This article considers the results of research conducted to define the impact of information technology (IT) on the development of regional transport systems (TS) within the subjects of the Russian Federation. The purpose of this paper is to investigate the impact of digitalization on transport systems and to assess its economic consequences. Methods of analytical modelling, ranging and spatial differentiation are used. The differentiated recommendations are offered for cities, agglomerations and regions for assessing the economic consequences of transport digitalization.