Burn blister fluids in the neovascularization stage of burn wound healing: A comparison between superficial and deep partial-thickness burn wounds

Pan, Shiyan

doi:10.4103/2321-3868.113332

Cited by 19 publications

(15 citation statements)

References 30 publications

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“…Healing is expected within 2 weeks for SPTB and usually takes longer than 3 weeks for DPTB [10]. The periods of 12 and 17 days required, respectively, for complete reepithelialization of this patient’s wounds in the right upper limb and the left upper limb, suggest effectiveness of NTFS as a xenograft for the treatment of human burns.…”

Section: Discussionmentioning

confidence: 99%

Innovative treatment using tilapia skin as a xenograft for partial thickness burns after a gunpowder explosion

Lima-Júnior¹,

Filho

Costa

et al. 2019

Journal of Surgical Case Reports

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Tilapia skin has non-infectious microbiota, high amounts of type I collagen, and similar morphological structure to human skin, so it has been suggested as a potential xenograft for the management of burn wounds. A 23-year-old male patient, with no comorbidities, arrived at our burn treatment center after a thermal injury caused by contact with flames from a gunpowder explosion. Superficial partial thickness burns were present in his right upper limb and deep partial thickness burns were present in his left upper limb. Tilapia skin was applied to the lesions, leading to complete reepithelialization within 12 and 17 days of treatment, respectively. No dressing changes were needed and no side effects were observed. Tilapia skin carries the promise of an innovative, easy-to-apply and highly available product that can become the first nationally studied animal skin registered by the National Sanitary Surveillance Agency for use in the treatment of burns.

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Section: Discussionmentioning

confidence: 99%

Innovative treatment using tilapia skin as a xenograft for partial thickness burns after a gunpowder explosion

Lima-Júnior¹,

Filho

Costa

et al. 2019

Journal of Surgical Case Reports

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“…Recently, angiogenin has been demonstrated to be a key paracrine signaler in superficial and deep partial-thickness burns for the promotion of neovascularization. Pan et al demonstrated that angiogenin alone was able to induce CAC differentiation into ECs in the absence of VEGF-A, and that its absence was associated with a significant reduction in EC proliferation and new blood vessel formation in vivo [ 28 ].…”

Section: Reviewmentioning

confidence: 99%

Endothelial progenitor cells and burn injury – exploring the relationship

et al. 2016

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Burn wounds result in varying degrees of soft tissue damage that are typically graded clinically. Recently a key participant in neovascularization, the endothelial progenitor cell, has been the subject of intense cardiovascular research to explore whether it can serve as a biomarker for vascular injury. In this review, we examine the identity of the endothelial progenitor cell as well as the evidence that support its role as a key responder after burn insult. While there is conflicting evidence with regards to the delta of endothelial progenitor cell mobilization and burn severity, it is clear that they play an important role in wound healing. Systematic and controlled studies are needed to clarify this relationship, and whether this population can serve as a biomarker for burn severity.

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“…[1] Chronic wounds can be very complex which implies that they have their own field of specialty within medicine. [2,3] Wounds are usually treated with wound dressings, which have strict requirements in order to realize optimal wound healing including biocompatibility, the ability to provide a moist environment while removing excess exudate, being nonadhesive and easily removable and processable in different sizes. [4,5] Nowadays, other important factors are considered during wound management.…”

Section: Introductionmentioning

confidence: 99%

Activated Carbon Containing PEG‐Based Hydrogels as Novel Candidate Dressings for the Treatment of Malodorous Wounds

Minsart

Mignon

Arslan

et al. 2020

Macro Materials & Eng

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Malodorous wounds have a detrimental effect on the patient's well‐being. A dressing combining the properties of hydrogels and activated carbon (AC) would be beneficial for the treatment of these wounds, controlling wound exudate while adsorbing malodor‐causing compounds. The present work involves the use of acrylate‐endcapped, urethane‐based precursors (AUPs) and methacrylated alginate (AlgMOD). AUPs are synthesized with a varying poly(ethylene glycol) backbone molar mass (2–20 kg mol−1) to tune mechanical and swelling properties, whereas methacrylated alginate, known for its hemostatic properties, enables chemical cross‐linking. Blends of AUP and AlgMOD with AC are processed into hydrogel sheets and electrospun membranes. The results indicate tunable mechanical (Young's moduli 0.03–0.63 MPa) and swelling properties (2.2–34.9 gwater ) along with high gel fractions (>85%). The sheets are compared with commercial odor‐adsorbing dressings (Carbonet and Carboflex), enabling benchmarking. AUP sheets (8 and 10 kg mol−1) containing 0.5% w/w AC show strong adsorption (>90% after 24 h) of crystal violet. The obtained (core–shell AlgMOD/AUP) fibers are visualized using scanning and transmission electron microscopy. Indirect cell tests reveal the developed materials to be biocompatible. In conclusion, a hydrogel‐based odor‐adsorbing wound dressing is successfully synthesized and holds promise for malodorous wound healing.

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Burn blister fluids in the neovascularization stage of burn wound healing: A comparison between superficial and deep partial-thickness burn wounds

Cited by 19 publications

References 30 publications

Innovative treatment using tilapia skin as a xenograft for partial thickness burns after a gunpowder explosion

Innovative treatment using tilapia skin as a xenograft for partial thickness burns after a gunpowder explosion

Endothelial progenitor cells and burn injury – exploring the relationship

Activated Carbon Containing PEG‐Based Hydrogels as Novel Candidate Dressings for the Treatment of Malodorous Wounds

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