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Abstract

Androgens were the mainstay of treatment of renal anemia prior to the introduction of recombinant human erythropoietin. With the introduction of this recombinant hormone, the protocols of treatment of anemia were completely modified, and the use of androgens was relegated to the background. However, several authors have continued showing interest in the use of androgenic steroids for the treatment of anemia. This review examines several aspects of aging on androgenic hormones and hematopoiesis, the effects of androgen administration on hematological parameters, the side effects of these compounds and the future of this treatment for anemia in renal patients.

A Systems-Pharmacology Analysis of Herbal Medicines Used in Health Improvement Treatment: Predicting Potential New Drugs and Targets

“…In western medicine, androgen has been widely used as hematopoiesis reconstruction medicine in clinic [95], an increasing number of studies have indicated that androgen may be associated with undesired effects. Usual side effects have been reported mainly in adolescents, young men and women and are consist of flushing of the skin and acne, hirsutism, deepening and hoarseness of the voice, masculinization, amenorrhea and increase in libido [96]. We can disclose the action mechanisms from the network target viewpoint: BTH may regulate hemopoietic growth factor, bone marrow stromal cell and hematopoietic cell apoptosis process to against BDS-related hematopoietic abnormality processes.…”