Sentinel lymph node in thyroid tumors – own experience

Kaczka, Krzysztof; Luks, Bartłomiej; Jasion, Jakub; Pomorski, Lech

doi:10.5114/wo.2013.34623

Cited by 10 publications

(9 citation statements)

References 51 publications

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“…A lower detection rate using the blue dye technique compared to the radiotracer has been reported in other malignancies (including thyroid cancer) too [15,27]. Considering the adverse reactions associated with blue dyes [28] and possible staining of parathyroid glands by blue dye [22,29], our results suggest that a radiotracer only technique would be sufficient for sentinel node mapping in thyroid cancer patients.…”

Section: Discussionmentioning

confidence: 80%

Mapowanie węzłów wartowniczych w raku brodawkowatym tarczycy z zastosowaniem radioznacznika i niebieskiego barwnika

Assadi¹,

Yarani²,

Jangjoo³

et al. 2014

Endokrynologia Polska

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Introduction: In the current study, we evaluated the accuracy of sentinel node mapping in thyroid cancer patients using both radiotracer and blue dye. Material and methods: 30 patients with a diagnosis of papillary thyroid carcinoma (PTC) were included in the study; 2-3 hours before surgery, 0.5 mCi 99m-Tc-Antimony Sulfide Colloid was injected intra-tumourally. 15 minutes post-injection, lymphoscintigraphy images of the neck were obtained. Immediately after anaesthesia induction, 0.5 mL patent blue V was also injected in the same fashion. Sentinel lymph nodes were detected intraoperatively using gamma probe and blue dye. Total thyroidectomy was performed for all patients with dissection of central neck lymph nodes as well as sampling of the lateral neck lymph nodes. Results: At least one sentinel node could be identified during surgery in 19 patients (63.3%). The median number of sentinel nodes per patient was 1. Sentinel nodes in 12 patients were pathologically involved. No false negative case was noted. Upstaging occurred in six patients (20%). Conclusions: Sentinel node mapping in papillary thyroid carcinoma is a feasible technique with high accuracy for the detection of lymph node involvement. This technique can guide surgeons to perform central lymph node dissection only in patients with pathologically involved sentinel nodes. Although SLN detection in the lateral neck lymph nodes increases the extension of lymphadenectomy, SLN mapping can result in upstaging in older patients (> 45 years of age) or treatment plan change in younger patients (< 45 years of age) by the detection of lateral lymph node involvement. (Endokrynol Pol 2014; 65 (4): 281-286)

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Section: Discussionmentioning

confidence: 80%

Mapowanie węzłów wartowniczych w raku brodawkowatym tarczycy z zastosowaniem radioznacznika i niebieskiego barwnika

Assadi¹,

Yarani²,

Jangjoo³

et al. 2014

Endokrynologia Polska

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“…Generally, the recommended treatment is total thyroidectomy with lymph node dissection, followed by radiotherapy [ 24 ]. Many clinicians offer sentinel and other lymph node biopsies for suspected differentiated thyroid cancer [ 25 ] to avoid unnecessary lymph node dissection. However, the entire SCC group had a 55% chance of a lymph node metastasis diagnosis in our study.…”

Section: Discussionmentioning

confidence: 99%

Less aggressive disease in patients with primary squamous cell carcinomas of the thyroid gland and coexisting lymphocytic thyroiditis

Aşık

Binnetoğlu

Şen

et al. 2015

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Aim of the studyPrimary squamous cell carcinoma (SCC) of the thyroid gland is extremely rare. Infrequently, primary SCC of the thyroid gland is accompanied by other thyroid diseases such as Hashimoto's thyroiditis (HT). Recently, studies have demonstrated that differentiated thyroid cancer with coexisting HT has a better prognosis. However, the prognosis of patients with primary SCC of the thyroid gland and coexistent HT has not been clearly identified. We compared the clinical characteristics and disease stages of patients with primary SCC with and without lymphocytic thyroiditis (LT).Material and methodsWe reviewed reports of primary SCC of the thyroid gland published in the English literature.Results and conclusionsWe identified 46 papers that included 17 cases of primary SCC of the thyroid gland with LT and 77 cases of primary SCC of the thyroid gland without LT. Lymph node metastasis and local invasion rates did not differ between these two groups. Distant metastases were absent in patients with LT, and were observed in 13 (16.9%) patients without LT. A greater proportion of patients without LT had advanced stage disease (stage IV A-B-C) than patients with LT (p < 0.05). Patients with primary SCC of the thyroid gland and coexisting LT had lower tumour-node-metastasis stage and frequency of distant metastasis than those without LT. Lymphocytic infiltration in patients with SCC appears to limit tumour growth and distant metastases.

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“…SLN detection rate in patients was 83.1% in the first group, 98.8% in the second group and 97.8% in the third group. In two studies of the third group, Catarci have shown better result of detection with radiocolloid relative to the vital dye (83.3% versus 50%), while Lee showed a better IR with vital dye (93% versus 88.4%) (24,25,26).…”

Section: Sentinel Node Detection In Patients With Thyroid Carcinoma: mentioning

confidence: 93%

Sentinel lymph node concept in differentiated thyroid cancer

Marković¹,

Džodić²

2014

SANAMED

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Introduction: Differentiated thyroid carcinoma (DTC) account up to 90% of all thyroid malignacies, and represents the most common malignant tumors of endocrine system. The incidence of papillary thyroid carcinoma (PTC), especially small tumors is rapidly increasing during past three decades. At the time of diagnosis, the incidence of lymph node metastases (LNM) ranges from 80 to 90%. During the last 15 years, LNM were recognized as bad prognostic factor for both local-regional relapse (LRR) and cancer specific survival. There is general agreement that neck dissections are indicated in cases of clinically apparent LNM. The subject of the current controversy is the surgical treatment of occult LNM that remain unrecognized on preoperative diagnosis (cN0). The extent of operations of the lymph nodes ranges from "wait and see" so-called "Western school" principle substantiated the role of applying ablative I131therapy and frequency peroperative complications (recurrent laryngeal nerve injury and hypoparathyroidism), especially for less experienced teams to mutual prophylactic dissection of the central and lateral compartments so-called "Japanese school" due to the limited use of radioactive iodine therapy and significantly lower operating morbidity if dissetion was done during primary operation. Despite high prevalence of occult LNM, existing controversies regarding diagnosis, longterm prognostic impact and extent of lymph node surgery, motivated some authors to apply consept of sentinel lymph node biopsy (SLNb) in DTC, taking into account excellent results of SLN concept in breast cancer and skin melanoma. This review presents the summarized results of relevant studies and three meta-analysis of accuracy and applicability of SLN concept in patients with differentiated thyroid carcinoma.

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Sentinel lymph node in thyroid tumors – own experience

Cited by 10 publications

References 51 publications

Mapowanie węzłów wartowniczych w raku brodawkowatym tarczycy z zastosowaniem radioznacznika i niebieskiego barwnika

Mapowanie węzłów wartowniczych w raku brodawkowatym tarczycy z zastosowaniem radioznacznika i niebieskiego barwnika

Less aggressive disease in patients with primary squamous cell carcinomas of the thyroid gland and coexisting lymphocytic thyroiditis

Sentinel lymph node concept in differentiated thyroid cancer

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