Untitled

Abstract

The results of solubilization capacity examination, hemolysis testing, and cytostatic activity suggest that LCC may be useful as a carrier of taxol.

Chitosan derivatives obtained by chemical modifications for biomedical and environmental applications

“…N-Lauryl carboxymethyl chitosan with both hydrophobic and hydrophilic groups was studied in connection with the delivery of taxol to cancerous tissues [113]. Other examples are related to the production of polymeric vesicles for encapsulation of hydrophobic compounds like bleomycin [114].…”

Non‐Covalent Interactions in Polysaccharide Systems

“…It has been shown that these hydrophobic domains are able to adsorb hydrophobic substances such as taxol or B 2 vitamin and behave as a reservoir for controlled drug release. [15,16] Another important characteristic of amphiphilic polymers is their interfacial activity. It has been shown that alkylated chitosan moderately decreases the air/water and oil/water interfacial tension but the effect increases with alkyl chain length, as shown previously.…”

Spontaneous association of hydrophobized dextran and poly-β-cyclodextrin into nanoassemblies.

“…For instance, cholesteryl-bearing pullulans that can selfassemble to form nanoparticles and associate with various small hydrophobic molecules or proteins [13][14][15][16] were proposed as potential drug carriers [17]. Many studies also reported that aggregates formed of hydrophobized polysaccharides were able to solubilize poorly water-soluble drugs entrapped into their hydrophobic microdomains [18][19][20][21]. Moreover, the physicochemical and biochemical stability of these drugs appeared significantly increased when they were associated to these hydrophobized polysaccharides [22,23].…”