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Sahin, Murathan; Yapici, Oktay; Dervişoğlu, Adem; Başoğlu, Tarık; Canbaz, Fevziye; Albayrak, Selahattin; Citak, Ayse

doi:10.1097/00003072-200107000-00004

Cited by 18 publications

(4 citation statements)

References 11 publications

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“…Five of those had metastases in lymph nodes [ 26 ]. In 1999, Gallowitsch et al and subsequently, in 2001, Sahin et al applied the radioisotope method to localize the SLN in thyroid cancer patients [ 27 , 28 ]. However, until now, in a majority of cases of sentinel lymph node mapping in thyroid carcinoma, the dye method has solely been employed [ 29 , 30 ].…”

Section: Discussionmentioning

confidence: 99%

One-step nucleic acid amplification analysis of sentinel lymph nodes in papillary thyroid cancer patients

Kaczka¹,

Pomorski²

2017

aoms

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IntroductionIt is essential to look for methods to define the need for central lymphadenectomy for papillary thyroid cancer patients. The aim is to determine the efficacy of one-step nucleic acid amplification (OSNA) and sentinel lymph node (SLN) biopsy in the intraoperative detection of nodal involvement.Material and methodsThis prospective, experimental study enrolled 49 patients with clinically negative lymph nodes. Intraoperatively, 1% Patent Blue dye was injected intratumorally. Lymph nodes that stained blue were defined as SLNs. They were directly cut into blocks at 2-mm intervals. Nonadjacent blocks were subjected to either the OSNA assay or histological examination.ResultsSixty-five SLNs were found in 43 (87.8%) patients. There were 20 (30.8%) histopathologically positive SLNs. According to the OSNA, 22 (33.8%) SLNs were positive. The OSNA results were different from histopathology in 8 (12.3%) SLNs. The OSNA gave a positive result in 5 (7.7%) SLNs, while they were not involved according to the histopathology. However, OSNA upstaged N status from N0 to N1 only in 2 (3.1%) patients. Inverse results (histopathology +, OSNA–) were obtained in 3 (4.6%) SLNs. Positive and negative predictive values (PPV and NPV) for OSNA were 0.77 and 0.93, respectively. The concordance rate between examinations was 85.5%.ConclusionsIn some patients with clinically negative lymph nodes, OSNA and SLN biopsy may prevent unnecessary central lymphadenectomy. On the other hand, the sentinel lymph node biopsy may reveal the presence of potentially involved sentinel lymph nodes outside the central compartment. These SLNs can also be assessed by means of OSNA.

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Section: Discussionmentioning

confidence: 99%

One-step nucleic acid amplification analysis of sentinel lymph nodes in papillary thyroid cancer patients

Kaczka¹,

Pomorski²

2017

aoms

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“…used radioisotopes for the same purpose. Both reported favorable results for detecting SLNs by this technique [35, 36]. A few meta-analyses have evaluated the usefulness of SLNB in thyroid surgery [37, 38].…”

Section: Discussionmentioning

confidence: 99%

Sentinel lymph node in thyroid tumors – own experience

Kaczka

Luks²,

Jasion³

et al. 2013

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Aim of the studyTo determine the feasibility of sentinel lymph node biopsy (SLNB) for the evaluation of the cervical lymph node status in patients with thyroid tumors.Material and methodsTwenty-three patients with suspected thyroid cancer were enrolled in the study. 0.5–1.0 ml of 1% Patent Blue dye was injected intratumorally. After SLNB, thyroidectomy and proper lymphadenectomy were performed.ResultsSentinel lymph node was detected in 20 (86.9%) patients. Thirty-one SLNs were found – 21 (67.7%) were located in the central neck compartment, 4 (12.9%) in the lateral neck compartment, 6 (19.4%) in the upper mediastinum. The number of SLNs ranged from 1 to 3 (mean 1.6). Sentinel lymph node was positive in 5 (25%) patients, negative in 15 (75%) in the final histopathology.Sentinel lymph nodes were located only in the central neck compartment in 13 patients, and in both the central and lateral neck compartments in 2 patients. In one patient, SLNs were located only in the central neck compartment and upper mediastinum. Three patients had SLNs only in the upper mediastinum, while one had them only in the lateral neck compartment. In one patient a node regarded as SLN was negative, while there were metastases in removed non-sentinel lymph nodes (NSLNs). In two patients, histopathology of SLNs showed that they were actually parathyroid glands.ConclusionsOur results confirm that thyroid cancer SLNB is rather easy to carry out. Its performance along with intraoperative examination can help to avoid unnecessary lymphadenectomy. However, it should be kept in mind that parathyroid glands can be stained and removed by mistake during SLNB.

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“…This technique has also been utilized in patients with thyroid cancer, using vital blue dye [10], or a radioisotope with favorable results observed in patients with PTC [11,12]. A complementary method, preoperative lymphoscintigraphy defines the drainage basins and SLN locations of individual tumors [13].…”

Section: Introductionmentioning

confidence: 99%

The usefulness and accuracy of sentinel lymph node biopsy using single photon emission computed tomography/computed tomography with 99mTc phytate to detect locoregional lymph node metastases in patients with papillary thyroid carcinoma

Lee

et al. 2013

J Korean Surg Soc

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PurposeRegional lymph node (LN) metastases are detected in 57-85% of patients with papillary thyroid carcinoma (PTC) and are associated with increased tumor recurrence. However, the management of lymphatic disease in patients with PTC has been ongoing source of debate. We have prospectively assessed the usefulness and accuracy of sentinel LN (SLN) biopsy for the detection of LN metastases in patients with PTC on preoperative imaging using single photon emission computed tomography/computed tomography (SPECT/CT) and 99mTc phytate.MethodsWe prospectively assessed 39 patients with PTC who had risk factors for recurrence or with the necessity of intraoperative LN sampling for suspicious LN metastases on preoperative imaging from August 2010 to March 2011. The patients underwent preoperative lymphoscintigraphy and SPETC/CT and intraoperative SLN biopsy (SLNB).Results99mTc lymphoscintigraphy and SPECT/CT localized SLN in 38 patients (97.4%), with the gamma probe identifying 2.15 mean SLNs in the lateral neck of the 39 patients. Skip metastasis was found in one patient, and lateral compartment LN metastasis in 17 (43.5%). The sensitivity, specificity, and accuracy of SLNB for lateral compartment LN metastasis were 88.2%, 100%, and 94.8%, respectively. SLNB was more accurate and useful for lateral than for central compartment LN metastasis.ConclusionSPECT/CT improved SLN detection and anatomical localization compared with lymphoscintigraphy. SLNB in patients with risk factors for recurrence or the necessity of intraoperative LN sampling for suspected LN metastases on preoperative imaging was accurate in detecting LN metastases and may help in deciding whether to perform lateral compartment dissection in patients with PTC.

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Abstract: Preoperative visualization of lymphatic pathways may be used when planning for thyroid cancer surgery. Sentinel node detection could yield valuable additional information in these patients.

Cited by 18 publications

References 11 publications

One-step nucleic acid amplification analysis of sentinel lymph nodes in papillary thyroid cancer patients

One-step nucleic acid amplification analysis of sentinel lymph nodes in papillary thyroid cancer patients

Sentinel lymph node in thyroid tumors – own experience

The usefulness and accuracy of sentinel lymph node biopsy using single photon emission computed tomography/computed tomography with 99mTc phytate to detect locoregional lymph node metastases in patients with papillary thyroid carcinoma

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