Untitled

Antúnez-de-Mayolo, Gabriela; Antúnez-de-Mayolo, Adriana; Antunez-de-Mayolo, Pamela; Papiha, S. S.; Hammer, Michael P.; Yunis, Juan J.; Yunis, Emilio; Damodaran, Chendi; Pancorbo, Marian M. de; Caeiro, José Luis Blázquez; Puzyrev, V P; Herrera, René J.

doi:10.1002/1522-2683(200210)23:19<3346::aid-elps3346>3.0.co;2-j

Cited by 71 publications

(7 citation statements)

References 10 publications

(21 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…African populations appear completely distinct from the other populations. Similar results were obtained in previous studies using SNP loci, Alu insertion sites and D1S80 allele frequencies [86][87][88][89]. In these studies, the East Asian populations appear to be more distant from South Asian, European and Admixed American populations.…”

Section: Human Evolution and Geographic Distribution Of The Drug-respsupporting

confidence: 90%

See 1 more Smart Citation

Heterogeneity in the distribution of 159 drug-response related SNPs in world populations and their genetic relatedness

2020

View full text Add to dashboard Cite

Interethnic variability in drug response arises from genetic differences associated with drug metabolism, action and transport. These genetic variations can affect drug efficacy as well as cause adverse drug reactions (ADRs). We retrieved drug-response related single nucleotide polymorphism (SNP) associated data from databases and analyzed to elucidate population specific distribution of 159 drug-response related SNPs in twenty six populations belonging to five super-populations (African, Admixed Americans, East Asian, European and South Asian). Significant interpopulation differences exist in the minor (variant) allele frequencies (MAFs), linkage disequilibrium (LD) and haplotype distributions among these populations. 65 of the drug-response related alleles, which are considered as minor (variant) in global population, are present as the major alleles (frequency �0.5) in at least one or more populations. Populations that belong to the same super-population have similar distribution pattern for majority of the variant alleles. These drug response related variant allele frequencies and their pairwise LD measure (r 2) can clearly distinguish the populations in a way that correspond to the known evolutionary history of human and current geographic distributions, while D' cannot. The data presented here may aid in identifying drugs that are more appropriate and/or require pharmacogenetic testing in these populations. Our findings emphasize on the importance of distinct, ethnicity-specific clinical guidelines, especially for the African populations, to avoid ADRs and ensure effective drug treatment.

show abstract

Section: Human Evolution and Geographic Distribution Of The Drug-respsupporting

confidence: 90%

“…Multiple studies have used allele frequencies for inferring human population structure [86][87][88]. We used the MAFs and pairwise LD measures (r 2 and D') of 159 drug response-related SNPs for multivariate analysis using PCA, PLS-DA and hierarchical clustering (Figs 3 and 4).…”

Section: Human Evolution and Geographic Distribution Of The Drug-respmentioning

confidence: 99%

Heterogeneity in the distribution of 159 drug-response related SNPs in world populations and their genetic relatedness

2020

View full text Add to dashboard Cite

show abstract

“…37 (DYS19, DYS389 I, DYS389 II, DYS390, DYS391, DYS392, and DYS393) for R1a1 and six loci (DYS389 I, DYS389 II, DYS390, DYS391, DYS392, and DYS393) for N1c1-and N1b-derived samples given the limited number of loci reported for the previously published reference populations (Supplementary Table 1). Haplotype expansion times were defined using the programs NETWORK 4.2.00 and BATWING, assuming an average Y-STR mutation rate of 6.9 Â 10…”

Section: Methodsmentioning

confidence: 99%

Y-Chromosome distribution within the geo-linguistic landscape of northwestern Russia

et al. 2009

View full text Add to dashboard Cite

Populations of northeastern Europe and the Uralic mountain range are found in close geographic proximity, but they have been subject to different demographic histories. The current study attempts to better understand the genetic paternal relationships of ethnic groups residing in these regions. We have performed high-resolution haplotyping of 236 Y-chromosomes from populations in northwestern Russia and the Uralic mountains, and compared them to relevant previously published data. Haplotype variation and age estimation analyses using 15 Y-STR loci were conducted for samples within the N1b, N1c1 and R1a1 single-nucleotide polymorphism backgrounds. Our results suggest that although most genetic relationships throughout Eurasia are dependent on geographic proximity, members of the Uralic and Slavic linguistic families and subfamilies, yield significant correlations at both levels of comparison making it difficult to denote either linguistics or geographic proximity as the basis for their genetic substrata. Expansion times for haplogroup R1a1 date approximately to 18 000 YBP, and age estimates along with Network topology of populations found at opposite poles of its range (Eastern Europe and South Asia) indicate that two separate haplotypic foci exist within this haplogroup. Data based on haplogroup N1b challenge earlier findings and suggest that the mutation may have occurred in the Uralic range rather than in Siberia and much earlier than has been proposed (12.9±4.1 instead of 5.2±2.7 kya). In addition, age and variance estimates for haplogroup N1c1 suggest that populations from the western Urals may have been genetically influenced by a dispersal from northeastern Europe (eg, eastern Slavs) rather than the converse.

show abstract

“…The neighbour joining tree was constructed based on the DA matrix (Saitou and Nei, 1987). In order to determine the population clustering of the populations studied, principal coordinate analysis was carried out using available data on world populations (Stoneking et al, 1997;Majumder et al, 1999;Mukherjee et al, 2000;Nasidze et al, 2001;Antunez-de-Mayolo et al, 2002;Vishwanathan et al, 2003;Comas et al, 2004;Saraswathy et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Genetic sketch of the six population groups of Rajasthan: a study based on 12 autosomal loci

Dada

Saraswathy

Meitei

et al. 2011

View full text Add to dashboard Cite

Rajasthan lies on the northwest border of India, and has acted as a major route for human movements since prehistoric and historic times. The present study was conducted to gain an insight into inter-and intrapopulation affinities or variations among the six population groups of Rajasthan. DNA samples from 221 unrelated individuals belonging to six endogamous population groups of Rajasthan, including both tribal (Bhil, Damaria, Garasia, Mina and Saharia) and caste populations (Rajput) were screened for 12 DNA (seven Alu indel and five RFLP) markers. All the loci were found to be polymorphic in all the studied populations. The G ST values which determine the genetic differentiation between the population ranges from 1.5% in LPL to 8.7% in APO. This study suggests that the population groups of Rajasthan are genetically close to other Indian populations, reflecting a common genetic unity among the Indian populations. The study also indicates European gene flow into the populations studied in this paper.

show abstract

Untitled

Cited by 71 publications

References 10 publications

Heterogeneity in the distribution of 159 drug-response related SNPs in world populations and their genetic relatedness

Heterogeneity in the distribution of 159 drug-response related SNPs in world populations and their genetic relatedness

Y-Chromosome distribution within the geo-linguistic landscape of northwestern Russia

Genetic sketch of the six population groups of Rajasthan: a study based on 12 autosomal loci

Contact Info

Product

Resources

About