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Páez, J. M. García; Jorge, Eduardo; Rocha, A.; Castillo‐Olivares, J. L.; Millán, Isabel; Carrera, A.; Cordón, A.; Téllez, Gabriel; Burgos, R.

doi:10.1023/a:1014710504963

Cited by 10 publications

(7 citation statements)

References 19 publications

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“…The strength measured here (standard deviation in parentheses) of 19.1 ( σ = 2.2) MPa for adult and 32.9 ( σ = 4.1) MPa for neonatal pericardium is less than that reported previously for unfixed bovine pericardium of 25–29 MPa and of unfixed porcine pericardium of 22-23 MPa [37, 38] but greater than that reported in a different study for calf pericardium at 6–9 months of 11.5 ± 4.6 MPa [39]. We report the ultimate tensile strength as a modulus, that is, tissue property per cross-sectional area.…”

Section: Resultscontrasting

confidence: 70%

Age Dependent Differences in Collagen Alignment of Glutaraldehyde Fixed Bovine Pericardium

Sizeland

Wells

Higgins

et al. 2014

BioMed Research International

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Bovine pericardium is used for heart valve leaflet replacement where the strength and thinness are critical properties. Pericardium from neonatal animals (4–7 days old) is advantageously thinner and is considered as an alternative to that from adult animals. Here, the structures of adult and neonatal bovine pericardium tissues fixed with glutaraldehyde are characterized by synchrotron-based small angle X-ray scattering (SAXS) and compared with the mechanical properties of these materials. Significant differences are observed between adult and neonatal tissue. The glutaraldehyde fixed neonatal tissue has a higher modulus of elasticity (83.7 MPa) than adult pericardium (33.5 MPa) and a higher normalised ultimate tensile strength (32.9 MPa) than adult pericardium (19.1 MPa). Measured edge on to the tissue, the collagen in neonatal pericardium is significantly more aligned (orientation index (OI) 0.78) than that in adult pericardium (OI 0.62). There is no difference in the fibril diameter between neonatal and adult pericardium. It is shown that high alignment in the plane of the tissue provides the mechanism for the increased strength of the neonatal material. The superior strength of neonatal compared with adult tissue supports the use of neonatal bovine pericardium in heterografts.

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Section: Resultscontrasting

confidence: 70%

Age Dependent Differences in Collagen Alignment of Glutaraldehyde Fixed Bovine Pericardium

Sizeland

Wells

Higgins

et al. 2014

BioMed Research International

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“…Garcia Páez et. al investigated and compared the mechanical properties of GL-treated BP and PP tissues between 2001 and 2003 through the use of a hydraulic simulator, as well as uniaxial and biaxial loading [12, 13, 15, 31]. However, the biaxial testing conducted in these papers differs from the biaxial testing conducted in this study, resembling a membrane inflation test, in addition to lacking the multi-protocol aspect of the biaxial trials performed by our group.…”

Section: Discussionmentioning

confidence: 92%

“…BP and PP mechanical properties have been shown to differ as a result of the intrinsic tissue structural variability, selection and mounting of the samples into the testing device and/or due to altered treatment and testing protocols [12, 13, 15, 29–31]. Garcia Páez et.…”

Section: Discussionmentioning

confidence: 99%

“…Although the mechanical properties of GL-treated BP tissue have been previously characterized through biaxial and uniaxial testing [9–14], the mechanical properties of BP and PP tissues have been compared primarily through uniaxial testing [11–13, 15]. To the authors’ knowledge, the only published study that has compared the mechanical response of younger, thinner BP with thicker, older BP tissue was performed by Sizeland et al [5] through uniaxial testing.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of transcatheter heart valve biomaterials: Biomechanical characterization of bovine and porcine pericardium

Caballero

Sulejmani

Martin

et al. 2017

Journal of the Mechanical Behavior of Biomedical Materials

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Objective Bovine pericardium (BP) has been identified as a choice biomaterial for the development of surgical bioprosthetic heart valves (BHV) and transcatheter aortic valves (TAV). Porcine pericardium (PP) and younger BP have been suggested as candidates TAV leaflet biomaterials for smaller-profile devices due to their reduced thickness; however, their mechanical and structural properties remain to be fully characterized. This study characterized the material properties of chemically treated thick (PPK) and thin (PPN) PP, as well as fetal (FBP), calf (CBP) and adult (ABP) BP tissues in order to better understand their mechanical behavior. Methods Planar biaxial testing and uniaxial failure testing methods were employed to quantify tissue mechanical responses and failure properties. Fiber characteristics were examined using histological analysis. Results ABP and CBP tissues were significantly stiffer and stronger than the younger FBP tissues. Histological analysis revealed a significantly larger concentration of thin immature collagen fibers in the FBP tissues than in the ABP and CBP tissues. While PP tissues were thinnest, they were stiffer and less extensible than the BP tissues. Conclusions Due to comparable mechanical properties but significantly reduced thickness, CBP tissue may be a more suitable material for TAV manufacturing than ABP tissue. FBP tissue, despite its reduced thickness and higher flexibility, was weaker and should be studied in more detail. Although PP tissues are the thinnest, they were least extensible and failed at earlier strain than BP tissues. The differences between PP and BP tissues should be further investigated and suggest that they should not be used interchangeably in the manufacturing of TAV.

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“…The mechanical properties of glutaraldehyde-treated BP and PP, have been investigated and characterized primarily through uniaxial and biaxial tensile tests (3, 20–27), which are both planar tests. Studies on the out-of-plane, flexural behavior of pericardia are limited (28, 29) despite the critical role leaflet bending plays in bioprosthetic heart valve function and durability (30).…”

Section: Introductionmentioning

confidence: 99%

Characterization of mechanical properties of pericardium tissue using planar biaxial tension and flexural deformation

Murdock

Martin

Sun

2018

Journal of the Mechanical Behavior of Biomedical Materials

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Flexure is an important mode of deformation for native and bioprosthetic heart valves. However, mechanical characterization of bioprosthetic leaflet materials has been done primarily through planar tensile testing. In this study, an integrated experimental and computational cantilever beam bending test was performed to characterize the flexural properties of glutaraldehyde-treated bovine and porcine pericardium of different thicknesses. A strain-invariant based structural constitutive model was used to model the pericardial mechanical behavior quantified through the bending tests of this study and the planar biaxial tests previously performed. The model parameters were optimized through an inverse finite element (FE) procedure in order to describe both sets of experimental data. The optimized material properties were implemented in FE simulations of transcatheter aortic valve (TAV) deformation. It was observed that porcine pericardium TAV leaflets experienced significantly more flexure than bovine when subjected to opening pressurization, and that the flexure may be overestimated using a constitutive model derived from purely planar tensile experimental data. Thus, modeling of a combination of flexural and biaxial tensile testing data may be necessary to more accurately describe the mechanical properties of pericardium, and to computationally investigate bioprosthetic leaflet function and design.

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Untitled

Cited by 10 publications

References 19 publications

Age Dependent Differences in Collagen Alignment of Glutaraldehyde Fixed Bovine Pericardium

Age Dependent Differences in Collagen Alignment of Glutaraldehyde Fixed Bovine Pericardium

Evaluation of transcatheter heart valve biomaterials: Biomechanical characterization of bovine and porcine pericardium

Characterization of mechanical properties of pericardium tissue using planar biaxial tension and flexural deformation

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