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Abstract

To date, there are no clear guide lines for the treatment of LELCB. Treatments performed include both deep transurethral resection of the tumor (TUR-B) as well as partial or radical cystectomy, with or without adjuvant treatments including systemic chemotherapy and radiotherapy. The prognosis is favorable for patients presenting with the pure and predominant forms with a diploid DNA pattern and very poor for patients presenting with focal LELCB. Bladder salvage therapy by performing both TUR-B alone or combined with adjuvant systemic chemotherapy may be a reasonable option for patients with pure or predominant LELCB, while radical surgery with adjuvant systemic therapy may be indicated for focal muscle invasive LELCB.

Lymphoepithelioma-like carcinoma of the urinary bladder: report of a rare case

“…Though uncommon, the tumor may have accompanying adenocarcinoma and squamous cell carcinoma as well 58. The overlying or adjacent urothelium may show urothelial dysplasia or carcinoma in situ 28. The present case was a pure LELC.…”

“…Since then there have been only a few relatively small studies on LELC of urinary bladder 2–8. The largest study was reported by Tamas et al8 who described 17 pure 13 mixed LELC.…”

“…Epstein-Barr virus (EBV) is frequently associated with lymphoepithelioma of the nasopharynx and LELC arising in the lung, stomach, thymus and salivary gland 1289. However, such an association has not been documented for LELC of the urinary bladder.…”

“…Carcinomas with similar histologic features arising outside the nasopharynx are called lymphoepithelioma-like carcinoma (LELC), which are reported in various organs such as the thymus, salivary gland, and cervix. Involvement of the urinary bladder, first reported by Zuckerberg et al in 1991,1 is uncommon, with a reported incidence between 0.4% and 1.3% of all bladder carcinomas 2. The tumor can occur either in pure form or in association With conventional urothelial carcinoma 3.…”

“…The tumor can occur either in pure form or in association With conventional urothelial carcinoma 3. The pure form is considered to have a better prognosis and exhibits a good response to chemotherapy 2–5. It is important to differentiate LELC from non-Hodgkin lymphoma, poorly differentiated invasive transitional cell carcinoma and poorly differentiated squamous cell carcinoma with lymphoplasmacytic infiltrate in the background.…”