Mapowanie węzłów wartowniczych w raku brodawkowatym tarczycy z zastosowaniem radioznacznika i niebieskiego barwnika

Abstract

Introduction: In the current study, we evaluated the accuracy of sentinel node mapping in thyroid cancer patients using both radiotracer and blue dye. Material and methods: 30 patients with a diagnosis of papillary thyroid carcinoma (PTC) were included in the study; 2-3 hours before surgery, 0.5 mCi 99m-Tc-Antimony Sulfide Colloid was injected intra-tumourally. 15 minutes post-injection, lymphoscintigraphy images of the neck were obtained. Immediately after anaesthesia induction, 0.5 mL patent blue V was also injected in the same fashion. Sentinel lymph nodes were detected intraoperatively using gamma probe and blue dye. Total thyroidectomy was performed for all patients with dissection of central neck lymph nodes as well as sampling of the lateral neck lymph nodes. Results: At least one sentinel node could be identified during surgery in 19 patients (63.3%). The median number of sentinel nodes per patient was 1. Sentinel nodes in 12 patients were pathologically involved. No false negative case was noted. Upstaging occurred in six patients (20%). Conclusions: Sentinel node mapping in papillary thyroid carcinoma is a feasible technique with high accuracy for the detection of lymph node involvement. This technique can guide surgeons to perform central lymph node dissection only in patients with pathologically involved sentinel nodes. Although SLN detection in the lateral neck lymph nodes increases the extension of lymphadenectomy, SLN mapping can result in upstaging in older patients (> 45 years of age) or treatment plan change in younger patients (< 45 years of age) by the detection of lateral lymph node involvement. (Endokrynol Pol 2014; 65 (4): 281-286)

Sentinel Lymph Node Techniques in Urologic Oncology: Current Knowledge and Application

“…Therefore, SLNB mapping exhibits the highest accuracy in patients with MIBC at lower local advancement stages. This finding is in accordance with similar studies in other malignancies [118,119]. More recent studies have assessed SLN techniques in various clinical settings and concluded that they are feasible and safe in BCa, although their efficacy remains questionable [120][121][122].…”

Sentinel lymph node mapping: current applications and future perspectives in thyroid carcinoma

“…The SLN was identified in all cases, and the authors concluded that these techniques have a complementary role ( 74 ). Subsequently, other authors have evaluated this combination technique, for example, Lee et al ( 78 ), Huang et al ( 79 ), Assadi et al ( 80 ), and Gelmini et al ( 81 ).…”

Magnetic detection of sentinel lymph node in papillary thyroid carcinoma: The MAGIC-PAT study results

“…The concept of SLN is currently established in melanoma, vulvar and breast cancer patients, and it is being assessed in other types of solid tumours including differentiated thyroid carcinoma [14e16]. In thyroid cancer, SLN biopsy (SLNB) has been addressed using blue dyes [17,18], radioisotopes [4,19e22] or the combination of both [23]. The pooled detection rate of vital dyes is 15% lower than the rate for radioguided SLNB [24].…”