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Abstract

Monosodium glutamate (MSG) is one of additive compounds that can easily cross the placenta and affect brain development. The current study aims to investigate the detrimental effects of monosodium glutamate (MSG) on Albino Swiss Mice Mus musculus fetal brain during pregnancy and after delivery. Forty-eight pregnant mice were divided into two groups: control group(24) received only distilled water while the second group (treated group 24 mice) received 0.2ml/daily of MSG solution from the 17th days of pregnancy until the 21st days after birth (lactation period). Infant mice were randomly selected from each group and sacrificed in 15th, 21st, 30th and 60th days after birth. Histopathological examination of brain showed significant differences between treated and control groups. Histological lesions including: megakaryocyte, necrosis, blood capillary stenosis, fraction of nerve fiber and blood capillary collapsing, eosinophil cell, medullary necrosis and necrosis, eosinophilic nerve fiber, horseshoe shape nucleus, rosette shape pattern, acidophilic cytoplasm, swelling cell, gliosis, coalesces and occluded blood vessel. In conclusion, monosodium glutamate has clear histological effects on the brain of infant mice.

Early and Sustained Inflammatory State Induces Muscle Changes and Establishes Obesogenic Characteristics in Wistar Rats Exposed to MSG-Induced Obesity Model

“…The model of obesity induced by perinatal injections of monosodium glutamate is widely studied and known in the literature [1][2][3]. The main alteration determined in this model is the damage and cell death of neurons in the hypothalamic nuclei, mainly in the arcuate nucleus (ARC), where this neuronal loss impairs the signalling mediated by insulin and affects the energy balance of the organism [3][4][5][6].…”