1998
DOI: 10.1023/a:1006895414925
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Abstract: Interest in creatine (Cr) as a nutritional supplement and ergogenic aid for athletes has surged over recent years. After cellular uptake, Cr is phosphorylated to phosphocreatine (PCr) by the creatine kinase (CK) reaction using ATP. At subcellular sites with high energy requirements, e.g. at the myofibrillar apparatus during muscle contraction, CK catalyzes the transphosphorylation of PCr to ADP to regenerate ATP, thus preventing a depletion of ATP levels. PCr is thus available as an immediate energy source, se… Show more

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Cited by 122 publications
(24 citation statements)
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“…Mitochondrial purification was assessed in parallel with an anti-COX antibody (C). The result clearly demonstrates that the ϳ55-and ϳ70-kDa CRTrelated proteins are both recognized by both the anti-N-terminal, as well as the anti-C-terminal, CRT antibodies (12) and that both of these immunoreactive polypeptides are predominantly localized in mitochondria of all tissues tested, where they are highly enriched relative to the total extracts.…”
Section: Intracellular Location Of Crt In Ratmentioning
confidence: 84%
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“…Mitochondrial purification was assessed in parallel with an anti-COX antibody (C). The result clearly demonstrates that the ϳ55-and ϳ70-kDa CRTrelated proteins are both recognized by both the anti-N-terminal, as well as the anti-C-terminal, CRT antibodies (12) and that both of these immunoreactive polypeptides are predominantly localized in mitochondria of all tissues tested, where they are highly enriched relative to the total extracts.…”
Section: Intracellular Location Of Crt In Ratmentioning
confidence: 84%
“…Male Wistar rats (250 -300 g) were purchased from Invitrogen BRL, (Fü llinsdorf, Switzerland). The characterization of our rabbit anti-CRT peptide antibodies has been described earlier (12).…”
Section: Methodsmentioning
confidence: 99%
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