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Pecora, R.

doi:10.1023/a:1010067107182

Cited by 521 publications

(217 citation statements)

References 38 publications

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“…These discrepancies can be attributed to two factors: (1) the assumption in DLS that the particles in dispersion are spherical, and (2) as more biomolecule is added to the nanoparticle, the refractive index properties of the dispersing medium change. 22 Given that DLS is an intensity-based measurement system, this can cause errors in the particle size measurement. [22][23][24] Characterizing the number of protein layers present on a nanoparticle is important for researchers performing layer-by-layer assemblies such as designing tunable vehicles for drug delivery devices.…”

Section: E Comparing Psd With Theoretical Predictionsmentioning

confidence: 99%

“…22 Given that DLS is an intensity-based measurement system, this can cause errors in the particle size measurement. [22][23][24] Characterizing the number of protein layers present on a nanoparticle is important for researchers performing layer-by-layer assemblies such as designing tunable vehicles for drug delivery devices. 6,56 Because NHS chemistry was used to covalently bind protein to the bare gold nanoparticle surface, it is expected that only one protein layer should be present on the particle surface.…”

Section: E Comparing Psd With Theoretical Predictionsmentioning

confidence: 99%

“…Of these techniques, DLS is the most commonly used, 22 measuring particles from the micrometer range down to sub-nanometer sizes. 23 For accurate measurements, this well-established method 24 requires information from the user such as refractive index (RI) and absorption coefficient of the particles along with temperature and viscosity of the fluid medium.…”

Section: Introductionmentioning

confidence: 99%

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Physical characterization of nanoparticle size and surface modification using particle scattering diffusometry

Clayton¹,

Salameh

Wereley³

et al. 2016

Biomicrofluidics

281

166

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As the field of colloidal science continues to expand, tools for rapid and accurate physiochemical characterization of colloidal particles will become increasingly important. Here, we present Particle Scattering Diffusometry (PSD), a method that utilizes dark field microscopy and the principles of particle image velocimetry to measure the diffusivity of particles undergoing Brownian motion. PSD measures the diffusion coefficient of particles as small as 30 nm in diameter and is used to characterize changes in particle size and distribution as a function of small, labelfree, surface modifications of particles. We demonstrate the rapid sizing of particles using three orders-of-magnitude less sample volume than current standard techniques and use PSD to quantify particle uniformity. Furthermore, PSD is sensitive enough to detect biomolecular surface modifications of nanometer thickness. With these capabilities, PSD can reliably aid in a wide variety of applications, including colloid sizing, particle corona characterization, protein footprinting, and quantifying biomolecule activity. Published by AIP Publishing. [http://dx

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Section: E Comparing Psd With Theoretical Predictionsmentioning

confidence: 99%

Section: E Comparing Psd With Theoretical Predictionsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Physical characterization of nanoparticle size and surface modification using particle scattering diffusometry

Clayton¹,

Salameh

Wereley³

et al. 2016

Biomicrofluidics

281

166

View full text Add to dashboard Cite

show abstract

“…-This is usually determined using a particle size analyzer applying the principle of dynamic light scattering (DLS) (also known as photon correlation spectroscopy, PCS) (51)(52)(53)(54)(55)(56)(57)(58)(59). With the help of the autocorrelation function, PCS correlates the intensity variation of scattered light to particle size (60). PCS/DLS measures the hydrodynamic diameter, i.e., it considers all the particles under measurement as spherical.…”

Section: Characterization Of Nanospongesmentioning

confidence: 99%

Cyclodextrin based nanosponges for pharmaceutical use: A review

Tejashri¹,

Amrita²,

Darshana³

2013

Acta Pharmaceutica

197

100

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Nanosponges are a novel class of hyper-crosslinked polymer based colloidal structures consisting of solid nanoparticles with colloidal sizes and nanosized cavities. Well--known examples of nanosponges are titanium-based nanosponges (1), silicon nano- Nanosponges are a novel class of hyper-crosslinked polymer based colloidal structures consisting of solid nanoparticles with colloidal sizes and nanosized cavities. These nano-sized colloidal carriers have been recently developed and proposed for drug delivery, since their use can solubilize poorly water-soluble drugs and provide prolonged release as well as improve a drug's bioavailability by modifying the pharmacokinetic parameters of actives. Development of nanosponges as drug delivery systems, with special reference to cyclodextrin based nanosponges, is presented in this article. In the current review, attempts have been made to illustrate the features of cyclodextrin based nanosponges and their applications in pharmaceutical formulations. Special emphasis has been placed on discussing the methods of preparation, characterization techniques and applications of these novel drug delivery carriers for therapeutic purposes. Nanosponges can be referred to as solid porous particles having a capacity to load drugs and other actives into their nanocavity; they can be formulated as oral, parenteral, topical or inhalation dosage forms. Nanosponges offer high drug loading compared to other nanocarriers and are thus suitable for solving issues related to stability, solubility and delayed release of actives. Controlled release of the loaded actives and solubility enhancement of poorly water-soluble drugs are major advantages of nanosponge drug delivery systems.

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“…Dynamic light scattering techniques, such as PCS, are a common tool to study size distributions in situ (Pecora 2000). These studies render the hydrodynamic diameter distribution of the protein-nanoparticle ensemble.…”

Section: Pcs Experimentsmentioning

confidence: 99%

Influence of morphology in the catalytic activity of bioconjugated platinum nanostructures

et al. 2010

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Platinum nanoparticles stabilized by a protein, bovine serum albumin, have been synthesized successfully with two different morphologies such as cuboctahedra and nanorods. They have been characterized by the use of different techniques such as XPS, PCS, TEM, and STEM-HAADF. These nanoparticles have been applied as catalysts for the hydrogenation of allyl alcohol in an aqueous solution. A key finding of this article is the superior catalytic activity of the nanorods compared to the cuboctahedral particles. This difference in the catalytic activity was justified because of the variation in the amount of protein to stabilize the nanorods. A model for the nanorods and equations that describe the proportion of atoms in the different sites of the particle (face, vertex, edge, or interior) is used to calculate the percentage of atoms that are located on the nanorod surface. The stability of these particles as catalysts was also studied. The results showed that Pt nanorods and Pt cuboctahedra particles were degraded after 24 h of reaction.

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Cited by 521 publications

References 38 publications

Physical characterization of nanoparticle size and surface modification using particle scattering diffusometry

Physical characterization of nanoparticle size and surface modification using particle scattering diffusometry

Cyclodextrin based nanosponges for pharmaceutical use: A review

Influence of morphology in the catalytic activity of bioconjugated platinum nanostructures

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