Spontaneous association of hydrophobized dextran and poly-β-cyclodextrin into nanoassemblies.

Daoud-Mahammed, Samia; Ringard-Lefebvre, Catherine; Razzouq, N.; Rosilio, Véronique; Gillet, Brigitte; Couvreur, P.; Amiel, Catherine; Gref, Ruxandra

doi:10.1016/j.jcis.2006.10.072

Cited by 86 publications

(75 citation statements)

References 51 publications

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“…Indeed, it was reported that nanogels with the same size form whatever was the manner of mixing the two polymer solutions: order of introduction of the solutions of modified dextran and poly(beta-cyclodextrin), method of mixing, temperature, etc….It seems that the simple diffusion of one solution in the other is sufficient to form the nanogels (164). The production yields can reach 95% of the incorporation of the solubilised polymer in the nanogels, showing the remarkable efficiency of the polymer association phenomena.…”

Section: Formation Of Nanoparticles From Neutral Nanogelsmentioning

confidence: 99%

Methods for the Preparation and Manufacture of Polymeric Nanoparticles

2008

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This review summarizes the different methods of preparation of polymer nanoparticles including nanospheres and nanocapsules. The first part summarizes the basic principle of each method of nanoparticle preparation. It presents the most recent innovations and progresses obtained over the last decade and which were not included in previous reviews on the subject. Strategies for the obtaining of nanoparticles with controlled in vivo fate are described in the second part of the review. A paragraph summarizing scaling up of nanoparticle production and presenting corresponding pilot set-up is considered in the third part of the review. Treatments of nanoparticles, applied after the synthesis, are described in the next part including purification, sterilization, lyophilization and concentration. Finally, methods to obtain labelled nanoparticles for in vitro and in vivo investigations are described in the last part of this review.

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Section: Formation Of Nanoparticles From Neutral Nanogelsmentioning

confidence: 99%

Methods for the Preparation and Manufacture of Polymeric Nanoparticles

2008

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“…[33,34] Moreover, analysis of the phase diagrams showed that increasing the number of links between the two polymers (by increasing the alkyl grafting ratio) led to a more concentrated polymer rich phase. [34] The nanoassemblies formed by mixing bCD polymer and hydrophobically modified dextran at low concentration in pure water (0.5-2 g Á L À1 ) [21,22,24] also result from associative phase separation. The cohesion of these structures is due to the establishment of numerous inclusion complexes between the alkyl groups and the bCD cavities acting as physical crosslinks between the chains of the two polymers.…”

Section: Guestmentioning

confidence: 99%

“…Regarding the good properties of biocompatibility and low toxicity of these nanoassemblies, promising drug delivery applications were considered. [21][22][23] Encapsulation of lipophilic drugs such as tamoxifen or benzophenone could be achieved by their inclusion complex formation with the free bCD cavities of the system. In these first studies, well defined dispersion of nanoassemblies (200 nm) could be obtained under defined conditions and concentration regimes.…”

Section: Introductionmentioning

confidence: 99%

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Size‐Controlled Nanoassemblies Based on Cyclodextrin‐Modified Dextrans

Wintgens

Nielsen

Larsen

et al. 2011

Macromolecular Bioscience

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Nanoassemblies formed by host/guest interactions between two polymers in aqueous media are studied. Two types of polymers with the same dextran backbone are modified with adamantyl or βCD groups. The sizes of the spontaneously formed nanoassemblies depend on the βCD:Ada ratio and on the total concentration and composition of the mixtures. The results can be rationalized by assuming a core/shell structure of the nanoassemblies, the core resulting from associative phase separation of the two polymers and being stabilized by an external shell made of Ada-grafted dextran and containing ions adsorbed from the solution. Hydrophobic compounds such as benzophenone can be incorporated efficiently without inducing changes in properties of the nanoassemblies.

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“…The formation mechanism and the structure of these nanoassemblies have been analyzed using surface tension measurements. A native β-cyclodextrin did not change the surface tension of modified dextran solution, however the addition of polymer β-cyclodextrin increased the surface tension indicating desorption of the modified dextran from the interface (13).…”

Section: Cyclodextrin-drug Complexationmentioning

confidence: 86%

Impact of Surface Tension in Pharmaceutical Sciences

2009

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-Surface chemistry has a large influence in many industries. In the life sciences, surface area is gaining importance in the characterization of materials during their development, formulation and manufacturing. The chemical activity, adsorption, dissolution, and bioavailability of a drug may depend on the surface of the molecule. In order to meet manufacturing challenges and develop new and better performing products with improved qualities, knowledge of surface tension is of utmost importance. An attempt has been made in this paper to review the application of interfacial tension in the key domains of pharmaceutical applications.

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Spontaneous association of hydrophobized dextran and poly-β-cyclodextrin into nanoassemblies.

Cited by 86 publications

References 51 publications

Methods for the Preparation and Manufacture of Polymeric Nanoparticles

Methods for the Preparation and Manufacture of Polymeric Nanoparticles

Size‐Controlled Nanoassemblies Based on Cyclodextrin‐Modified Dextrans

Impact of Surface Tension in Pharmaceutical Sciences

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