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Abstract

Angiogenin is a member of the ribonuclease superfamily, which shows an ever expanding collection of molecules being identified and cloned. It was initially isolated from the conditioned medium of cultured tumour cells. Its angiogenic activity appears to be critical for the maintenance and support of tumour growth. Angiogenin also plays a role in a number of non-malignant vasculoproliferative pathological conditions. Along with other related molecules, it has been identified in a wide variety of somatic tissues in adult and embryonic stages of vertebrate development. This suggests that angiogenin and related molecules are likely to play a vital role in normal physiology. Angiogenin is detectable in serum and to date has been implicated as a mitogen for vascular endothelial cells, an immune modulator with suppressive effects on polymorphonuclear leukocytes, an activator of certain protease cascades such as matrix metalloproteases and plasminogen-activated plasmin pathways, as well as an adhesion molecule. However, the role of the angiogenin family in both normal and abnormal physiology and in development will only fully be realised by genetic approaches involving gene deletion.

Burn blister fluids in the neovascularization stage of burn wound healing: A comparison between superficial and deep partial-thickness burn wounds

“…[24] In contrast, a continuously high level of angiogenin expression in DPTB fluids, even at 4 days post injury, is consistent with the high demand for neovascularization in DPTB compared with SPTB wounds. [19] Therefore, differential angiogenin expression between SPTB and DPTB wound fluids implies the different healing processes of these wounds.…”

Crystallographic Studies on the Role of the C-Terminal Segment of Human Angiogenin in Defining Enzymatic Potency,

“…Substitutions by His, Ser, Ala, Glu, Asn, Lys, and Val increased the effectiveness of Ang toward tRNA by factors of 18,16,15,9,8,4, and 2, respectively (32,36). These findings were mysterious until the advent of the Ang crystal structure (28), which showed the side chain of Asp116 is oriented quite differently from that of Asp121 in RNase A.…”

The Inorganic Perspective of VEGF: Interactions of Cu2+ with Peptides Encompassing a Recognition Domain of the VEGF Receptor

“…A large number of angiogenic molecules have been identified which include members of the fibroblast growth factor family, epidermal growth, transforming growth factor-α and β, tumor necrosis factor-α, platelet-derived growth factor, Angiopoietin, Angiogenin, SPARC (secreted protein acidic and rich in cysteine), etc. [7][8][9][10][11][12].…”