioning

confidence: 99%

Natural Cytotoxic Diterpenoids, a Potential Source of Drug Leads for Melanoma Therapy

Prieto

Silveira

2019

CPD

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Diterpenes present complex structure and due to their unique carbon skeleton and interesting biological activities, have been the focus of continuous studies for the development of new anticancer agents. Phorbol esters have been known for their activity against skin malignancies since ancient times. Taxol was first studied in melanoma cells, and recently ingenol mebutate has been approved for the chemoprevention of melanoma in actinic keratosis patients. Therefore, there is scope for research on this class of compounds. We here aim to review the relevant original research reporting on isolated diterpenes with cytotoxic and/or antitumoral activities upon melanoma cells. By collating and discussing the implications of past and current developments on diterpenes, we hope to steer further interest on this field and facilitate the drug discovery activities of the scientific community towards finding potential alternatives to current melanoma chemotherapy.

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“…The diterpenes from Callicarpa longissima (Liu et al , ), Clerodendrum splendens (Faiella et al , ), Fagonia mollis (Sallam et al , ), Icacina trichantha (Zhao et al , ), Hedychium longipetalum (Zhao et al , ), Micromonospora sp. (Mullowney et al , ), Cespitularia taeniata (Wang et al , ), Caesalpinia spinosa (He et al , ), Nephthea columnaris (Hsiao et al , ), Bursera microphylla (Messina et al , ), Teucrium viscidum (Gao et al , ), Euphorbia ebracteolata (Yuan et al , ), Euphorbia aellenii (Yazdiniapour et al , ), Perenniporia subacida (Wen et al , ), Abies fargesii (Wu et al , ) and Premna tomentosa (Rekha et al , ) were also evident to exert cytotoxic effects on a number of human cancer cell lines.…”

Section: Diterpenic Anticancer Traitsmentioning

confidence: 99%

Diterpenes and Their Derivatives as Potential Anticancer Agents

Islam

2017

Phytotherapy Research

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As therapeutic tools, diterpenes and their derivatives have gained much attention of the medicinal scientists nowadays. It is due to their pledging and important biological activities. This review congregates the anticancer diterpenes. For this, a search was made with selected keywords in PubMed, Science Direct, Web of Science, Scopus, The American Chemical Society and miscellaneous databases from January 2012 to January 2017 for the published articles. A total 28, 789 published articles were seen. Among them, 240 were included in this study. More than 250 important anticancer diterpenes and their derivatives were seen in the databases, acting in the different pathways. Some of them are already under clinical trials, while others are in the nonclinical and/or pre-clinical trials. In conclusion, diterpenes may be one of the lead molecules in the treatment of cancer. Copyright © 2017 John Wiley & Sons, Ltd.

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(9βH)-Pimaranes and Derivatives from the Tuber of Icacina trichantha

Cited by 25 publications

References 9 publications

Cardiac Glycoside Constituents of Streblus asper with Potential Antineoplastic Activity

Cardiac Glycoside Constituents of Streblus asper with Potential Antineoplastic Activity

Natural Cytotoxic Diterpenoids, a Potential Source of Drug Leads for Melanoma Therapy

Diterpenes and Their Derivatives as Potential Anticancer Agents

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