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Ehlers, Bernhard; Goltz, Michael; Ejercito, Michael P.; Dasika, Gopal K.; Letchworth, Geoffrey J.

doi:10.1023/a:1008184630066

Cited by 18 publications

(2 citation statements)

References 26 publications

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“…Послідовність ДНК-полімерази (UL30), це великий ген поряд із раніше ідентифікованим консервативним кластером і глікопротеїном G(US4), віддаленим від кластера настільки це можливо для циркулярного геному, підтверджує тісний зв'язок між BoHV-2 і сімплексвірусами приматів, що говорить про щільні еволюційні відносини. Дослідники навіть вказували про те, що BoHV-2 може становити більшу небезпеку для людей, ніж це вважалось раніше (Ehlers, Goltz, Ejercito, Dasika, & Letchwotth, 1999).…”

Section: результати дослідженьunclassified

Herpesvirus mamilit of cattle

Moroz¹,

Expertise²,

Kornienko³

et al. 2021

VSTFH

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Herpesvirus mamilit in cattle is a viral disease characterized by vesicular, erosive and necrotic lesions of the skin of the nipples and udder. Currently, there are two forms of this disease, PSLD (pseudo-lumpy skin disease) and BHM (bovine herpetic mamilit).The first report on the isolation of herpesvirus from cattle with dermatitis (strain Allerton) dates back to 1957, when in South Africa diseases were observed among cows with lumpy dermatitis with ulcerative damage to the skin of the udder nipples. Later, in the 60s of the last century, there were reports of cases of ulcerative mamilitis of viral etiology among cows in Bulgaria, Australia and in the countries of South Africa -Rwanda and Tanzania. In all cases of herpesvirus mamilitis, the causative agent of the disease was identified as herpesvirus of the 2nd serotype. The herpesvirus etiology of the disease was also laboratory confirmed in the Netherlands, Switzerland, Ireland, Germany and the Czech Republic.In Ukraine, the first report of herpesvirus mamilitis of cattle (ulcerative mamilitis of cows) appeared only in 2003, although diseases with similar clinical signs were known earlier.Infection of dairy cattle can significantly affect productivity (decrease by about 20 %), chronic mastitis arising from this disease leads to a decrease in the number of productive animals. Natural infection caused by BoHV-2 occurs mainly in heifers and first lactation cows. Calving can be a factor in the reactivation of the virus. The natural transmission mechanism of the BoHV-2 virus is not fully understood. Most people talk about mechanical transmission through milking machines, through attendants, through the bites of Stomoxys calcitrans flies. The intact nipple skin is resistant to the penetration of the virus, which proves once again that any nipple injury is preceded by an infection.Serological studies show that the virus is common in livestock throughout the world. According to clinical signs, it is rather difficult to differentiate this disease from other viral diseases (viral diarrhea, malignant catarrhal fever, parapoxviruses, infectious rhinotracheitis in cattle). The specialist literature describes the treatment of BoHV-2 disease in cows. The authors used Intacef for injection (Intas pharma, 3 g i / m), anistamine for injection (10 ml i / m), Melonex (10 ml i / m). Udder ulcers were treated with povidone-iodine ointment twice daily for 5 days. On the 5th day of treatment, the animals recovered.Vaccines for specific prevention of this disease have not been developed. Sick animals are separated (if possible) from the general herd and treated. Clinically affected animals are milked last. The udders and teats should be disinfected to reduce the spread of the virus. It is imperative to disinfect the milking machines and hands after each cow and after milking. The udder skin should be monitored to prevent mastitis.The widespread spread of this disease among productive animals, significant economic losses in the form of reduced milk yield and treatment costs, and the d...

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Section: результати дослідженьunclassified

Herpesvirus mamilit of cattle

Moroz¹,

Expertise²,

Kornienko³

et al. 2021

VSTFH

View full text Add to dashboard Cite

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“…These reports strongly suggest that BoHV-2 may not be limited to ruminants, a situation very similar to that described for BoHV-1. BoHV-2 was long considered most closely related to HSV-1 (49), and the close phylogenetic relationship of BoHV-2 to primate simplexviruses suggests these viruses could have zoonotic potential (50).…”

Section: Ruminant Virusesmentioning

confidence: 99%

How Host Specific Are Herpesviruses? Lessons from Herpesviruses Infecting Wild and Endangered Mammals

et al. 2018

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Herpesviruses are ubiquitous and can cause disease in all classes of vertebrates but also in animals of lower taxa, including molluscs. It is generally accepted that herpesviruses are primarily species specific, although a species can be infected by different herpesviruses. Species specificity is thought to result from host-virus coevolutionary processes over the long term. Even with this general concept in mind, investigators have recognized interspecies transmission of several members of the Herpesviridae family, often with fatal outcomes in non-definitive hosts-that is, animals that have no or only a limited role in virus transmission. We here summarize herpesvirus infections in wild mammals that in many cases are endangered, in both natural and captive settings. Some infections result from herpesviruses that are endemic in the species that is primarily affected, and some result from herpesviruses that cause fatal disease after infection of non-definitive hosts. We discuss the challenges of such infections in several endangered species in the absence of efficient immunization or therapeutic options.

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DNA polymerase gene locus of Cercopithecine herpesvirus 1 is a suitable target for specific and rapid identification of viral infection by PCR technology

2005

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The family Herpesviridae comprises at least 100 herpesviruses. Numerous human and animal pathogenic herpesviruses have been identified so far, including Cercopithecine herpesvirus 1 (CeHV-1). This virus is a member of the subfamily Alphaherpesvirinae and is the most hazardous herpesvirus to man. CeHV-1 is also known as B-virus or monkey B virus and as Herpesvirus simiae. In order to gain more genetic information, the viral DNA polymerase (DPOL) gene was identified using polymerase chain reaction (PCR) and DNA nucleotide sequence analysis. The deduced amino acid sequence contains the motifs and signatures that are typical for the B-family of DPOLs. The DPOL gene of CeHV-1 was found to be a suitable target for the specific and rapid identification of the Cercopithecine herpesvirus 1 infection by PCR technology. Comparative analysis of the DNA sequences of the DPOL gene loci of CeHV-1, Human herpesvirus 1 and 2 (HHV-1 and HHV-2), and other herpesviruses was carried out for determination of unique genomic regions of the individual DPOL genes. A primer set of 12 primers was used for screening the DNA of CeHV-1, HHV-1, and HHV-2 by detailed PCR. It was found that six out of twelve primer combinations are able to detect specifically the CeHV-1 genome without cross reactivity with the genome of HHV-1 and/or HHV-2. The specificity of the individual amplified DNA fragments was confirmed by DNA nucleotide sequence analysis. The results of these studies indicate that the six primer combinations of the specific CeHV-1 DPOL primer set is the method of choice for a rapid, precise and specific identification of a CeHV-1 infection by PCR. Due to the fact that this specific CeHV-1 DPOL primer set does not amplify any DNAs of HHV-1 or HHV-2 genome this technology is stressing and can be successfully used unlimited and more credible in all laboratories with PCR technical facility routinely for detection of a CeHV-1 infection in vivo or in vitro.

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Cited by 18 publications

References 26 publications

Herpesvirus mamilit of cattle

Herpesvirus mamilit of cattle

How Host Specific Are Herpesviruses? Lessons from Herpesviruses Infecting Wild and Endangered Mammals

DNA polymerase gene locus of Cercopithecine herpesvirus 1 is a suitable target for specific and rapid identification of viral infection by PCR technology

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