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Vrhovnik, K; Kristl, Julijana; Šentjurc, Marjeta; Smid-Korbar, J.

doi:10.1023/a:1011965423986

Cited by 64 publications

(13 citation statements)

References 4 publications

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“…Permeation flux of NIM using RS was markedly higher with plain drug solution (30.36 µg/cm 2 /h) than with liposomal suspension (14.13 µg/cm 2 /h) and liposomal gel (10.62 µg/cm 2 /h). Unequivocally, it indicates drug release retarding or drug holding capacity of the liposomes, in accordance with the findings reported earlier [47,48]. Relatively lower amounts of NIM permeated through HCS vis-à-vis through RS, as observed in all the three studied formulations, may be ascribed to more lipoidal nature and thicker layers of HCS.…”

Section: Skin Permeation Studiessupporting

confidence: 91%

Design, Development and Optimization of Nimesulide-Loaded Liposomal Systems for Topical Application

Singh¹,

Mehta²,

Kumar³

et al. 2005

CDD

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Nimesulide, a non-steroidal anti-inflammatory drug, was incorporated into multilamellar liposomes to improve its performance on topical administration. The drug was loaded onto liposomes employing thin film hydration technique. Various process and formulation variables were investigated to obtain the liposomal products of desired quality. Liposomes were monitored for percent drug entrapment, after separating the unentrapped drug by mini column centrifugation, for vesicular properties (such as size distribution profile, morphological attributes and agglomeration tendency), drug diffused through synthetic semipermeable membrane, and drug leakage. Systematic optimization studies were carried out using 3(2) factorial design to select the optimized liposomal composition with reference to percent drug entrapment, drug diffusion and leakage. The optimized batch of liposomes was subjected to drug permeation and drug retention studies employing rat skin and human cadaver skin. In comparison to methanolic solution of pure nimesulide, liposomal formulations were found to retain higher amounts of nimesulide in the skin. Anti-inflammatory studies, using carragenan-induced rat paw edema model, indicated significantly better performance of liposomally entrapped nimesulide in comparison to the marketed gel formulation and the Carbopol gel containing nimesulide.

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Section: Skin Permeation Studiessupporting

confidence: 91%

Design, Development and Optimization of Nimesulide-Loaded Liposomal Systems for Topical Application

Singh¹,

Mehta²,

Kumar³

et al. 2005

CDD

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“…31 Liposomes maintain natural fluidity of lipid bilayers, in contrast to supported lipid bilayer where binding of the inner layer of lipid to the solid surface may decrease fluidity of the lipid bilayer. 32 The defined size, composition, homogeneity, and availability of large-batch production of liposomes have made them useful for the study of diverse cellular phenomena. 33 In many cases, however, the successful use of liposomes depends on their formulation and the method of preparation and can be used for robust high-throughput screening assays.…”

Section: Introductionmentioning

confidence: 99%

Role of Nanoparticle Surface Functionality in the Disruption of Model Cell Membranes

et al. 2012

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Lipid bilayers are biomembranes common to cellular life and constitute a continuous barrier between cells and their environment. Understanding the interaction of engineered nanomaterials (ENMs) with lipid bilayers is an important step toward predicting subsequent biological effects. In this study, we assess the effect of varying the surface functionality and concentration of 10 nm-diameter gold (Au) and titanium dioxide (TiO2) ENMs on the disruption of negatively charged lipid bilayer vesicles (liposomes) using a dye leakage assay. Our findings show that Au ENMs having both positive and negative surface charge induce leakage that reaches a steady state after several hours. Positively charged particles with identical surface functionality and different core composition show similar leakage effects and result in faster and greater leakage than negatively charged particles, which suggests that surface functionality, not particle core composition, is a critical factor in determining the interaction between ENMs and lipid bilayers. The results suggest that particles permanently adsorb to bilayers and that only one positively charged particle is required to disrupt a liposome and trigger leakage of its entire contents in contrast to mellitin molecules, the most widely studied membrane lytic peptide, which requires hundred of molecules to generate leakage.

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“…It has been shown to modify the order and mobility of the phospholipids in the bilayer [20,21] and as a consequence, it alters the bilayer fluidity. Other studies indicate that cholesterol content might be of crucial importance for the effective delivery of liposome-entrapped substances into the skin [22]. Coderch et al (2000) observed contrary effects of cholesterol depending on the degree of saturation of the employed lipid [23].…”

Section: Discussionmentioning

confidence: 98%

Experimental design for in vitro skin penetration study of liposomal superoxide dismutase

Braun

Wagner

Fürnschlief

et al. 2006

Journal of Pharmaceutical and Biomedical Analysis

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Abstract: It can be concluded that the domain structure of the liposome bilayer is more important for the delivery of encapsulated substance into the skin than the liquid crystalline phase of the pure phospholipids bilayer.

Cited by 64 publications

References 4 publications

Design, Development and Optimization of Nimesulide-Loaded Liposomal Systems for Topical Application

Design, Development and Optimization of Nimesulide-Loaded Liposomal Systems for Topical Application

Role of Nanoparticle Surface Functionality in the Disruption of Model Cell Membranes

Experimental design for in vitro skin penetration study of liposomal superoxide dismutase

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